Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.1.108 (TAT)
 2,389 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The fragile site, FRA16B, at 16q22.100 and four different translocations with breakpoints at 16q22.102, 16q22.105, 16q22.108, and 16q22.3 were used to locate and order DNA probes. This was achieved by Southern analysis of a somatic cell hybrid panel containing portions of chromosome 16 and by in situ hybridization. The anonymous DNA fragments D16S6, D16S10, and D16S11 were proximal to FRA16B and located at 16q13----q22.100. D16S4 and LCAT were located at 16q22.100----q22.102. TAT and HP were located at 16q22.105----q22.108. CTRB was located distal to 16q22.105 and therefore is in the distal half of 16q22. The order of markers in this region was determined as centromere-D16S6, D16S11, D16S10, MT-FRA16B-D16S4, LCAT-HP,TAT,CTRB-APRT- telomere. Linkage studies to determine map distances between the closest markers flanking the fragile site are now in progress.
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PMID:Fine mapping of gene probes and anonymous DNA fragments to the long arm of chromosome 16. 290 Aug 8

Pregnant rats were fed six different diets from the first to the 15th, 17th or 19th day of pregnancy. Diets 1 to 5 contained the same amount of nitrogen (10% casein and unsupplemented or supplemented wheat or Bengalgram diets). Diet 6 contained 20% casein. Total placental protein, RNA, free alpha amino N contents and the activities of the enzymes arginase (EC 3.5.3.1), tyrosine amino transferase (TAT, EC 2.6.1.5) and lactate dehydrogenase (LDH, EC 1.1.1.27) were estimated. The fetal weight and placental weight, total placental protein, RNA and free alpha amino N and the activities of the enzymes increased with the gestational age, but the DNA content became constant after day 17 of gestation. The placental weight, protein, free alpha amino N and RNA contents were significantly reduced on wheat and Bengalgram diets as compared to 10% casein (control) diet. The low activities of arginase, TAT and LDH on these diets indicated impaired protein synthesis, as a result of reduction in the amino acid pool size. The fortification of wheat with lysine and Bengalgram with cystine, methionine and tryptophan showed significant improvement in the fetal weight and placental parameters. The values on the 20% casein diet were significantly higher than those observed on the 10% casein diet.
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PMID:Effect of dietary protein composition on placental protein, nucleic acid, free alpha amino N and enzymes in rats. 610 16