Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.1.107 (DAT)
 1,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

RBCs with a positive DAT due to IgG coating require the use of directly agglutinating reagents or treatment with chemicals to remove sufficient IgG to permit typing of the RBCs with antisera that require use of the IAT. In this study we demonstrate that murine IgG MoAbs to human RBC antigens can be used as an alternative if the anti-mouse IgG is neutralized or affinity purified to prevent cross-reaction with cell-bound IgG. We performed DATs on RBC samples coated with IgG in vivo and in vitro, comparing two anti-human IgG reagents (Organon Teknika, Durham, NC, and Ortho-Clinical Diagnostics, Raritan, NJ) with two affinity-purified anti-mouse IgG reagents (The Binding Site, San Diego, CA, and Sigma, St. Louis, MO), and one non-purified anti-mouse IgG reagent. The affinity-purified anti-mouse IgG reagents were nonreactive with the four in vitro sensitized RBC samples and were nonreactive with 8 of 11 in vivo sensitized RBC samples. Non-purified antimouse IgG and both anti-human IgG reagents reacted with every sample. Use of murine MoAbs to antigen type RBCs coated with human IgG is reliable only when the anti-mouse IgG reagents have been affinity purified or neutralized to prevent cross-reactivity. Our results also show the importance of including a saline/RBC control as well as an anti-mouse IgG/RBC control. Murine MoAbs are valuable reagents and we have applied them successfully in typing patients' RBCs that have a positive DAT.
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PMID:Murine monoclonal antibodies can be used to type RBCs with a positive DAT. 1537 85

The University of Texas Health Science Center at San Antonio (UTHSCSA) Dental School recruits a student body from a wide number of undergraduate institutions, primarily in Texas. One method supporting this effort is the Dental Early Acceptance Program (DEAP). This program is unique in that it grants conditional acceptance to dental school during a student's first year of undergraduate education and admission upon completion of three years of college coursework as directed by the student's undergraduate academic advisor. The purpose of this study was to assess and compare the academic performance of DEAP students to students accepted through the standard competitive admissions process. The academic records of all students matriculating into our dental school between 1993 and 1996 were examined. National Board Dental Examination Parts I and II scores, the cumulative dental school and college GPAs, DAT scores, and demographic data were recorded. The data were analyzed descriptively and statistically. Graduation rates were 92 percent for DEAP students and 94 percent for standard admissions students. Comparison of college cumulative GPA between the two groups showed no statistically significant difference. A significant difference was found between the groups in their dental school cumulative GPA. In a comparison of National Board Examination scores, DEAP students had a significantly lower NBDE Part I mean score (82.9) than standard admissions students (85.8). DEAP students also showed significantly lower NBDE Part II scores (80.4) than standard admissions students (82.4).
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PMID:Outcome assessment of the Dental Early Acceptance Program. 1627 86

The University of California, San Francisco School of Dentistry established the Dental Postbaccalaureate Program in 1998 to provide reapplication assistance to students from economically and/or educationally disadvantaged backgrounds who were previously denied admission to dental school. The goals were to increase diversity in the dental school student population and improve access to dental services for underserved populations. This article assesses the program's short-, mid-, and long-term outcomes and is the first to examine long-term practice patterns after a dental postbaccalaureate program. Data collected on all participant (n=94) demographics, pre/post-program DAT scores, and post-program dental school admission results were used to assess short- and mid-term outcomes. Long-term outcomes and practice patterns were assessed using results of a census survey administered between 2009 and 2011 to the participants who had completed dental school and been in practice for at least two years (n=57). The survey had a response rate of 93 percent (n=53). Descriptive statistical techniques were used to examine the responses and to compare them to U.S. Census Bureau data and nationally available practice data for new dental graduates. Program participants' DAT scores improved by an average of two points, and 98 percent were accepted to dental school. All survey respondents were practicing dentistry, and 81 percent reported serving underserved populations. These participants treat more Medicaid recipients than do most dentists, and their patient population is more diverse than the general population. The outcomes demonstrate that the program's graduates are increasing diversity in the dental student population and that their practices are providing access to care for underserved populations.
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PMID:Long-term outcomes of a dental postbaccalaureate program: increasing dental student diversity and oral health care access. 2365 97