Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.108 (
TAT
)
2,389
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A novel carrier system that originates from membrane shuttling proteins such as the Drosophila
homeobox protein
Antennapedia, the HIV-1 transcriptional factor
TAT
and VP22 from HSV-1 has advantages for targeted delivery compared with standard translocation techniques. This transport system is mediated by so-called cell-penetrating peptides, which consist of short peptide sequences that rapidly translocate large molecules into the cell interior in a seemingly energy- and receptor-independent manner. Cell-penetrating peptides have low toxicity and a high yield of delivery and in the future might become a widely used tool in the field of gene regulation.
...
PMID:The use of cell-penetrating peptides as a tool for gene regulation. 1547 18
