Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.108 (
TAT
)
2,389
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this work we analysed the characteristics of the cell-permeable peptide
TAT
-PTD fused to
cystatin B
(
CSTB
) to evaluate its potential for protein therapy of Unverricht-Lundborg (UL) epilepsy.
TAT
-PTD-
CSTB
does not penetrate the cells despite initial evidence of time and concentration-dependent transduction. Therefore, it cannot be used as a form of replacement of the intracytoplasmic protein missing in UL. Importantly, we discuss precautions to avoid false-positive results when working with
TAT
-PTD for protein therapy of neurological diseases.
...
PMID:Protein therapy for Unverricht-Lundborg disease using cystatin B transduction by TAT-PTD. Is it that simple? 1693 Sep 46
