Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.69 (BMT)
 2,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of a multi-agent regimen on oropharyngeal candidiasis (OPC) prophylaxis in 16 consecutive pediatric bone marrow transplant patients was assessed. The multi-agent regimen consisted of: 1) debriding all mucous membrane surfaces within the oropharyngeal cavity with povidone-iodine 4 times a day, 2) swabbing all mucous membrane surfaces within the oropharyngeal cavity with nystatin 4 times a day, and 3) Ketoconazole given daily by mouth. Multi-agent regimen therapy was initiated on the day marrow ablative therapy began, and was terminated when the patient's absolute neutrophil count recovered to above 500/mm3. Baseline oropharyngeal fungal cultures indicated that 8 out of 16 (50%) of the patients were Candida carriers. Subsequent surveillance cultures indicated that 13 out of 16 (81.3%) of the patients had negative oropharyngeal fungal cultures during the entire period they were on the multi-agent regimen. The remaining three patients had negative oropharyngeal fungal cultures by the end of the experimental period. None of the patients developed Candida esophagitis or sepsis. The above regimen is an effective and non-toxic method to prevent oropharyngeal candidiasis in pediatric BMT patients.
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PMID:Oropharyngeal Candida prophylaxis in pediatric bone marrow transplant patients. 389 1

In our clinic, between May 1988 and December 1994, 117 bone marrow transplants (78 allogenic BMT (alloBMT), 26 autologous BMT (autoBMT), 13 autologous peripheral stem cell transplant (autoPSCT). Eighty-six (73.5%) febrile neutropenic episodes (FNEs) were encountered (64 alloBMTs, 15 autoBMTs, 7 autoPSCTs). There were 28 (32.5%) microbiologically documented infections, 18 (20.9%) clinically documented infections and 40 (46.5%) FUO. Gram-positive microorganisms were the most frequently isolated agents (57.1%) and Staphylococcus spp. were the main pathogens to cause bacteremia (%54.1). Enterobacter spp. were the most common (75%) in urinary tract infections, FNEs were most frequently (82%, 64 78 ) encountered in AlloBMT patients. No significant difference in the number of FNEs was found between autoBMT and autoPSCT groups (P < 0.05). Overall response rate to empirical antibiotherapy was 87.2% (75 86 ) and the success of treatment disclosed no difference in relation to transplant type and definition of infection (P > 0.05). Seven (6%) patients suffered from catheter infections and eight (7%) from Candida esophagitis.
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PMID:Febrile neutropenia in a bone marrow transplantation unit. 1861 93