Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.108 (
TAT
)
2,389
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Heat shock protein 40
(
Hsp40
) functions as a co-chaperone of mammalian Heat shock protein 70 (Hsp70) and facilitates the ATPase activity of Hsp70, and also promotes the cellular protein folding and renaturation of misfolded proteins. In an effort to assess the effects of
Hsp40
, we generated
TAT
-fused
Hsp40
(TAT-Hsp40). The cells were transduced with
TAT
-
Hsp40
and exposed to H(2)O(2). We demonstrated that the
TAT
-
Hsp40
-transduced cells were more resistant to cellular cytotoxicity and cell death. In particular, the degradation of Hsp70 was significantly reduced in
TAT
-
Hsp40
-containing cells as a consequence of reduced ubiquitin-proteasome activity after oxidative injury. These data support the notion that
Hsp40
may confer resistance to oxidative stress via the prevention of proteasome activity.
...
PMID:TAT-Hsp40 inhibits oxidative stress-mediated cytotoxicity via the inhibition of Hsp70 ubiquitination. 1825 97
