Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.1.107 (DAT)
 1,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the study was to investigate the biodegradability of guanyl urea (GU) and the behavior of other transformation products (TPs) of Metformin (MF). Most biodegradation studies of MF with activated sludge of waste water treatment plants (WWTPs) showed GU as the only bacterial dead-end metabolite without further degradation. In this study, batch experiments with activated sludge revealed biodegradability of GU. GU degradation was much faster under anaerobic than under aerobic conditions. Degradation kinetics for MF was much slower under anaerobic conditions. Adsorptive removal of up to 20% was an additional elimination process of MF and GU. The batch experiments were conducted with sludge of 2 WWTPs, WWTP 1 showed decreasing concentrations of GU from influent to effluent and the other increasing concentrations. This indicates a different adaption of the sludge to GU and may explain the better GU degradation capability of the sludge from WWTP 1. Furthermore, the biodegradation potential of MF was confirmed and in addition, occurrence of the TPs methylbiguanide (MBG), 2-amino-4-methylamino-1,3,5-triazine (2,4-AMT) and the secondary TP 2,4-diamino-1,3,5-triazine (2,4-DAT) was observed in batch experiments with activated sludge of WWTP 1. After fast formation, degradation in turn was slower, especially for 2,4-AMT. In general, TPs played a minor role in MF and GU degradation.
 ...
PMID:Aerobic and anaerobic formation and biodegradation of guanyl urea and other transformation products of metformin. 3043 76

Metformin (MET) is the most common drug used to treat type 2 diabetes, but also it is used as an anticancer agent and as a treatment for polycystic ovary syndrome. This drug is not metabolized in the human body, and may enter into the environment through different pathways. In wastewater treatments plants (WWTPs), this contaminant is mainly transformed to guanylurea (GUA). However, three further transformation products (TPs): (a) 2,4- diamino-1,3,5-triazine, 4-DAT; (b) 2-amino-4-methylamino-1,3,5-triazine, 2,4-AMT; and (c) methylbiguanide, MBG; have also been associated with its metabolism. MET, GUA and MBG have been found in WWTPs influents, effluents and surface waters. Furthermore, MET and GUA bioaccumulate in edible plants species, fish and mussels potentially contaminating the human food web. MET is also a potential endocrine disruptor in fish. Phytoremediation, adsorption and biodegradation have shown a high removal efficiency of MET, in laboratory. Nonetheless, these removal methods had less efficiency when tried in WWTPs. Therefore, MET and its TPs are a threat to the human being as well as to our environment. This review comprehensively discuss the (1) pathways of MET to the environment and its life-cycle, (2) occurrence of MET and its transformation products (3) removal, (4) toxic effects and (5) future trends and perspectives of possible methods of elimination in water in order to provide potential options for managing these contaminants.
 ...
PMID:Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives. 3172 46