Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.1.108 (TAT)
 2,389 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

20 boys aged 13 to 16 yr. and in classrooms for educationally handicapped students were studied by the TAT for adaptive functioning. Scored for pAggression, pDominance, nAggression, nAchievement, and nAutonomy, responses indicated that interactions between these disturbed adolescents and their environment were most likely to involve aggression and dominance and least apt to deal with achievement. Although IQs for all boys were average or above (M: 106), typical responses to the pictures were descriptive rather than development of a complete story. Difficulty in the expression of prediction and interpretation of personal experience was indicated.
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PMID:Perceptions of emotionally disturbed male adolescents on the Thematic Apperception Test. 117 76

The authors mark the following peculiarities of the fixated set in schizophrenia: inertness (in a continuous course); a lability (in acute manifestations of psychoses and in a recurrent course); a variability (in cases of child and adolescent schizophrenia). In terminal cases and in cases of apathic-aboulic syndrome the excitibility level is considerably lowered. The results of a study with the aid of TAT (Murray's Thematic Apperception Test and Rorschach's tests) also depend upon the age of the patients, the form and type of development and the stage of the disease.
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PMID:[Uniqueness of certain structural personality prerequisites in schizophrenia]. 117 98

Analysis of studies of primary process thinking as manifested in Rorschach and TAT production of young children (ages 6 to 10) indicate that children show approximately the same amount of primary process production as do young adults (48% vs 54%). However, this primary process does not appear to be clearly related to the child's creative, scholastic, or perceptual-motor development as measured by appropriate tests. High levels of primary process appear to be significantly related only to the negative qualities of the personality, that is, to high levels of tension, anxiety, and poor control of aggression. It is possible that young children have not yet learned to use it in the service of the ego, although they do not seem to be encumbered by its presence.
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PMID:Regression in the service of the ego in young children. 119 93

Breddin thrombagglutination test is followed up in patients with hypercoagulation states--atherosclerosis, atherosclerotic myocardiodysthrophia, angina pectoris gravis and acute myocardial infarction and hypocoagulation states--esential and symptomatic thrombopenia. TAT is positive in 88% of the patients with atherosclerosis and in patients with angina pectoris gravis and myocardial infarction TAT is Vth stage in 100%. TAT is zero stage in 91% in patients with thrombopenia and only in 9%-I stage. The term "zero stage" is introduced.
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PMID:[Thrombagglutination test (TAT) in hyper- and hypocoagulation]. 122 97

Two major developmentally regulated isoforms of the Drosophila chorion transcription factor CF2 differ by an extra zinc finger within the DNA binding domain. The preferred DNA binding sites were determined and are distinguished by an internal duplication of TAT in the site recognized by the isoform with the extra finger. The results are consistent with modular interactions between zinc fingers and trinucleotides and also suggest rules for recognition of AT-rich DNA sites by zinc finger proteins. The results show how modular finger interactions with trinucleotides can be used, in conjunction with alternative splicing, to alter the binding specificity and increase the spectrum of sites recognized by a DNA binding domain. Thus, CF2 may potentially regulate distinct sets of target genes during development.
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PMID:Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain. 129 May 24

We have developed a sensitive assay for leptospira, using the polymerase chain reaction (PCR). On the basis of the published nucleotides sequence of 23S rRNA gene from Leptospira interrogans serovar canicola strain Moulton, primers were chosen to produce an amplified fragment of 123 bp. Primer A: 5'GAT CTA ATT CGC TGT AGC AGG3' and primer B: 5'ACT TTC ACC CTC TAT GGT CGG3' Eight different svs. of Leptospira interrogans could all be detected by PCR, but the DNAs from L. biflexa. Leptonema bacteria, virus and human could not produce the specific amplified fragment. The assay detected approximately 10 fg of purified leptospiral DNA and 1 microliter serum of experimental animal. Positive results were obtained from simulated positive samples containing a single organism leptospiral DNA. The diagnostic test (proved by "gold standards": Clinical diagnosis; blood culture and MAT) showed that the sensitivity was 92.00%; the specificity 94.35%; the accuracy 92.54%; the positive predictive value 98.17%; the negative predictive value 78.13%; the positive likelihood ratio 16.25; and the negative likelihood ratio 0.0848. The diagnosis of early leptospirosis by using PCR may become a significant addition to diagnostic means.
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PMID:[Detection of leptospiral DNA in the serum of 175 patients with early leptospirosis by polymerase chain reaction]. 129 12

Coagulation activation frequently occurs in cancer patients, resulting in thromboembolic complications and/or intravascular coagulation activation. The mechanisms leading to these alterations still are poorly understood. One explanation for the coagulation activation in malignant diseases is the presence of a direct factor X-activating cancer procoagulant. Coagulation activation in lung cancer patients develops at earlier stages than factor X activation; we demonstrated increased factor IXiAT complexes in addition to elevated TAT complexes. The increases of factor IXiAT complexes were not dependent upon the stage of the disease. In contrast, TAT complexes were higher in patients suffering from advanced pulmonary non-small cell carcinoma than in patients with limited disease. In conclusion, coagulation activation in pulmonary cancer patients occurs at earlier steps in the coagulation cascade than factor X activation. While this activation is not dependent upon the stage of the disease, the observation that TAT complexes showed higher elevations in patients with advanced than in those with limited pulmonary non-small cell carcinoma could be an indication of a cancer procoagulant that directly activates factor X.
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PMID:Factor IXi-antithrombin (IXiAT) and thrombin-antithrombin (TAT) complexes in lung cancer patients. 131 Aug 78

Visna virus is a pathogenic lentivirus of sheep that is distantly related to the primate lentiviruses, including the human immunodeficiency virus type 1 (HIV-1). Replication of HIV-1 in cell culture requires the expression of a virus-encoded protein, Tat, which is a potent trans-activator of viral gene expression. Visna virus encodes an analogous Tat protein that greatly increases gene expression directed by the visna viral LTR. This report uses a stable vero cell line that constitutively expresses visna virus Tat to investigate the molecular mechanism of action of Tat on viral gene expression. Transient expression assays, using the visna virus LTR to drive transcription of the bacterial gene for chloramphenicol acetyltransferase (CAT), demonstrate that Tat trans-activates gene expression by increasing steady-state mRNA levels. The increase in steady-state mRNA levels is sufficient to account for the increase in protein observed and is due, in part, to an increase in the rate of transcription initiation. Tat mediates the accumulation of mRNA through AP-4 and AP-1 binding sites located in the U3 region of the LTR. Deletion of the upstream AP-1 and AP-4 binding sites results in a residual low level of trans-activation by Tat. Further experiments, using LTRs with R-U5 sequences deleted to +10, demonstrate AP-1 and AP-4 mediated responses to TAT at the RNA level, but no increase was observed in CAT protein.
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PMID:Molecular mechanisms of visna virus Tat: identification of the targets for transcriptional activation and evidence for a post-transcriptional effect. 131 69

In seven patients who had to be dialysed between four and 13 times due to acute renal failure, low molecular weight heparin (LMWH) Fragmin was used for anticoagulation. According to dose-finding studies, 80-90 U kg-1 body weight of LMWH as a single bolus were administered initially, producing dose-related levels of 0.3-1.5 anti-factor Xa U ml-1 in plasma. Apart from the anti-Xa activity in the plasma, the thrombin anti-thrombin III complex (TAT complex) and a fibrin degradation product (D-dimer) were measured as parameters of a coagulation activation. A sufficient anti-coagulation during dialysis was supposed to exist at a normal range (5.0 micrograms l-1 or below) of TAT complex. Pathological TAT concentrations at the end of dialysis indicated the requirement of an increased dose for the next dialysis. These concentrations reflected a need for more heparin if, for example, inflammation, indicated by increasing C-reactive protein levels (CRP), occurred. The increase of TAT complex and D-dimer during dialysis showed a good agreement (p less than 0.001). Due to a single bolus application before dialysis, one measurement of TAT at the end of the dialysis was sufficient. The determination of the TAT complex concentration enabled a heparinization better adapted to the clinical situation of intensive-care patients undergoing acute dialyses, so that the coagulation system was not additionally activated by the extracorporeal circulation.
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PMID:The control of anti-coagulation in acute dialyses with sensitive laboratory parameters. 133 80

The authors have designed two variants of the "verbal projective test" (VPT) in view of the lack of a projective method genetically similar to the TAT, according to which, however, emotionally saturated, indefinite phrases as regards the content could be used as stimulus material. Theoretically, it could be of special interest in psychopathological cases associated with thinking disorders, as well as "compensate" for the tendency toward TAT aging. Using VPT 19 probands with little progressive neurosis-like schizophrenia and 19 probands with lingering neuroses were examined. The findings were estimated polyfactorially in terms of the main assumptions of TAT interpretation but with a mandatory inclusion into the analysis of the lexico-grammatical evaluation of the stories. It has been established in the course of the work that the leading differences in the delimiting of neuroses and little progressive neurosis-like schizophrenia are emotional disorders (their character and intensity) diagnosed, equally to certain thinking disorders, with the aid of the new method. It has been also shown that the new VPT is fit for analysis of the speech of the persons suffering from various mental disorders.
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PMID:[A new verbal projective method for studying personality]. 133 70


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