Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.107 (
DAT
)
1,471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have treated 19 B-chronic lymphocytic leukaemia (B-CLL) patients with
CDA
(Leustat, Janssen-Cilag). Four patients developed severe autoimmune haemolytic anaemia, and 2 of these had severe reticulocytopenia due to red cell aplasia/hypoplasia. Two patients died as a complication of the haemolysis one during the primary episode, with a clinical course suggestive of transfusion associated graft-versus-host disease (taGVHD), and one following a relapse of haemolysis. The onset of haemolysis occurs within 4 cycles of
CDA
therapy and is temporally related to the T-lymphocyte nadir induced by
CDA
. The presence of a positive
DAT
prior to therapy in 3 of 4 patients developing haemolysis suggests that the
CDA
induced T-lymphocytopenia may exacerbate the tendency of certain CLL patients to autoimmune haemolysis.
...
PMID:Autoimmune haemolysis in patients with B-CLL treated with chlorodeoxyadenosine (CDA). 968 36
