Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.107 (
DAT
)
1,471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Glucose metabolism in the brain is an important process that influences many normal cellular processes, from neurotransmitter synthesis to ATP production. While cortisol and insulin have opposing effects on glucose metabolism, desensitization of the neuronal
insulin receptor
results in metabolic abnormalities. In the normal aging brain, glucose/energy metabolism is decreased slightly. In the majority of cases. Alzheimer's disease is sporadic and has a late onset. Therefore, age-related variations in cellular metabolism following the principle of self-organized criticality may come into focus with respect to the etiopathogenesis of this neurodegenerative disorder. As a possible primary abnormal event in late-onset sporadic
DAT
, a prolonged desensitization of the neuronal
insulin receptor
is assumed to be responsible for cascade-like abnormalities in oxidative energy metabolism and related metabolism with impacts on amyloid formation.
...
PMID:Models of Alzheimer's disease: cellular and molecular aspects. 926 10
