Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.67 (thiopurine methyltransferase)
 551 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
thiopurine S-methyltransferase 0.484
thiopurine methyltransferase 0.355
NUDT15 0.037
DPYD 0.003
TGN 0.003
glucosamine-6-phosphate deaminase 1 0.002
ITPA 0.002
RASGRP4 0.002
PACSIN2 0.001
SLCO1B1 0.001
VKORC1 0.001
SLC16A5 0.001
UGT1A1 0.001
inosine triphosphatase 0.001
dihydropyrimidine dehydrogenase 0.001
CYP2C9 0.001
BEC1 0.001
INPP1 0.001
solute carrier family 19 member 1 0.001
otospiralin 0.001
CYP2C19 0.001
ACYP2 0.001
AOF1 0.001
MT1L 0.001
HLAB 0.001
CYP2D6 0.000
SLC19A1 0.000
GlcNAc6ST-3 0.000
catechol O-methyltransferase 0.000
CYP3A5 0.000
MT1H 0.000
TRIM46 0.000
COMT 0.000
ITPase 0.000
MTHFR 0.000
molybdenum cofactor sulfurase 0.000
BEC2 0.000
equilibrative nucleoside transporter 2 0.000
KIF6 0.000
GST-5 0.000
CHST6 0.000
CBR3 0.000
allele c 0.000
NAT2 0.000
SLC28A3 0.000
NTP 0.000
ABCC3 0.000
SLC15A2 0.000
SEMA3C 0.000
cytochrome P4502D6 0.000
histamine N-methyltransferase 0.000
PGAM1 0.000
NUP153 0.000
TNFAIP2 0.000
KIF13A 0.000
ABCC4 0.000
SLCO1A2 0.000
DLG5 0.000
MT1X 0.000
inosine monophosphate dehydrogenase 0.000
TRIM59 0.000
UBE2D3 0.000
SAM-dependent methyltransferase 0.000
CYP4F3 0.000
SLC22A2 0.000
KPNB1 0.000
FLT3 receptor tyrosine kinase 0.000
ANXA3 0.000
CYP2A7 0.000
TYMS 0.000
MAPK7 0.000
ASNS 0.000
PRDX4 0.000
cytochrome P450 3A5 0.000
NT5C2 0.000
glucuronosyltransferase 0.000
CYP2B6 0.000
GSTT2 0.000
ABCC7 0.000
CYP2F1 0.000
EDARADD 0.000
ACAA 0.000
annexin A3 0.000
GSTA4 0.000
ABCC11 0.000
RFC1 0.000
MT1A 0.000
HLA-B gene 0.000
SBF2 0.000
CYP2A6 0.000
TPI1 0.000
HLA-B*1502 0.000
vitamin K epoxide reductase 0.000
MDR1 0.000
IL1R2 0.000
OPRT 0.000
phosphoglycerate mutase 1 0.000
MTG 0.000
CISD2 0.000
CARD15 0.000
UGT 0.000
MGR 0.000
PGK-2 0.000
FTH1 0.000
UDP-glucuronosyltransferase 1A1 0.000
Hsa 0.000
CYP4F2 0.000
ENPP1 0.000
XPD 0.000
UDPGT 0.000
CYP2C18 0.000
reduced folate carrier 0.000
IBD 0.000
ABCB1 0.000
ABCC5 0.000
CYP2C8 0.000
CYP3A7 0.000
EPHX1 0.000
hGR 0.000
cytochrome P450 2D6 0.000
NT5E 0.000
methylenetetrahydrofolate reductase 0.000
LRP2 0.000
hnRNP L 0.000
alpha-adducin 0.000
GSTP1 0.000
MGST1 0.000
HLA-DRB1*03 0.000
PDGFA 0.000
N-acetyltransferase 2 0.000
IL-28B 0.000
CYP3 0.000
UDP glucuronosyltransferase 0.000
MMP 0.000
Methionine adenosyltransferase 0.000
NAT 0.000
hCNT1 0.000
GSTM3 0.000
GSTM1 0.000
WFS1 0.000
peroxiredoxin 3 0.000
CYP3A4 0.000
ALL 0.000
1A1 0.000
G6PD 0.000
Nicotinamide N-methyltransferase 0.000
MRP4 0.000
UGT2B17 0.000
P1-450 0.000
UGT1A 0.000
GSTT1 0.000
FCGR2A 0.000
GluR-A 0.000
UGT1A7 0.000
HAS3 0.000
beta-mannosidase 0.000
malin 0.000
methyltransferase 0.000
IMPDH 0.000
UGT2B15 0.000
NNT 0.000
xanthine oxidase 0.000
ferritin heavy chain 0.000
GSTA1 0.000
DEK 0.000
cytochrome P450 0.000
CYP2E1 0.000
HAP1 0.000
TCH 0.000
Nod1 0.000
ADRB2 0.000
MTRR 0.000
HSPB1 0.000
5,10-methylenetetrahydrofolate reductase 0.000
B*15 0.000
P70 0.000
multidrug resistance protein 2 0.000
OATP2B1 0.000
NOD2 0.000
N-acetyltransferase 0.000
thymidylate synthase 0.000
folylpolyglutamate synthetase 0.000
multidrug resistance protein 0.000
SBS 0.000
NFE2L2 0.000
BCH 0.000
glucosamine-6-phosphate 0.000
Hsp25 0.000
PBX1 0.000
E2F3 0.000
HTR2A 0.000
betaglycan 0.000
FMO 0.000
ABCG2 0.000
OCT2 0.000
HES1 0.000
calcineurin 0.000
CDA 0.000
Stella 0.000
SOD2 0.000
IL28B 0.000
MTR 0.000
asparagine synthetase 0.000
CYP1 0.000
SULT1A1 0.000
AGO 0.000
OCT1 0.000
NOD1 0.000
CYP2 0.000
CETP 0.000
FES 0.000
VAMP 0.000
TGFBR2 0.000
NAT1 0.000
XRCC1 0.000
UGT1A9 0.000
organic cation transporter 0.000
MTD 0.000
HLA 0.000
RFC 0.000
pseudocholinesterase 0.000
ADH2 0.000
phenylethanolamine N-methyltransferase 0.000
hypoxanthine-guanine phosphoribosyltransferase 0.000
UGT2B7 0.000
ABCC2 0.000
B15 0.000
CYP2C 0.000
MPR 0.000
VDR 0.000
TOP2A 0.000
CYP1A2 0.000
MAF 0.000
breast cancer resistance protein 0.000
xenobiotic 0.000
OATP1B1 0.000
ARMS 0.000
organic anion transporter 0.000
ubiquitin-conjugating enzyme 0.000
CYP1A1 0.000
UDP-glucuronic acid 0.000
XPC 0.000
ALDH2 0.000
UDP-glucuronosyltransferase 0.000
SAM 0.000
SMN 0.000
CYP2B 0.000
hGH 0.000
P-glycoprotein 0.000
ecto-5'-nucleotidase 0.000
sulfotransferase 0.000
BCL2 0.000
megalin 0.000
DHFR 0.000
CYP 0.000
cytidine deaminase 0.000
myelo 0.000
MTX 0.000
non-functional 0.000
adenosine kinase 0.000
thymidylate synthetase 0.000
calpain inhibitor 0.000
stearoyl-CoA desaturase 0.000
ERCC1 0.000
MRP2 0.000
peroxisome proliferator-activated receptor alpha 0.000
BCRP 0.000
HLA-B 0.000
version 3 0.000
E2A 0.000
ATP-binding cassette 0.000
MT-2 0.000
MMR 0.000
NOTCH1 0.000
microsomal 0.000
triosephosphate isomerase 0.000
Glutathione S-transferase 0.000
FTO 0.000
IMP 0.000
AML1 0.000
quinone oxidoreductase 0.000
HLA-A 0.000
DCP 0.000
HSS 0.000
cholesteryl ester transfer protein 0.000
P450 0.000
glutathione S-transferase 0.000
IGF2 0.000
paraoxonase 0.000
beta-tubulin 0.000
L-asparaginase 0.000
GST 0.000
epoxide hydrolase 0.000
TEL 0.000
purine nucleoside phosphorylase 0.000
MOLT 0.000
ESR1 0.000
COL1A1 0.000
pregnane X receptor 0.000
solute carrier 0.000
pyrophosphatase 0.000
glutathione transferase 0.000
KRAS 0.000
glucocorticoid receptor 0.000
ACG 0.000
catechol-O-methyltransferase 0.000
natural killer cell 0.000
factor V Leiden 0.000
HLA-DRB1 0.000
FGFR1 0.000
ABL 0.000
GAP 0.000
proton pump 0.000
aldehyde dehydrogenase 0.000
calcineurin inhibitor 0.000
GTPase-activating protein 0.000
EGFR 0.000
methylguanine-DNA methyltransferase 0.000
PTEN 0.000
MLL 0.000
NQO1 0.000
dihydrofolate reductase 0.000
Cytochrome P450 0.000
EMA 0.000
ARF 0.000
P-gp 0.000
white cell 0.000
p13 0.000
APOE 0.000
B19 0.000
cytochrome P-450 0.000
CFTR 0.000
estrogen receptor alpha 0.000
tumor necrosis factor 0.000
PSS 0.000
HER2 0.000
CPT 0.000
flavoprotein 0.000
MRC 0.000
CYP3A 0.000
BAX 0.000
human leukocyte antigen 0.000
MAC 0.000
VIP 0.000
butyrylcholinesterase 0.000
topoisomerase I 0.000
serotonin transporter 0.000
cystic fibrosis transmembrane conductance regulator 0.000
RPMI 0.000
IL-23 0.000
KIT 0.000
SOD1 0.000
beta-globin 0.000
small GTPase 0.000
Mol 0.000
CXCL12 0.000
C18 0.000
Pseudomonas 0.000
glucose-6-phosphate dehydrogenase 0.000
ORF 0.000
ASA 0.000
BCR 0.000
TNF 0.000
thioredoxin 0.000
TLR4 0.000
granulocyte colony-stimulating factor 0.000
Sp1 0.000
metallothionein 0.000
oxidoreductase 0.000
transforming growth factor-beta 0.000
VIII 0.000
ACE 0.000
ABC 0.000
ICD 0.000
GM-CSF 0.000
Polymerase 0.000
BRCA1 0.000
epidermal growth factor receptor 0.000
NADPH 0.000
EGF 0.000
Sep 0.000
Men 0.000
DNA polymerase 0.000
alanine aminotransferase 0.000
osteosarcoma 0.000
Met 0.000
interferon-gamma 0.000
IFN 0.000
lysozyme 0.000
ATP 0.000
cytochrome 0.000
PEG 0.000
AKT 0.000
cytochrome c 0.000
NMR 0.000
threonine 0.000
mTOR 0.000
proteasome 0.000
reductase 0.000
hemoglobin 0.000
IgE 0.000
ubiquitin 0.000
p53 0.000
IL-10 0.000
cytokine 0.000
ADP 0.000
GSH 0.000
caspase-3 0.000
serum albumin 0.000
catalase 0.000
superoxide dismutase 0.000
albumin 0.000
endoplasmic reticulum 0.000
collagen 0.000
Gen 0.000
Disease
Thiopurine methyltransferase deficiency 0.009
Functional hearing loss 0.001
myelosuppression 0.001
Xanthine oxidase deficiency 0.001
inflammatory bowel disease 0.001
childhood ALL 0.000
acute lymphoblastic leukemia 0.000
Hypersensitivity syndrome 0.000
leukopenia 0.000
Crohn's disease 0.000
pancytopenia 0.000
ulcerative colitis 0.000
XPD 0.000
Ototoxicity 0.000
hypoprothrombinemia 0.000
DPD deficiency 0.000
pompholyx 0.000
enzyme deficiency 0.000
childhood cancer 0.000
leukemia 0.000
drug-induced hepatitis 0.000
Immune thrombocytopenia 0.000
Hepatotoxicity 0.000
SBS 0.000
SBS 0.000
neutropenia 0.000
pancreatitis 0.000
pemphigus 0.000
Inflammatory Bowel Disease 0.000
CDA 0.000
hepatic veno-occlusive disease 0.000
irritable bowel syndrome 0.000
minimal residual disease 0.000
secondary AML 0.000
hepatitis 0.000
BCH 0.000
Leukemia 0.000
Medulloblastoma 0.000
ACD 0.000
Gilbert 0.000
hypertrichosis 0.000
leukemogenesis 0.000
T-cell acute lymphoblastic leukemia 0.000
drug hypersensitivity 0.000
cancer 0.000
pemphigoid 0.000
HSS 0.000
Wegener's granulomatosis 0.000
torsades de pointes 0.000
Colitis 0.000
AIN 0.000
B-ALL 0.000
esophageal varices 0.000
autoimmune hemolytic anemia 0.000
agranulocytosis 0.000
lymphoproliferative disorders 0.000
prediabetes 0.000
ABL 0.000
hematologic malignancies 0.000
lupus nephritis 0.000
systemic lupus erythematosus 0.000
drug withdrawal 0.000
idiopathic pulmonary fibrosis 0.000
EMA 0.000
rheumatoid arthritis 0.000
rash 0.000
viral diarrhea 0.000
Bordetella 0.000
autoimmune disease 0.000
PSS 0.000
PSS 0.000
colitis 0.000
myasthenia gravis 0.000
thyrotoxicosis 0.000
opportunistic infection 0.000
yellow fever 0.000
immune deficiency 0.000
lymphoblastic leukemia 0.000
acute myeloid leukemia 0.000
stomatitis 0.000
acute leukemia 0.000
portal hypertension 0.000
dermatomyositis 0.000
thrombocytopenic purpura 0.000
CEM 0.000
psoriatic arthritis 0.000
lymphoma 0.000
medulloblastoma 0.000
thrombocytopenia 0.000
PSS 0.000
SLE 0.000
MAC 0.000
parvovirus 0.000
atopic dermatitis 0.000
ARF 0.000
aplastic anemia 0.000
uremia 0.000
cholangitis 0.000
idiopathic thrombocytopenic purpura 0.000
cirrhosis 0.000
Lupus 0.000
acute promyelocytic leukemia 0.000
Best 0.000
head and neck cancer 0.000
anaphylaxis 0.000
Graves' disease 0.000
genetic disorder 0.000
vasculitis 0.000
ICD 0.000
renal insufficiency 0.000
cholestasis 0.000
Steroids 0.000
tumor 0.000
confusion 0.000
thalassemia 0.000
multiple sclerosis 0.000
retinoblastoma 0.000
glucose intolerance 0.000
aggressiveness 0.000
skin cancer 0.000
cytomegalovirus 0.000
osteosarcoma 0.000
alcoholism 0.000
pertussis 0.000
chronic hepatitis 0.000
cholera 0.000
pancreatic cancer 0.000
psoriasis 0.000
hypoglycemia 0.000
virus infection 0.000
lupus 0.000
non-small cell lung cancer 0.000
anemia 0.000
dehydration 0.000
Epstein 0.000
influenza 0.000
breast cancer 0.000
sepsis 0.000
depression 0.000
suicide 0.000
herpes simplex 0.000
MCF 0.000
melanoma 0.000
liver disease 0.000
GSH 0.000
osteoporosis 0.000
hypertension 0.000
sepsis 0.000
colorectal cancer 0.000
pneumonia 0.000
tumorigenesis 0.000
type 2 diabetes 0.000
prostate cancer 0.000
myocardial infarction 0.000
cardiovascular disease 0.000
adenocarcinoma 0.000
arthritis 0.000
lung cancer 0.000
West 0.000
asthma 0.000
stroke 0.000
diabetes 0.000
Symptom
arthralgia 0.000
paresthesia 0.000
nausea and vomiting 0.000
splenomegaly 0.000
Ill 0.000
vomiting 0.000
tremor 0.000
angina 0.000
discomfort 0.000
nausea 0.000
discomfort 0.000
diarrhea 0.000
headache 0.000
seizures 0.000
pain 0.000
Drug
Mercaptopurine 0.001
Sulphasalazine 0.000
Monit 0.000
Infliximab 0.000
Infliximab 0.000
Neoral 0.000
Budesonide 0.000
TEL 0.000
Irinotecan 0.000
Prednisone 0.000
CTC 0.000
Etoposide 0.000
CTC 0.000
Tacrolimus 0.000
MRC 0.000
Glutathione 0.000
Mutagen 0.000
THF 0.000
ABC 0.000
caffeine 0.000
Dermatol 0.000
Enzyme
thiopurine methyltransferase 0.996
dihydropyrimidine dehydrogenase 0.001
dihydropyrimidine dehydrogenase 0.001
inosine triphosphatase 0.001
EC 3.6.1.19 0.001
thioether S-methyltransferase 0.001
catechol O-methyltransferase 0.000
TMT 0.000
histamine N-methyltransferase 0.000
S-adenosylhomocysteine nucleosidase 0.000
IMP dehydrogenase 0.000
nicotinamide N-methyltransferase 0.000
AFR 0.000
methylenetetrahydrofolate reductase 0.000
methylenetetrahydrofolate reductase 0.000
UDP-glucuronosyltransferase 0.000
NAT 0.000
nucleotide pyrophosphatase 0.000
MMP 0.000
CYP3A4 0.000
xanthine oxidase 0.000
nucleoside hydrolase 0.000
conjugase 0.000
thymidylate synthase 0.000
methionine adenosyltransferase 0.000
folylpolyglutamate synthetase 0.000
N-acetyltransferase 0.000
asparaginase 0.000
asparagine synthetase 0.000
phenylethanolamine N-methyltransferase 0.000
hypoxanthine-guanine phosphoribosyltransferase 0.000
SOR 0.000
P-glycoprotein 0.000
calcineurin 0.000
glutathione S-transferase 0.000
adenosine kinase 0.000
cytidine deaminase 0.000
flavin-containing monooxygenase 0.000
purine nucleoside phosphorylase 0.000
dihydrofolate reductase 0.000
paraoxonase 0.000
aldehyde dehydrogenase 0.000
aldehyde dehydrogenase 0.000
aldehyde dehydrogenase 0.000
paraoxonase 0.000
soluble epoxide hydrolase 0.000
aldehyde dehydrogenase 0.000
aldehyde dehydrogenase 0.000
cholinesterase 0.000
CPT 0.000
CPT 0.000
MDR 0.000
CPT 0.000
NQO1 0.000
glucose-6-phosphate dehydrogenase 0.000
ERK 0.000
ACE 0.000
focal adhesion kinase 0.000
DNA polymerase 0.000
lysozyme 0.000
alanine aminotransferase 0.000
acetylcholinesterase 0.000
proteasome 0.000
catalase 0.000
superoxide dismutase 0.000
Compound
Azathioprine 0.007
6-Mercaptopurine 0.003
PTMA 0.001
Dimethyl selenide 0.001
6-Thioguanine 0.001
MMPR 0.000
Acar 0.000
adenosylmethionine 0.000
ICRF-187 0.000
TCH 0.000
S-adenosylhomocysteine 0.000
Methotrexate 0.000
HEI 0.000
UDP 0.000
DEK 0.000
EAA 0.000
CDA 0.000
SN-38 0.000
uridine 0.000
methionine 0.000
Conjugated linoleic acid 0.000
Mycophenolate mofetil 0.000
methanethiol 0.000
TPD 0.000
IMP 0.000
TEL 0.000
DNA 0.000
Nodular 0.000
MTX 0.000
Clin 0.000
DCP 0.000
TTS 0.000
cinnamyl 0.000
HPP 0.000
tellurium 0.000
Prednisone 0.000
ubiquinol 0.000
DCP 0.000
DDP 0.000
ITP 0.000
GAP 0.000
UGA 0.000
Ciprofloxacin 0.000
Cyclosporine 0.000
ABL 0.000
pyrazine 0.000
benzamide 0.000
COS 0.000
CPT 0.000
VP-16 0.000
benzoic acid 0.000
CPT 0.000
Verapamil 0.000
Verapamil 0.000
Propranolol 0.000
2-mercaptoethanol 0.000
Propranolol 0.000
EDTA 0.000
Guo 0.000
MDR 0.000
homocysteine 0.000
GSSG 0.000
selenium 0.000
FK506 0.000
A 1 0.000
Yellow 0.000
BCR 0.000
Heparin 0.000
EDTA 0.000
TNF 0.000
NIDA 0.000
5-FU 0.000
2-oxoglutarate 0.000
dUTP 0.000
His 0.000
tryptophan 0.000
tryptophan 0.000
pyrene 0.000
TCA 0.000
tryptophan 0.000
caffeine 0.000
tryptophan 0.000
N-acetylcysteine 0.000
Dec 0.000
threonine 0.000
NADPH 0.000
NADPH 0.000
salicylic acid 0.000
ethyl acetate 0.000
acetonitrile 0.000
leucine 0.000
ASA 0.000
nicotinamide 0.000
glutamic acid 0.000
toluene 0.000
GSH 0.000
GSH 0.000
chloroform 0.000
aldehyde 0.000
pyrimidine 0.000
pyrimidine 0.000
ATP 0.000
arginine 0.000
aldehyde 0.000
creatinine 0.000
phenol 0.000
methanol 0.000
HCl 0.000
mercury 0.000
alanine 0.000
proline 0.000
cysteine 0.000
Gly 0.000
Asp 0.000
lysine 0.000
ADP 0.000
ADP 0.000
PEG 0.000
ADP 0.000
tyrosine 0.000
phosphate 0.000
PEG 0.000
iron 0.000
urea 0.000
serine 0.000
sodium 0.000
glutamate 0.000
nitric oxide 0.000
sulfate 0.000
acetate 0.000
glucose 0.000
water 0.000
oxygen 0.000