Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.107 (
DAT
)
1,471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A series of N-8-substituted benztropinamines was synthesized and evaluated for binding at the dopamine (
DAT
), serotonin (SERT), norepinephrine (NET) transporters, and muscarinic M1 receptors. In general, the isosteric replacement of the
C-3
benzhydrol ether of benztropine by a benzhydryl amino group was well tolerated at the
DAT
. However, for certain N-8 substituted derivatives, selectivity over muscarinic M1 receptor affinity was reduced.
...
PMID:N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. 1621 21
