Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.108 (
TAT
)
2,389
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Incorporation of a guanidine functional group into the
PNA
backbone facilitates cellular uptake of
PNA
into mammalian cells with efficiency comparable to that of the
TAT
transduction domain. The modified
PNA
recognizes and binds to the complementary DNA strand in accordance with Watson-Crick recognition rules. However, unlike polypyrimidine
PNA
which binds to DNA in 2:1 stoichiometry, the modified
PNA
binds to complementary DNA in a 1:1 ratio to form a highly stable duplex.
...
PMID:Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA). 1278 35
