Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.69 (BMT)
 2,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

While research has documented neuropsychological sequelae following cranial radiation and chemotherapy for childhood cancer, little is known about the effects of the BMT process on the neuropsychological functioning of children. Results from ongoing studies at The University of Iowa indicate that at pre-BMT evaluations, children who have had prior CRT already show signs of declining IQ scores and below average academic achievement. By 4 years post-BMT, there is evidence of declining IQ, achievement, memory, and fine motor skills. Risk factors appear to be younger age at diagnosis and CRT prior to BMT but additional research is needed.
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PMID:Long-term neuropsychological risks in pediatric bone marrow transplant: what do we know? 897 8

Parathyroid function was recently reported to be affected in more than one-third of pediatric BMT patients conditioned without irradiation. Our aim was to describe parathyroid function in children with malignant hematological disease after autologous BMT with and without TBI. PTH, albumin-corrected serum calcium, and serum phosphate were analyzed in 35 children followed for six months to nine yr after BMT. Twelve patients were conditioned with chemotherapy alone, and 23 patients received TBI as well. In the TBI group, 11 patients had previously received additional CRT. We found normal levels of PTH in children post-BMT, with the exception of four patients (11%) who showed transient PTH elevation during the first year of follow-up, There was no difference between those who had received irradiation and those who had not. Serum calcium was unchanged after BMT. An age-corrected quotient of serum phosphate decreased slightly. Renal function which was normal before BMT decreased slightly in both groups after BMT, but was within the normal range. Parathyroid function was found to be normal during the time frame of this study, irrespective of whether irradiation had been given.
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PMID:Normal long-term parathyroid function after autologous bone marrow transplantation in children. 1730 May 2