Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.1.107 (DAT)
 1,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The risk for Alzheimer's disease (DAT) increases with increasing genetic relationship to an affected person. The empirical risk is highest for relatives of persons with relatively youthful onset. However, the incidence of cases with late onset may be underestimated because of a ceiling effect imposed by the human life span. Differences in age at onset between index cases (probands) and their affected relatives provide evidence that relative severity of illness is an important parameter of illness to note and analyze. These findings have important implications for genetic counseling. Other evidence from family studies provides leads to molecular genetics. Finally, studies of identical twins, though limited to a few pairs, strongly imply that, in principle, the development of Alzheimer's disease can be prevented.
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PMID:Family studies in Alzheimer's disease. 269 Jan

This study attempted to determine if students with certain personality preferences outperform others over the course of the initial dental school year. The Myers-Briggs Type Indicator (MBTI) was used to assess the relationship between personality preferences and academic performance. One hundred and ninety-nine dental students in four successive first-year classes, 1983-86, participated. Pearson correlation coefficients were used to relate academic performance (first-semester, second-semester, and first-year GPAs) to personality preferences (EI, SN, TF, JP) and academic predictors (entering GPA and DAT scores). For personality preferences, all correlation coefficients were low and nonsignificant. In comparison, entering GPA and DAT (academic) scores were significantly correlated with first-semester, second-semester, and first-year GPAs. DAT (perceptual ability) scores showed a significant correlation with first-semester GPAs only.
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PMID:Personality variables as predictors of performance for first-year dental students. 270 80

A 40-year-old man who developed acute myelomonoblastic leukemia (M4) after 7 years of treatment for multiple myeloma with the alkylating agent melphalan and steroids is presented. Leukemia was treated with courses of adriblastin, cytosine arabinoside, and thioguanin (DAT protocol), with a 8 months' survival.
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PMID:Acute myelomonoblastic leukemia in a patient with multiple myeloma. 271 63

The grammatical semantic abilities of 18 Alzheimer patients were investigated using picture description tasks and compared to those of a group of institutionalized, nonneurologically impaired control subjects matched for age, sex, and educational level. During picture description, Alzheimer patients showed that they were able to provide as much information about the target picture as control subjects, but were less concise in their verbal representation of the information. The lack of conciseness was reflected in the DAT patients requiring more time and more syllables to communicate a similar quantity of information than the control subjects. The appropriateness of using a picture description task which involves a perceptual step-by-step account of unrelated events to assess sentential semantics and the conveying of information at a conceptual level is discussed.
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PMID:Semantic abilities in dementia of the Alzheimer type. II. Grammatical semantics. 272 Mar 69

Hypertensive heart disease has an important place among the cardiovascular diseases. There are evidences that the behavior of arterial tension (AT) in children can predict the possible appearance of arterial hypertension (AH) in the adult. The foreign percentile curves, when applied to our population, show either under or overestimation of the cases. This is the reason for the need of having our own percentile tables. In this study we found different mean values for systolic and diastolic arterial tension (SAT and DAT) between the sexes, being these higher for the males, but these differences had no statistical significance. We present percentile tables for AT per sex against age, weight, height and corpulence index (CI). According to WHO, when a child has three measurement over the 95 percentile he should be considered AH. The tables for height, weight, and CI should be used only under special circumstances.
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PMID:[Percentile curves of arterial tension in school children from Mexico City]. 275 38

In view of national concerns about student aptitude and overcrowded curricula, the effectiveness of review courses must be evaluated objectively. The present study is a statistical analysis of the impact of a review course on National Board Examination (NBE) Part I performance at the University of Detroit. The performance of dental students who had taken the course between 1985 and 1987 (N = 175) was compared to that of the prior three classes (N = 212). Analysis of covariance (ANCOVA) was used to adjust and compare mean scores on the NBE, using entering GPA and DAT scores, both measures of aptitude, as covariates. Only two of the five NBE scores demonstrated significant improvement. While aptitude contributed as much as 23 percent to NBE performance, the contribution of the review course was limited to 1.5 percent. The review course was most effective in areas that (1) were covered during the greatest number of terms, (2) were presented most recently, or (3) had the least number of topics on the NBE. This strategy for evaluating course effectiveness permits a dental school to easily assess the value of an NBE review course, as well as identify strengths and weaknesses in the curriculum.
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PMID:Effectiveness of a national board review course for dental students. 275 79

We compared the findings of computed tomography (CT), magnetic resonance (MR), and positron emission tomography (PET) scans of glucose metabolism in 30 patients with clinically diagnosed Alzheimer's Disease (DAT) to those noted in 25 age-matched normal controls. Mean ratings of cortical and ventricular atrophy on CT and of metabolic abnormality on PET were significantly different (p less than 0.001 and p less than 0.0001, respectively) between two subject groups, however, there was a considerable overlap in reading of cortical atrophy. CT hypodensities were present in 17% of DAT patients and 12% of controls. MR revealed numerous additional periventricular and deep white matter signal changes. Neither hypodensities nor hyperintensities were correlated with PET abnormalities. Although, not infrequently, hypometabolic areas on PET scans corresponded to atrophic regions on anatomic images, they also occurred without such changes. Interestingly, cortical high signal intensity seen on MRI was frequently observed to be associated with areas of hypometabolism. Our results suggest that PET may be the most sensitive modality for detecting cortical involvement in DAT.
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PMID:Comparison of CT, MR, and PET in Alzheimer's dementia and normal aging. 279

Twelve patients with acute lymphoblastic leukemia (ALL) were treated with aclacinomycin A (60 mg/m2/day for five days) and VP-16-213 (100 mg/m2/day). All were heavily pretreated and had relapsed or were refractory to primary or subsequent treatment. Eight patients were refractory to reinduction therapy given for first, second, third or fourth relapse. One patient was treated in third relapse; one in second relapse (after a short second remission) and two in first relapse-one with the Ph1 chromosome, after a four-month remission, and one patient who relapsed while receiving consolidation therapy. Four patients (33 per cent) responded, three entered complete remission (25 per cent), and one a partial remission (8 per cent). Two of the patients treated for refractoriness to reinduction therapy went into complete remission. Side effects from this treatment were similar to the conventional DAT regimen (daunorubicin, cytosine arabinoside, thioguanine), although the gastrointestinal toxicity and mucositis appeared to be more severe in this study population. One of the patients had severe ventricular arrhythmias which contributed to her death. The complete remission rate (25 per cent) in this group of very heavily pretreated ALL patients warrants further studies to evaluate these preliminary findings.
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PMID:Refractory acute lymphocytic leukemia: response to aclacinomycin A and VP-16-213. 280 78

One patient with acute nonlymphocytic leukemia (ANLL) in remission was given intensive chemotherapy (DAT regimen) as late intensification treatment. Seven leukaphereses were performed during the period of marrow recovery following aplasia induced by the DAT regimen. High numbers of nucleated cells (7.8 X 10(8)/kg) and granulocyte-macrophage precursors (9.5 X 10(4)/kg) were collected and then cryopreserved and stored in liquid nitrogen. When he relapsed, the patient was treated with etoposide (600 mg/m2), cyclophosphamide (120 mg/kg), and total body irradiation (1000 rad), followed by the transfusion of thawed autologous leukocytes. The time to reach 0.5 X 10(9) granulocytes/liter and 50 X 10(9) platelets/liter was 16 and 35 days, respectively. This observation demonstrates that circulating hemopoietic stem cells are capable of complete hemopoietic reconstitution after marrow-ablative therapy with supralethal doses of chemoradiotherapy.
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PMID:Successful autologous transplantation with peripheral blood hemopoietic cells in a patient with acute leukemia. 287 Sep 36

Between 1978 and 1983, 1127 patients with de-novo acute myeloid leukaemia (AML) were entered into the Medical Research Council (MRC)'s 8th AML trial. All received the same induction therapy consisting of daunorubicin, cytarabine, and 6-thioguanine--DAT (1 + 5). The 67% who entered complete remission were randomised to consolidation with two or six further courses of DAT. Adults under the age of 55 were randomised for central nervous system (CNS) prophylaxis with intrathecal cytarabine and methotrexate. Finally, those still in remission after 1 year of cytarabine and 6-thioguanine (AT) maintenance were randomised to receive either late intensification with cyclophosphamide, vincristine, cytarabine, and prednisolone (COAP) or continued AT. The median survival for the whole group was 12 months; the median duration of first remission was 15 months, with relapse-free survival at 5 years estimated at 18%. The factors most strongly associated with poor survival were performance status and age at presentation, but even among those over 60 years of age, half went into remission. Six courses of DAT consolidation gave a small advantage over two courses in reducing the number of late relapses but no significant survival advantage. Late intensification showed a marginally significant advantage over continued AT maintenance. The incidence of CNS relapse was low and unaffected by prophylaxis. The second remission rate varied from 10% when the first remission was shorter than 6 months to 61% when it had continued for more than 2 years. 40 patients received histocompatible allogeneic bone-marrow transplants in first remission. There was a high procedure-related death rate, particularly among patients over 30 years of age. Thus, initially at least, the transplanted group had shorter survival than a comparable group of chemotherapy-treated patients. Treatment specifications remained unchanged throughout the trial but those enrolled in the later half of the trial had a better (p = 0.003) survival.
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PMID:Principal results of the Medical Research Council's 8th acute myeloid leukaemia trial. 287 30


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