Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.108 (
TAT
)
2,389
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Isoproterenol, phenylephrine, and salbutamol (all 100 microM) induced the activity of tyrosine aminotransferase (
TAT
; EC 2.6.1.5) by 109%, 72%, and 141%, respectively, in organ culture of fetal human liver.
Propranolol
(100 microM) inhibited the effects of isoproterenol and phenylephrine. In organ culture of fetal rat liver, the induction of
TAT
activity by phenylephrine (100 microM) was not significantly affected by phentolamine (100 microM), whereas it was abolished by a combination of phentolamine and propranolol (both 100 microM). Isoproterenol and salbutamol caused significant increases in
TAT
activity, which were not affected by 100 microM atenolol but were completely inhibited by propranolol (100 microM). The results show that the fetal human liver has developed responsiveness to adrenergic stimuli at the 12th week of gestation. The adrenergic induction of
TAT
in fetal human liver is mediated solely by beta-adrenergic mechanisms. In the fetal rat liver, the adrenergic induction of
TAT
is mediated by beta 2-adrenergic receptors.
...
PMID:beta-Adrenergic induction of tyrosine aminotransferase organ culture of fetal rat and fetal human liver. 612 30
