Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.69 (BMT)
 2,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighty-five patients who had undergone BMT for malignant blood disease or aplastic anemia at the Helsinki University Central Hospital, Finland were tested for hepatitis C antibodies (anti-HCV). Eight (9.4%) patients were anti-HCV positive according to a second generation enzyme linked immunosorbent assay (ELISA). Seven (87.5%) of the ELISA positive results could be confirmed by a supplemental test, the second generation recombinant immunoblot assay (RIBA-4). Two patients were constantly seropositive, one patient was seropositive prior to BMT but became antibody negative soon after BMT, and four patients seroconverted after BMT. Six of the seven confirmed anti-HCV positive patients had biochemical evidence of liver damage, but none had fulminant hepatitis or hepatic failure. Liver enzyme abnormalities consistent with a possible non-A, non-B hepatitis were significantly more prevalent among the seropositive than seronegative patients (p < 0.05). The intensive immunosuppression associated with BMT seemed to have little effect on the ability to produce antibodies for hepatitis C virus (HCV). The pattern of antibodies towards different HCV antigens in RIBA-4 was inconsistent, but the present results suggest that antibodies to a core antigen (C22) may, in some cases, be detected earlier than other HCV antibodies during early HCV infection. Moreover, ELISA became positive earlier than RIBA-4 in some patients.
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PMID:Hepatitis C infection in BMT patients. 767 97

We evaluated therapy complications in 19 beta-thalassemia major patients (mean age from 3 years/5 months and 1 years/6 months) who were followed at II Pediatric Department-University of Bari. 3 out of 19 patients underwent allogenic BMT from matched related donor; 2 out of 19 underwent splenectomy. All of them were receiving hypertransfusion therapy and continuous chelation with DFO. In all patients we performed physical examination, laboratory assays, cardiac and endocrinologic function tests, serum HBV-HCV-HIV antibodies, otoscopy and audiometric test, fundus oculi, skeletal x-ray. 1 out of 19 patients, who was under 15, had a slight dilatation of left ventricle and arythmia. All patients were HBsAb positive. 4/19 patients were HCV Ab positive (ELISA test) with an increase in ALT-AST serum levels since at least 6 months. In 3 of them we assessed RIBA test, always positive. 3 of them underwent liver biopsy (1 iron overload 2 chronic active hepatitis). All patients were HIV Ab negative. 4/15 patients revealed low GH levels after Arginina test. 13 pre-pubescent patients had normal results with GNRH test but lower results after FSH test. 1 pubescent patient had gonadotropic hypophyseal deficit. 4 patients had subclinic hypothiroidism. We couldn't find any sequelas in bone-eyes-ears. Hypertransfusion therapy, chelation, profilaxis of infections improved length and quality of life in thalassemic patients. Hypogonadotropic hypogonadism remains a serious sequela and we think it needs to be treated.
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PMID:[Long-term effects of combined therapy in patients with beta-thalassemia major]. 965 19