Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.67 (thiopurine methyltransferase)
 551 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
glucosamine-6-phosphate deaminase 1 15.8
thiopurine S-methyltransferase 15.6
thiopurine methyltransferase 15.4
NUDT15 14.9
RASGRP4 14.8
SLC16A5 13.5
PACSIN2 13.0
solute carrier family 19 member 1 12.8
INPP1 12.8
BEC1 12.8
otospiralin 12.6
ITPA 12.6
AOF1 12.4
MT1L 12.2
HLAB 12.2
inosine triphosphatase 12.2
DPYD 12.2
ACYP2 12.1
GlcNAc6ST-3 11.9
MT1H 11.7
TRIM46 11.6
TGN 11.4
molybdenum cofactor sulfurase 11.4
BEC2 11.3
equilibrative nucleoside transporter 2 11.3
ITPase 11.3
KIF6 11.2
SLCO1B1 11.2
CHST6 11.2
GST-5 11.2
VKORC1 11.1
allele c 11.1
SLC19A1 11.1
SLC28A3 11.1
SLC15A2 11.0
SEMA3C 11.0
CBR3 10.9
PGAM1 10.8
KIF13A 10.8
NUP153 10.8
TNFAIP2 10.8
cytochrome P4502D6 10.7
SLCO1A2 10.6
MT1X 10.5
DLG5 10.5
catechol O-methyltransferase 10.5
UBE2D3 10.5
TRIM59 10.5
SAM-dependent methyltransferase 10.4
CYP4F3 10.4
FLT3 receptor tyrosine kinase 10.4
KPNB1 10.4
histamine N-methyltransferase 10.4
ANXA3 10.3
UGT1A1 10.3
ABCC3 10.3
CYP2A7 10.3
MAPK7 10.2
SLC22A2 10.2
ASNS 10.1
dihydropyrimidine dehydrogenase 10.1
PRDX4 10.1
cytochrome P450 3A5 10.1
NT5C2 10.0
ABCC4 10.0
GSTT2 10.0
ABCC7 9.9
EDARADD 9.9
CYP2F1 9.9
ACAA 9.9
GSTA4 9.8
annexin A3 9.8
TYMS 9.8
ABCC11 9.7
MT1A 9.7
HLA-B gene 9.7
SBF2 9.6
inosine monophosphate dehydrogenase 9.6
TPI1 9.6
HLA-B*1502 9.6
CYP3A5 9.6
RFC1 9.5
IL1R2 9.5
OPRT 9.5
phosphoglycerate mutase 1 9.5
CISD2 9.4
NAT2 9.4
MGR 9.4
PGK-2 9.4
CYP2C9 9.4
FTH1 9.4
COMT 9.4
CYP2C19 9.3
MTG 9.2
MTHFR 9.2
UDPGT 9.2
CYP2C18 9.2
vitamin K epoxide reductase 9.1
UDP-glucuronosyltransferase 1A1 9.1
Hsa 9.1
CYP4F2 9.1
ABCC5 9.0
ENPP1 9.0
hGR 9.0
CARD15 9.0
NTP 8.9
glucuronosyltransferase 8.9
NT5E 8.9
LRP2 8.9
CYP2D6 8.9
hnRNP L 8.9
alpha-adducin 8.8
CYP3A7 8.8
EPHX1 8.8
MGST1 8.8
HLA-DRB1*03 8.8
PDGFA 8.7
UGT 8.7
reduced folate carrier 8.7
CYP3 8.6
UDP glucuronosyltransferase 8.6
N-acetyltransferase 2 8.6
IL-28B 8.5
cytochrome P450 2D6 8.5
Methionine adenosyltransferase 8.5
CYP2B6 8.5
hCNT1 8.5
GSTM3 8.5
CYP2A6 8.4
peroxiredoxin 3 8.4
Nicotinamide N-methyltransferase 8.3
XPD 8.3
UGT2B17 8.3
P1-450 8.3
FCGR2A 8.2
GluR-A 8.2
WFS1 8.2
UGT1A7 8.2
CYP2C8 8.2
HAS3 8.1
MRP4 8.1
UGT1A 8.1
NAT 8.1
beta-mannosidase 8.0
malin 8.0
IMPDH 7.9
UGT2B15 7.9
NNT 7.9
ferritin heavy chain 7.9
DEK 7.9
IBD 7.9
GSTA1 7.9
HAP1 7.8
TCH 7.8
Nod1 7.8
GSTP1 7.8
G6PD 7.7
methylenetetrahydrofolate reductase 7.7
ADRB2 7.6
HSPB1 7.6
5,10-methylenetetrahydrofolate reductase 7.6
B*15 7.6
MDR1 7.6
ABCB1 7.6
P70 7.6
MTRR 7.6
OATP2B1 7.5
multidrug resistance protein 2 7.5
folylpolyglutamate synthetase 7.5
SBS 7.4
GSTT1 7.4
NFE2L2 7.4
GSTM1 7.4
BCH 7.4
glucosamine-6-phosphate 7.4
Hsp25 7.4
PBX1 7.4
E2F3 7.3
1A1 7.3
HTR2A 7.3
multidrug resistance protein 7.2
betaglycan 7.2
FMO 7.2
OCT2 7.2
HES1 7.2
MMP 7.1
Stella 7.1
NOD2 7.1
IL28B 7.0
MTR 7.0
asparagine synthetase 7.0
CYP1 7.0
SULT1A1 7.0
AGO 7.0
OCT1 6.9
CDA 6.9
NOD1 6.9
CYP2 6.9
CETP 6.9
FES 6.9
VAMP 6.8
TGFBR2 6.8
NAT1 6.8
N-acetyltransferase 6.8
CYP2E1 6.8
UGT1A9 6.8
organic cation transporter 6.8
ALL 6.8
MTD 6.7
RFC 6.7
pseudocholinesterase 6.7
SOD2 6.7
CYP3A4 6.6
ADH2 6.6
XRCC1 6.6
thymidylate synthase 6.6
phenylethanolamine N-methyltransferase 6.6
UGT2B7 6.6
ABCC2 6.6
B15 6.6
CYP2C 6.5
MPR 6.5
ABCG2 6.5
TOP2A 6.5
MAF 6.5
OATP1B1 6.5
ARMS 6.5
organic anion transporter 6.4
ubiquitin-conjugating enzyme 6.4
VDR 6.4
breast cancer resistance protein 6.3
UDP-glucuronic acid 6.3
XPC 6.2
ALDH2 6.2
xanthine oxidase 6.2
SMN 6.2
CYP2B 6.2
hypoxanthine-guanine phosphoribosyltransferase 6.2
ecto-5'-nucleotidase 6.1
methyltransferase 6.0
UDP-glucuronosyltransferase 6.0
hGH 6.0
megalin 6.0
DHFR 5.9
cytidine deaminase 5.9
sulfotransferase 5.9
myelo 5.9
CYP1A2 5.9
adenosine kinase 5.9
thymidylate synthetase 5.8
calpain inhibitor 5.8
stearoyl-CoA desaturase 5.8
calcineurin 5.8
SAM 5.8
ERCC1 5.8
MRP2 5.7
MTX 5.7
CYP1A1 5.7
peroxisome proliferator-activated receptor alpha 5.7
BCL2 5.6
BCRP 5.6
version 3 5.6
E2A 5.6
MT-2 5.5
MMR 5.5
NOTCH1 5.5
triosephosphate isomerase 5.5
CYP 5.5
Glutathione S-transferase 5.5
cytochrome P450 5.5
FTO 5.5
non-functional 5.4
AML1 5.4
HLA-B 5.4
quinone oxidoreductase 5.4
DCP 5.4
HSS 5.4
cholesteryl ester transfer protein 5.3
IGF2 5.3
xenobiotic 5.3
paraoxonase 5.3
IMP 5.3
L-asparaginase 5.3
epoxide hydrolase 5.3
TEL 5.2
purine nucleoside phosphorylase 5.2
MOLT 5.2
ESR1 5.2
COL1A1 5.2
pregnane X receptor 5.2
solute carrier 5.2
pyrophosphatase 5.2
glutathione transferase 5.1
ATP-binding cassette 5.1
beta-tubulin 5.1
ACG 5.1
catechol-O-methyltransferase 5.0
factor V Leiden 5.0
HLA-A 5.0
HLA-DRB1 5.0
FGFR1 4.9
P-glycoprotein 4.9
GAP 4.9
natural killer cell 4.9
calcineurin inhibitor 4.9
ABL 4.8
GTPase-activating protein 4.8
aldehyde dehydrogenase 4.7
KRAS 4.7
methylguanine-DNA methyltransferase 4.7
MLL 4.7
NQO1 4.7
GST 4.6
Cytochrome P450 4.6
EMA 4.6
HLA 4.5
ARF 4.5
P-gp 4.5
P450 4.5
proton pump 4.5
dihydrofolate reductase 4.5
glucocorticoid receptor 4.5
glutathione S-transferase 4.4
white cell 4.4
p13 4.4
APOE 4.4
B19 4.4
CFTR 4.4
estrogen receptor alpha 4.3
PSS 4.3
PTEN 4.3
CPT 4.2
flavoprotein 4.2
MRC 4.1
CYP3A 4.1
BAX 4.1
EGFR 4.1
MAC 4.0
VIP 4.0
microsomal 4.0
butyrylcholinesterase 4.0
cytochrome P-450 3.9
topoisomerase I 3.9
serotonin transporter 3.9
cystic fibrosis transmembrane conductance regulator 3.9
human leukocyte antigen 3.9
RPMI 3.8
IL-23 3.8
KIT 3.8
SOD1 3.8
HER2 3.8
beta-globin 3.7
small GTPase 3.6
CXCL12 3.5
glucose-6-phosphate dehydrogenase 3.2
ORF 3.2
ASA 3.2
BCR 3.2
thioredoxin 3.0
granulocyte colony-stimulating factor 3.0
tumor necrosis factor 3.0
Sp1 3.0
C18 2.9
metallothionein 2.9
oxidoreductase 2.9
transforming growth factor-beta 2.9
TLR4 2.8
VIII 2.8
ACE 2.8
ABC 2.7
ICD 2.7
GM-CSF 2.7
Polymerase 2.7
BRCA1 2.6
EGF 2.4
epidermal growth factor receptor 2.3
Men 2.3
DNA polymerase 2.3
TNF 2.2
NADPH 2.2
Pseudomonas 2.2
alanine aminotransferase 2.1
osteosarcoma 2.0
Met 1.7
interferon-gamma 1.6
lysozyme 1.5
cytochrome 1.4
PEG 1.4
IFN 1.4
AKT 1.3
cytochrome c 1.3
threonine 1.2
mTOR 1.1
proteasome 1.1
reductase 1.1
Mol 1.0
hemoglobin 0.9
IgE 0.9
ubiquitin 0.8
ATP 0.8
IL-10 0.7
NMR 0.6
ADP 0.6
GSH 0.6
p53 0.6
caspase-3 0.3
serum albumin 0.3
catalase 0.3
cytokine 0.3
superoxide dismutase 0.2
albumin -0.1
endoplasmic reticulum -0.1
Sep -0.4
collagen -1.1
Gen -1.2
Disease
Thiopurine methyltransferase deficiency 15.8
Functional hearing loss 13.2
Xanthine oxidase deficiency 13.0
Hypersensitivity syndrome 11.4
childhood ALL 9.2
Ototoxicity 9.0
myelosuppression 9.0
hypoprothrombinemia 8.9
DPD deficiency 8.8
pompholyx 8.7
XPD 8.4
leukopenia 7.9
drug-induced hepatitis 7.8
inflammatory bowel disease 7.8
enzyme deficiency 7.7
acute lymphoblastic leukemia 7.6
Immune thrombocytopenia 7.5
pancytopenia 7.4
SBS 7.4
SBS 7.4
Hepatotoxicity 7.3
Inflammatory Bowel Disease 7.2
hepatic veno-occlusive disease 7.0
Crohn's disease 7.0
childhood cancer 6.9
CDA 6.9
secondary AML 6.6
ulcerative colitis 6.5
pemphigus 6.4
BCH 6.3
Medulloblastoma 6.2
ACD 6.0
Gilbert 5.9
minimal residual disease 5.9
hypertrichosis 5.9
irritable bowel syndrome 5.7
drug hypersensitivity 5.5
T-cell acute lymphoblastic leukemia 5.5
pancreatitis 5.4
neutropenia 5.4
leukemogenesis 5.4
HSS 5.3
torsades de pointes 5.2
AIN 5.2
pemphigoid 5.2
B-ALL 5.2
Wegener's granulomatosis 5.1
Colitis 5.0
autoimmune hemolytic anemia 5.0
esophageal varices 5.0
Leukemia 4.9
agranulocytosis 4.9
prediabetes 4.8
leukemia 4.8
lymphoproliferative disorders 4.8
ABL 4.7
lupus nephritis 4.6
drug withdrawal 4.6
hepatitis 4.5
EMA 4.5
viral diarrhea 4.4
hematologic malignancies 4.4
idiopathic pulmonary fibrosis 4.4
PSS 4.3
PSS 4.3
Bordetella 4.3
thyrotoxicosis 4.0
opportunistic infection 4.0
yellow fever 4.0
immune deficiency 4.0
myasthenia gravis 3.9
lymphoblastic leukemia 3.9
rash 3.8
dermatomyositis 3.8
thrombocytopenic purpura 3.8
CEM 3.8
psoriatic arthritis 3.7
stomatitis 3.7
acute leukemia 3.7
portal hypertension 3.7
medulloblastoma 3.6
colitis 3.6
autoimmune disease 3.5
SLE 3.5
MAC 3.5
PSS 3.4
systemic lupus erythematosus 3.4
parvovirus 3.3
ARF 3.3
aplastic anemia 3.3
uremia 3.3
cholangitis 3.3
atopic dermatitis 3.1
rheumatoid arthritis 3.1
idiopathic thrombocytopenic purpura 3.1
Lupus 3.1
acute myeloid leukemia 3.0
thrombocytopenia 2.9
acute promyelocytic leukemia 2.9
head and neck cancer 2.9
anaphylaxis 2.8
Best 2.7
Graves' disease 2.7
genetic disorder 2.7
ICD 2.6
renal insufficiency 2.6
cholestasis 2.6
Steroids 2.6
vasculitis 2.5
thalassemia 2.5
lymphoma 2.5
cirrhosis 2.5
confusion 2.4
retinoblastoma 2.4
glucose intolerance 2.3
aggressiveness 2.2
skin cancer 2.2
cytomegalovirus 2.0
multiple sclerosis 2.0
osteosarcoma 1.8
alcoholism 1.7
cancer 1.6
pertussis 1.6
chronic hepatitis 1.5
cholera 1.5
pancreatic cancer 1.5
psoriasis 1.5
hypoglycemia 1.4
lupus 1.4
non-small cell lung cancer 1.4
dehydration 1.3
Epstein 1.3
virus infection 1.2
anemia 1.2
suicide 1.1
herpes simplex 1.0
MCF 1.0
influenza 1.0
sepsis 1.0
liver disease 0.9
melanoma 0.7
GSH 0.6
osteoporosis 0.6
breast cancer 0.5
tumor 0.4
depression 0.4
sepsis 0.1
colorectal cancer 0.1
pneumonia 0.1
hypertension 0.0
tumorigenesis 0.0
type 2 diabetes 0.0
prostate cancer -0.0
myocardial infarction -0.2
cardiovascular disease -0.2
adenocarcinoma -0.2
arthritis -0.3
lung cancer -0.3
West -0.4
asthma -0.6
stroke -1.3
diabetes -2.3
Symptom
arthralgia 4.0
paresthesia 3.5
nausea and vomiting 2.6
splenomegaly 2.5
Ill 2.4
vomiting 1.9
tremor 1.6
angina 1.5
discomfort 1.4
nausea 1.3
discomfort 1.2
diarrhea 1.0
headache 0.0
seizures -0.5
pain -2.2
Drug
Mercaptopurine 12.5
Sulphasalazine 8.6
Neoral 6.8
Infliximab 6.7
Infliximab 6.7
Budesonide 6.5
TEL 6.2
Irinotecan 6.1
Prednisone 5.8
CTC 5.8
Etoposide 5.7
CTC 5.5
Tacrolimus 5.1
Monit 5.0
MRC 4.1
Glutathione 3.4
Mutagen 3.3
THF 2.8
ABC 2.7
caffeine 2.4
Dermatol 1.0
Enzyme
thiopurine methyltransferase 15.8
EC 3.6.1.19 12.4
thioether S-methyltransferase 12.4
inosine triphosphatase 11.1
catechol O-methyltransferase 10.4
dihydropyrimidine dehydrogenase 10.2
S-adenosylhomocysteine nucleosidase 10.2
dihydropyrimidine dehydrogenase 10.1
histamine N-methyltransferase 9.9
TMT 9.5
nicotinamide N-methyltransferase 9.3
AFR 9.2
IMP dehydrogenase 8.8
nucleotide pyrophosphatase 8.3
NAT 8.0
methylenetetrahydrofolate reductase 7.8
methylenetetrahydrofolate reductase 7.8
nucleoside hydrolase 7.7
conjugase 7.7
UDP-glucuronosyltransferase 7.4
methionine adenosyltransferase 7.4
folylpolyglutamate synthetase 7.4
MMP 6.9
asparagine synthetase 6.9
CYP3A4 6.6
N-acetyltransferase 6.6
thymidylate synthase 6.6
phenylethanolamine N-methyltransferase 6.6
asparaginase 6.4
SOR 6.3
xanthine oxidase 6.2
hypoxanthine-guanine phosphoribosyltransferase 6.1
adenosine kinase 6.0
cytidine deaminase 5.9
flavin-containing monooxygenase 5.7
purine nucleoside phosphorylase 5.3
paraoxonase 5.1
P-glycoprotein 4.9
dihydrofolate reductase 4.9
paraoxonase 4.8
calcineurin 4.8
aldehyde dehydrogenase 4.7
aldehyde dehydrogenase 4.7
soluble epoxide hydrolase 4.7
aldehyde dehydrogenase 4.7
glutathione S-transferase 4.5
aldehyde dehydrogenase 4.5
CPT 4.2
aldehyde dehydrogenase 4.1
CPT 4.1
cholinesterase 3.8
MDR 3.7
CPT 3.7
NQO1 3.2
glucose-6-phosphate dehydrogenase 2.9
ACE 2.7
focal adhesion kinase 2.0
ERK 1.9
DNA polymerase 1.8
lysozyme 1.4
alanine aminotransferase 1.1
acetylcholinesterase 1.0
proteasome 1.0
catalase 0.1
superoxide dismutase -0.0
Compound
Dimethyl selenide 13.0
PTMA 12.0
6-Mercaptopurine 11.9
Azathioprine 11.8
6-Thioguanine 11.4
MMPR 11.2
Acar 10.9
ICRF-187 8.2
TCH 7.7
HEI 7.3
DEK 7.2
EAA 7.2
CDA 6.9
Conjugated linoleic acid 6.8
S-adenosylhomocysteine 6.7
SN-38 6.7
Mycophenolate mofetil 6.6
adenosylmethionine 6.5
Methotrexate 6.3
methanethiol 6.3
TPD 6.2
TEL 6.2
UDP 6.0
Nodular 6.0
IMP 5.8
MTX 5.7
DCP 5.5
TTS 5.4
cinnamyl 5.4
uridine 5.3
HPP 5.3
tellurium 5.3
Prednisone 5.1
ubiquinol 5.1
DCP 4.9
ITP 4.8
GAP 4.8
UGA 4.7
Ciprofloxacin 4.7
DDP 4.5
Cyclosporine 4.5
pyrazine 4.4
ABL 4.3
methionine 4.3
benzamide 4.2
CPT 4.2
VP-16 4.2
CPT 4.1
Verapamil 4.0
Verapamil 3.9
benzoic acid 3.9
Propranolol 3.8
2-mercaptoethanol 3.8
COS 3.8
Propranolol 3.8
Guo 3.6
MDR 3.6
GSSG 3.4
FK506 3.3
homocysteine 3.3
A 1 3.2
Yellow 3.2
BCR 3.2
Heparin 3.1
EDTA 3.1
NIDA 3.1
5-FU 3.0
2-oxoglutarate 3.0
selenium 2.9
dUTP 2.9
TCA 2.7
EDTA 2.7
pyrene 2.5
N-acetylcysteine 2.4
caffeine 2.4
salicylic acid 2.4
tryptophan 2.3
tryptophan 2.3
tryptophan 2.3
TNF 2.2
NADPH 2.2
NADPH 2.2
ethyl acetate 2.1
DNA 2.1
tryptophan 2.1
threonine 2.0
ASA 1.9
His 1.9
acetonitrile 1.8
nicotinamide 1.8
glutamic acid 1.8
toluene 1.6
chloroform 1.6
aldehyde 1.6
Clin 1.5
pyrimidine 1.5
leucine 1.5
pyrimidine 1.5
GSH 1.5
GSH 1.5
aldehyde 1.2
phenol 1.1
HCl 1.1
mercury 1.1
creatinine 1.0
methanol 0.9
proline 0.9
arginine 0.8
ATP 0.8
Gly 0.8
Asp 0.7
alanine 0.7
cysteine 0.6
ADP 0.6
ADP 0.6
PEG 0.6
lysine 0.5
ADP 0.4
tyrosine 0.2
PEG 0.0
phosphate -0.0
urea -0.2
serine -0.2
iron -0.3
glutamate -0.3
Dec -0.4
sodium -0.7
nitric oxide -0.8
sulfate -1.0
acetate -1.0
glucose -1.4
water -2.0
oxygen -2.7