Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.69 (BMT)
 2,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To study the potentialities of MR tomography in the diagnosis of chromaffin tissue tumors and to elaborate a number of quantitative diagnostic criteria, 26 patients with pheochromocytoma were examined. All the patients were subjected to x-ray computer-aided tomography of the adrenals. In 24 of them, the diagnosis was completely confirmed on histological examination of the excised tumor. The control group consisted of 19 healthy persons. All the investigations were performed on a MR tomograph BMT-1100 manufactured by Brucker Company (FRG) (0.235 T) according to the SE technique, with TR being 2 s and TE 34 ms. The visual picture together with a number of quantitative parameters (the time of spin-spin relaxation--T2, the index of relative signal intensity) were appraised. The method is shown to be highly informative in the diagnosis of pheochromocytomas, particularly of extra-adrenal site. In addition to a more prolonged T2, the high values of the index of relative signal intensity appeared very suggestive, especially on the 3d and 4th echo images.
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PMID:[The diagnosis of tumors of the chromaffin tissue by magnetic resonance tomography]. 262 52

99 patients with arterial hypertension (AH) were studied: 17 patients with pheochromocytoma, 37 with aldosteronoma, 4 with corticosteroma, 38 with essential hypertension. Control group included 16 healthy subjects. The investigation was performed by means of a NMR-tomograph BMT-1100 ("Brucker", FRG) in axial and frontal planes according to Spin Echo (SE) technique with TR = 2.0 s, TE = 34 ms. Qualitative (visual) as well as quantitative criteria for evaluation of adrenal glands state were developed. Normal size of adrenal glands, relative intensity of their signal and T2 were calculated. The data obtained proved that relative intensity of the signal is a highly informative parameter for differential diagnosis of adrenal gland tumors (its value of less than 1.0 is evidence of cortex lesion, and that of more than 1.4--of medulla lesion). High informative value of MR-tomography for evaluation of adrenal glands state in patients with AH is proved by comparative data obtained by other methods, such as computer tomography aortography and histomorphology.
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PMID:[Clinical use of magnetic resonance tomography for assessing adrenal function in patients with arterial hypertension]. 285 44