Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.108 (
TAT
)
2,389
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons in which glutamatergic excitotoxicity may participate. A recently characterized downstream effector of glutamatergic excitotoxicity is the activation of the lipid transcription factor
sterol regulatory element binding protein-1
(
SREBP1
). Here we report that in spinal cord tissues of transgenic mouse model, G93A, as well as post-mortem spinal cord specimens of human familial and sporadic ALS, significant activation of
SREBP1
following drastic degradation of ER membrane resident protein Insig-1. A
TAT
-fused short peptide (Indip) to prevent Insig-1 degradation and subsequent
SREBP1
activation significantly protected cultured spinal cord neurons against glutamate-induced excitotoxicity. Indip or other
SREBP1
-pathway modulating compounds may prove beneficial in ALS.
...
PMID:Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide. 2187 72
