Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.1.1.69 (
BMT
)
2,655
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In a patient undergoing allogeneic
BMT
for ALL, chronic GVHD (cGVHD) with skin changes developed within 110 days after transplantation. One year post-
BMT
, anti-nuclear antibodies were detected. The patient's serum was used for immunoscreening of a HeLa cDNA library. Ten different overlapping positive clones were found to be partial clones of
mitosin
, a 350-kDa nuclear phosphoprotein which shows a speckled nuclear distribution in S phase and which relocates to the centromere and mitotic apparatus in M phase. Although autoantibodies against centromere protein-F, which is very similar to
mitosin
, have been reported in patients with cancer, this is the first report of autoantibodies against
mitosin
in a patient with cGVHD.
...
PMID:Anti-mitosin antibodies in a patient with chronic graft-versus-host disease after allogeneic bone marrow transplantation. 915 73
