Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.1.108 (TAT)
 2,389 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Response styles and defensive patterns of 30 polydrug abusers, 30 sedative-hypnotic abusers, and 30 hospitalized medical control subjects were assessed. These subjects were drug-free and matched for sex, WAIS IQ, and socioeconomic status. The Rorschach was administered to all subjects. A frustration-producing task (insolvable anagrams) was administered to half of the subjects in each group. Solvable anagrams were administered to the remaining subjects. All subjects were then asked to select one of two stories for each of eight TAT cards and complete a Profile of Mood States Questionnaire. The Rorschach data indicate that polydrug abusers are less well organized, less able to delay gratification, and more restless and distractible when compared to the sedative-hypnotic and control groups. The behavioral data lend support to the pharmacodynamic theory of drug abuse in that each drug abuser group responded to the frustration produced by the inability to solve anagrams in a way consistent with the effects of the abused drugs. Implications of these data for treatment planning are discussed.
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PMID:Preferential drug abuse: defenses and behavioral correlates. 741 78

The magnitude of the problems of drug abuse and Neuro-AIDS warrants the development of novel approaches for testing hypotheses in diagnosis and treatment ranging from cell culture models to developing databases. In this study, cultured neurons were treated with/without HIV-TAT, ENV, or cocaine in a 2x2x2 expression study design. RNA was purified, labeled, and expression data were produced and analyzed using ANOVA. Thus, we identified 35 genes that were significantly expressed across treatment conditions. A diagram is presented showing examples of molecular relationships involving a significantly expressed gene in the current study (SOX2). Also, we use this information to discuss examples of gene expression interactions as a means to portray significance and complexity of gene expression studies in Drug Abuse and Neuro-AIDS. Furthermore, we discuss here that critical interactions remain undetected, which may be unravelled by developing robust database systems containing large datasets and gleaned information from collaborating scientists . Hence, we are developing a public domain database we named The Agora database , that will served as a shared infrastructure to query, deposit, and review information related to drug abuse and dementias including Neuro-AIDS. A workflow of this database is also outlined in this paper.
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PMID:Bioinformatics models in drug abuse and Neuro-AIDS: Using and developing databases. 1759 62