Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.107 (
DAT
)
1,471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Biochemical and histochemical studies have demonstrated a widespread deficit in the activity of acetylcholinesterase (AChE) in the brains of patients with Alzheimer's disease (
DAT
). Multiple disturbances in several transmitter systems have been found. The most consistent neurochemical changes in
DAT
are reductions in the cholinergic system. The major pharmacological approach today in
DAT
is based on the cholinergic theory assuming that acetylcholine has a major cortical impact on cognitive processes.
Tetrahydroaminoacridine
(
THA
, tacrine) is a centrally active reversible acetylcholinesterase inhibitor. A large number of trials have been performed in patients with
DAT
. This article was to evaluate whether
THA
treatment induced neuropeptide alteration in
DAT
before and after 1 year on oral
THA
treatment.
...
PMID:Tacrine treatment modifies cerebrospinal fluid neuropeptide levels in Alzheimer's disease. 786 82
