Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.67 (thiopurine methyltransferase)
 551 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
thiopurine S-methyltransferase 311
thiopurine methyltransferase 254
NUDT15 37
CYP2C9 33
CYP2D6 32
CYP2C19 30
UGT1A1 29
TGN 27
Sep 26
dihydropyrimidine dehydrogenase 23
Mol 22
cytochrome P450 19
VKORC1 18
SLCO1B1 17
DPYD 16
HLA 16
CYP3A5 15
MTHFR 15
COMT 15
NTP 14
methyltransferase 13
MDR1 13
xanthine oxidase 11
CYP3A4 11
ITPA 10
NAT2 10
ALL 10
ABCB1 9
microsomal 9
CYP2B6 9
MMP 9
tumor necrosis factor 8
calcineurin 8
methylenetetrahydrofolate reductase 7
xenobiotic 7
IBD 7
catechol O-methyltransferase 7
P-glycoprotein 7
CYP2A6 7
GSTP1 6
Pseudomonas 6
glucuronosyltransferase 6
GSTM1 6
1A1 6
CYP2E1 6
inosine triphosphatase 6
glutathione S-transferase 5
thymidylate synthase 5
CYP2C8 5
SLC19A1 5
XPD 5
GSTT1 5
inosine monophosphate dehydrogenase 5
P450 5
TNF 5
G6PD 4
ABCC4 4
CYP1A2 4
NMR 4
N-acetyltransferase 4
GST 4
ABCC3 4
glucocorticoid receptor 4
ATP 4
PACSIN2 4
EGFR 4
UGT 4
CYP1A1 4
ABCG2 4
ATP-binding cassette 3
SOD2 3
SAM 3
reduced folate carrier 3
KRAS 3
CARD15 3
proton pump 3
PTEN 3
HER2 3
BCL2 3
non-functional 3
CYP 3
NOD2 3
vitamin K epoxide reductase 3
hypoxanthine-guanine phosphoribosyltransferase 3
TYMS 3
NAT 3
cytokine 3
cytochrome P450 2D6 3
cytochrome P-450 3
histamine N-methyltransferase 3
C18 3
HLA-A 3
human leukocyte antigen 2
N-acetyltransferase 2 2
hGH 2
p53 2
multidrug resistance protein 2
MTX 2
SLC22A2 2
hemoglobin 2
IMP 2
UGT1A 2
CDA 2
ACYP2 2
sulfotransferase 2
SLC16A5 2
MTG 2
dihydrofolate reductase 2
epidermal growth factor receptor 2
IL-28B 2
UDP-glucuronosyltransferase 1A1 2
MRP4 2
ENPP1 2
Hsa 2
ABL 2
CYP4F2 2
CYP3A7 2
NADPH 2
XRCC1 2
natural killer cell 2
RFC1 2
ITPase 2
beta-tubulin 2
TLR4 2
CBR3 2
cytochrome P4502D6 2
IFN 2
UDP-glucuronosyltransferase 2
HLA-B 2
breast cancer resistance protein 2
aldehyde dehydrogenase 2
WFS1 2
ADRB2 2
EPHX1 2
MTRR 2
VDR 2
molybdenum cofactor sulfurase 1
DCP 1
ERCC1 1
NOD1 1
MAF 1
BEC1 1
Hsp25 1
hCNT1 1
CYP2 1
ORF 1
CYP2B 1
cytochrome 1
UGT1A9 1
ACG 1
UGT1A7 1
UDPGT 1
glucose-6-phosphate dehydrogenase 1
RFC 1
peroxisome proliferator-activated receptor alpha 1
BCR 1
caspase-3 1
MT-2 1
proteasome 1
Cytochrome P450 1
NT5E 1
OCT2 1
phosphoglycerate mutase 1 1
UGT2B7 1
NOTCH1 1
NNT 1
factor V Leiden 1
SLC15A2 1
Gen 1
endoplasmic reticulum 1
CYP2C18 1
GSTT2 1
PGAM1 1
KIF13A 1
VAMP 1
hGR 1
alpha-adducin 1
MOLT 1
calcineurin inhibitor 1
ubiquitin 1
glucosamine-6-phosphate deaminase 1 1
OATP1B1 1
L-asparaginase 1
HTR2A 1
peroxiredoxin 3 1
HLA-DRB1 1
FTH1 1
CYP2F1 1
stearoyl-CoA desaturase 1
oxidoreductase 1
CETP 1
catalase 1
annexin A3 1
BEC2 1
betaglycan 1
OATP2B1 1
HLA-B*1502 1
UDP-glucuronic acid 1
FES 1
paraoxonase 1
threonine 1
CYP2C 1
GSTA1 1
TCH 1
CYP3 1
OPRT 1
multidrug resistance protein 2 1
B19 1
thioredoxin 1
SLCO1A2 1
asparagine synthetase 1
TRIM59 1
osteosarcoma 1
BCH 1
beta-mannosidase 1
HLA-B gene 1
SULT1A1 1
HAP1 1
quinone oxidoreductase 1
HSS 1
PEG 1
pyrophosphatase 1
VIII 1
KIF6 1
ASA 1
MTD 1
DNA polymerase 1
methylguanine-DNA methyltransferase 1
Nod1 1
UGT2B15 1
BAX 1
thymidylate synthetase 1
serum albumin 1
flavoprotein 1
cystic fibrosis transmembrane conductance regulator 1
CFTR 1
MPR 1
ADH2 1
ABCC7 1
RPMI 1
AKT 1
malin 1
SAM-dependent methyltransferase 1
albumin 1
CXCL12 1
GAP 1
CISD2 1
B*15 1
OCT1 1
ABC 1
TNFAIP2 1
GSTM3 1
KIT 1
FTO 1
lysozyme 1
white cell 1
GlcNAc6ST-3 1
glutathione transferase 1
Nicotinamide N-methyltransferase 1
serotonin transporter 1
GluR-A 1
AOF1 1
ABCC5 1
IL1R2 1
Glutathione S-transferase 1
mTOR 1
APOE 1
GSTA4 1
RASGRP4 1
adenosine kinase 1
HES1 1
p13 1
SEMA3C 1
CPT 1
megalin 1
PGK-2 1
organic cation transporter 1
GTPase-activating protein 1
E2F3 1
organic anion transporter 1
SOD1 1
folylpolyglutamate synthetase 1
granulocyte colony-stimulating factor 1
TPI1 1
FLT3 receptor tyrosine kinase 1
interferon-gamma 1
FMO 1
FGFR1 1
ESR1 1
MT1L 1
superoxide dismutase 1
IL28B 1
HLAB 1
Polymerase 1
MRC 1
MAC 1
UBE2D3 1
DEK 1
VIP 1
E2A 1
allele c 1
INPP1 1
SBS 1
hnRNP L 1
ICD 1
epoxide hydrolase 1
equilibrative nucleoside transporter 2 1
phenylethanolamine N-methyltransferase 1
DHFR 1
HAS3 1
DLG5 1
MT1A 1
ubiquitin-conjugating enzyme 1
UDP glucuronosyltransferase 1
butyrylcholinesterase 1
MGR 1
glucosamine-6-phosphate 1
ferritin heavy chain 1
beta-globin 1
alanine aminotransferase 1
IgE 1
metallothionein 1
CYP1 1
TOP2A 1
GSH 1
TRIM46 1
ABCC11 1
NFE2L2 1
PDGFA 1
ANXA3 1
TGFBR2 1
SMN 1
IL-23 1
purine nucleoside phosphorylase 1
Methionine adenosyltransferase 1
COL1A1 1
MMR 1
IL-10 1
calpain inhibitor 1
NQO1 1
B15 1
version 3 1
5,10-methylenetetrahydrofolate reductase 1
ecto-5'-nucleotidase 1
UGT2B17 1
solute carrier family 19 member 1 1
topoisomerase I 1
P1-450 1
solute carrier 1
MT1H 1
cytidine deaminase 1
BCRP 1
GM-CSF 1
CYP2A7 1
SLC28A3 1
pseudocholinesterase 1
ASNS 1
ABCC2 1
cytochrome P450 3A5 1
HSPB1 1
FCGR2A 1
ADP 1
MGST1 1
cytochrome c 1
MT1X 1
AML1 1
small GTPase 1
EDARADD 1
reductase 1
PBX1 1
Stella 1
myelo 1
IGF2 1
CYP3A 1
AGO 1
BRCA1 1
MRP2 1
Sp1 1
PRDX4 1
MTR 1
GST-5 1
triosephosphate isomerase 1
IMPDH 1
NUP153 1
cholesteryl ester transfer protein 1
NT5C2 1
ACAA 1
otospiralin 1
KPNB1 1
ARF 1
CYP4F3 1
HLA-DRB1*03 1
collagen 1
ARMS 1
P-gp 1
PSS 1
transforming growth factor-beta 1
catechol-O-methyltransferase 1
EGF 1
XPC 1
ALDH2 1
pregnane X receptor 1
TEL 1
Men 1
estrogen receptor alpha 1
NAT1 1
EMA 1
P70 1
SBF2 1
MLL 1
Met 1
LRP2 1
CHST6 1
ACE 1
MAPK7 1
Disease
inflammatory bowel disease 88
acute lymphoblastic leukemia 74
cancer 56
myelosuppression 51
Crohn's disease 48
leukemia 45
leukopenia 30
ulcerative colitis 27
childhood ALL 25
tumor 16
pancytopenia 15
neutropenia 13
pancreatitis 12
hepatitis 12
childhood cancer 9
systemic lupus erythematosus 8
rheumatoid arthritis 8
Leukemia 8
irritable bowel syndrome 7
lymphoma 7
XPD 5
Thiopurine methyltransferase deficiency 5
acute myeloid leukemia 5
enzyme deficiency 5
pemphigus 5
autoimmune disease 5
minimal residual disease 5
colitis 4
thrombocytopenia 4
depression 4
rash 4
breast cancer 4
cirrhosis 4
leukemogenesis 3
hypertension 3
hematologic malignancies 3
multiple sclerosis 3
vasculitis 2
pemphigoid 2
Bordetella 2
portal hypertension 2
myasthenia gravis 2
acute leukemia 2
CDA 2
melanoma 2
ABL 2
stomatitis 2
PSS 2
T-cell acute lymphoblastic leukemia 2
confusion 2
idiopathic pulmonary fibrosis 2
Gilbert 2
sepsis 2
hypoprothrombinemia 2
lymphoproliferative disorders 2
ACD 2
esophageal varices 2
Ototoxicity 2
cytomegalovirus 2
lupus nephritis 2
Wegener's granulomatosis 2
Colitis 2
virus infection 2
Best 2
Hepatotoxicity 2
influenza 2
anemia 2
atopic dermatitis 2
agranulocytosis 2
West 1
lupus 1
adenocarcinoma 1
liver disease 1
psoriasis 1
Functional hearing loss 1
suicide 1
SLE 1
torsades de pointes 1
type 2 diabetes 1
skin cancer 1
Immune thrombocytopenia 1
prediabetes 1
GSH 1
Lupus 1
arthritis 1
BCH 1
psoriatic arthritis 1
myocardial infarction 1
herpes simplex 1
anaphylaxis 1
diabetes 1
Epstein 1
alcoholism 1
aplastic anemia 1
hypertrichosis 1
lung cancer 1
colorectal cancer 1
Hypersensitivity syndrome 1
tumorigenesis 1
autoimmune hemolytic anemia 1
idiopathic thrombocytopenic purpura 1
chronic hepatitis 1
EMA 1
MCF 1
cardiovascular disease 1
acute promyelocytic leukemia 1
stroke 1
drug withdrawal 1
MAC 1
opportunistic infection 1
genetic disorder 1
uremia 1
yellow fever 1
prostate cancer 1
secondary AML 1
pneumonia 1
pancreatic cancer 1
aggressiveness 1
thalassemia 1
drug-induced hepatitis 1
immune deficiency 1
drug hypersensitivity 1
SBS 1
Xanthine oxidase deficiency 1
thrombocytopenic purpura 1
CEM 1
head and neck cancer 1
glucose intolerance 1
PSS 1
PSS 1
sepsis 1
pertussis 1
hypoglycemia 1
hepatic veno-occlusive disease 1
AIN 1
parvovirus 1
Graves' disease 1
non-small cell lung cancer 1
renal insufficiency 1
DPD deficiency 1
medulloblastoma 1
ICD 1
osteoporosis 1
Inflammatory Bowel Disease 1
B-ALL 1
SBS 1
thyrotoxicosis 1
HSS 1
pompholyx 1
cholangitis 1
Steroids 1
osteosarcoma 1
retinoblastoma 1
dermatomyositis 1
lymphoblastic leukemia 1
dehydration 1
viral diarrhea 1
asthma 1
Medulloblastoma 1
ARF 1
cholera 1
cholestasis 1
Symptom
vomiting 2
diarrhea 2
arthralgia 2
splenomegaly 1
nausea 1
pain 1
paresthesia 1
Ill 1
discomfort 1
nausea and vomiting 1
headache 1
angina 1
tremor 1
discomfort 1
seizures 1
Drug
Monit 20
Dermatol 9
Mercaptopurine 4
Infliximab 2
Infliximab 2
caffeine 2
TEL 1
Etoposide 1
ABC 1
CTC 1
Budesonide 1
Irinotecan 1
Tacrolimus 1
Neoral 1
CTC 1
Sulphasalazine 1
Glutathione 1
Prednisone 1
Mutagen 1
THF 1
MRC 1
Enzyme
thiopurine methyltransferase 551
dihydropyrimidine dehydrogenase 23
dihydropyrimidine dehydrogenase 17
CYP3A4 11
xanthine oxidase 11
TMT 10
UDP-glucuronosyltransferase 10
glutathione S-transferase 9
catechol O-methyltransferase 9
MMP 9
methylenetetrahydrofolate reductase 8
calcineurin 8
methylenetetrahydrofolate reductase 8
P-glycoprotein 7
IMP dehydrogenase 7
ERK 6
thymidylate synthase 6
inosine triphosphatase 6
asparaginase 4
N-acetyltransferase 4
focal adhesion kinase 3
hypoxanthine-guanine phosphoribosyltransferase 3
NAT 3
histamine N-methyltransferase 3
cholinesterase 3
dihydrofolate reductase 3
aldehyde dehydrogenase 2
aldehyde dehydrogenase 2
aldehyde dehydrogenase 2
methionine adenosyltransferase 2
nucleotide pyrophosphatase 2
aldehyde dehydrogenase 2
aldehyde dehydrogenase 2
ACE 2
SOR 1
proteasome 1
asparagine synthetase 1
purine nucleoside phosphorylase 1
thioether S-methyltransferase 1
lysozyme 1
cytidine deaminase 1
CPT 1
conjugase 1
nucleoside hydrolase 1
acetylcholinesterase 1
paraoxonase 1
CPT 1
S-adenosylhomocysteine nucleosidase 1
phenylethanolamine N-methyltransferase 1
soluble epoxide hydrolase 1
glucose-6-phosphate dehydrogenase 1
CPT 1
superoxide dismutase 1
EC 3.6.1.19 1
adenosine kinase 1
alanine aminotransferase 1
MDR 1
paraoxonase 1
AFR 1
nicotinamide N-methyltransferase 1
DNA polymerase 1
catalase 1
flavin-containing monooxygenase 1
folylpolyglutamate synthetase 1
NQO1 1
Compound
Clin 78
Azathioprine 63
DNA 60
Dec 27
6-Mercaptopurine 26
methionine 20
adenosylmethionine 13
uridine 9
PTMA 7
Methotrexate 7
UDP 7
6-Thioguanine 6
TNF 5
S-adenosylhomocysteine 5
His 5
ATP 4
EDTA 4
tryptophan 3
phosphate 3
selenium 3
IMP 3
DDP 3
tryptophan 3
sodium 3
tryptophan 3
COS 3
EDTA 3
tryptophan 3
water 3
threonine 3
arginine 3
leucine 3
acetonitrile 2
cysteine 2
NADPH 2
SN-38 2
GSH 2
methanol 2
ABL 2
homocysteine 2
tyrosine 2
Cyclosporine 2
caffeine 2
NADPH 2
glucose 2
iron 2
creatinine 2
pyrene 2
benzoic acid 2
GSH 2
MTX 2
CDA 2
alanine 2
lysine 2
phenol 1
aldehyde 1
ubiquinol 1
oxygen 1
mercury 1
VP-16 1
acetate 1
Nodular 1
HCl 1
NIDA 1
FK506 1
ITP 1
PEG 1
BCR 1
TTS 1
benzamide 1
serine 1
ethyl acetate 1
nicotinamide 1
Heparin 1
GSSG 1
Verapamil 1
MDR 1
nitric oxide 1
Prednisone 1
MMPR 1
salicylic acid 1
ADP 1
DCP 1
DEK 1
2-oxoglutarate 1
EAA 1
sulfate 1
Yellow 1
Conjugated linoleic acid 1
5-FU 1
Gly 1
GAP 1
HPP 1
A 1 1
ADP 1
ICRF-187 1
PEG 1
cinnamyl 1
pyrimidine 1
CPT 1
Asp 1
urea 1
ASA 1
Propranolol 1
Mycophenolate mofetil 1
TEL 1
glutamate 1
Ciprofloxacin 1
2-mercaptoethanol 1
TPD 1
Dimethyl selenide 1
Guo 1
tellurium 1
Acar 1
chloroform 1
dUTP 1
TCH 1
methanethiol 1
CPT 1
pyrimidine 1
Verapamil 1
ADP 1
glutamic acid 1
Propranolol 1
DCP 1
TCA 1
proline 1
UGA 1
aldehyde 1
N-acetylcysteine 1
toluene 1
HEI 1
pyrazine 1