Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.107 (
DAT
)
1,471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The physiological functions of neurotransmitter:sodium symporters (NSS) in reuptake of neurotransmitters from the synapse into the presynaptic nerve have been shown to be complemented by their involvement, together with non-plasma membrane neurotransmitter transporters, in the reverse transport of substrate (efflux) in response to psychostimulants. Recent experimental evidence implicates highly anionic phosphatidylinositol 4,5-biphosphate (
PIP
(2)) lipids in such functions of the serotonin (SERT) and dopamine (
DAT
) transporters. Thus, for both SERT and
DAT
, neurotransmitter efflux has been shown to be strongly regulated by the presence of
PIP
(2) lipids in the plasma membrane, and the electrostatic interaction of the N-terminal region of
DAT
with the negatively charged
PIP
(2) lipids. We examine the experimentally established phenotypes in a structural context obtained from computational modeling based on recent crystallographic data. The results are shown to set the stage for a mechanistic understanding of physiological actions of neurotransmitter transporters in the NSS family of membrane proteins. This article is part of a Special Issue entitled: Lipid-protein interactions.
...
PMID:Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. 2584 98
