Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.107 (
DAT
)
1,471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In
Caenorhabditis elegans
, SHN-1 is the homologue of
SHANK
, a scaffolding protein. In this study, we determined the molecular basis for SHN-1/
SHANK
in the regulation of innate immune response to fungal infection. Mutation of
shn-1
increased the susceptibility to
Candida albicans
infection and suppressed the innate immune response. After
C. albicans
infection for 6, 12, or 24 h, both transcriptional expression of
shn-1
and SHN-1::GFP expression were increased, implying that the activated SHN-1 may mediate a protection mechanism for
C. elegans
against the adverse effects from fungal infection. SHN-1 acted in both the neurons and the intestine to regulate the innate immune response to fungal infection. In the neurons, GLR-1, an AMPA ionotropic glutamate receptor, was identified as the downstream target in the regulation of innate immune response to fungal infection. GLR-1 further positively affected the function of SER-7-mediated serotonin signaling and antagonized the function of
DAT
-1-mediated dopamine signaling in the regulation of innate immune response to fungal infection. Our study suggests the novel function of SHN-1/
SHANK
in the regulation of innate immune response to fungal infection. Moreover, our results also denote the crucial role of neurotransmitter signals in mediating the function of SHN-1/
SHANK
in regulating innate immune response to fungal infection.
...
PMID:Regulation of Innate Immune Response to Fungal Infection in
Caenorhabditis elegans
by SHN-1/SHANK. 3295 30
