Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.1.1.74 (
folate-dependent ribothymidyl synthase
)
2
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The two long-known "classical" enzymes of uridyl-5-methylation,
thymidylate synthase
and ribothymidyl synthase, have been joined by two alternative methylation enzymes, flavin-dependent
thymidylate synthase
and
folate-dependent ribothymidyl synthase
. These two newly discovered enzymes have much in common: both contain flavin cofactors, utilize methylenetetrahydrofolate as a source of methyl group, and perform thymidylate synthesis via chemical pathways distinct from those of their classic counterparts. Several severe human pathogens (e.g., typhus, anthrax, tuberculosis, and more) depend on these "alternative" enzymes for reproduction. These and other distinctive properties make the alternative enzymes and their corresponding genes appealing targets for new antibiotics.
...
PMID:Thymidyl biosynthesis enzymes as antibiotic targets. 1721 55
