Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.67 (thiopurine methyltransferase)
 551 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
glucosamine-6-phosphate deaminase 1 15.8
thiopurine S-methyltransferase 15.6
thiopurine methyltransferase 15.4
NUDT15 14.9
RASGRP4 14.8
SLC16A5 13.5
PACSIN2 13.0
BEC1 12.8
INPP1 12.8
solute carrier family 19 member 1 12.8
otospiralin 12.6
ITPA 12.6
AOF1 12.4
HLAB 12.2
MT1L 12.2
inosine triphosphatase 12.2
DPYD 12.2
ACYP2 12.1
GlcNAc6ST-3 11.9
MT1H 11.7
TRIM46 11.6
TGN 11.4
molybdenum cofactor sulfurase 11.4
ITPase 11.3
equilibrative nucleoside transporter 2 11.3
BEC2 11.3
KIF6 11.2
SLCO1B1 11.2
CHST6 11.2
GST-5 11.2
VKORC1 11.1
allele c 11.1
SLC19A1 11.1
SLC28A3 11.1
SLC15A2 11.0
SEMA3C 11.0
CBR3 10.9
NUP153 10.8
TNFAIP2 10.8
PGAM1 10.8
more...
Disease
Thiopurine methyltransferase deficiency 15.8
Functional hearing loss 13.2
Xanthine oxidase deficiency 13.0
Hypersensitivity syndrome 11.4
childhood ALL 9.2
Ototoxicity 9.0
myelosuppression 9.0
hypoprothrombinemia 8.9
DPD deficiency 8.8
pompholyx 8.7
XPD 8.4
leukopenia 7.9
drug-induced hepatitis 7.8
inflammatory bowel disease 7.8
enzyme deficiency 7.7
acute lymphoblastic leukemia 7.6
Immune thrombocytopenia 7.5
pancytopenia 7.4
SBS 7.4
SBS 7.4
Hepatotoxicity 7.3
Inflammatory Bowel Disease 7.2
hepatic veno-occlusive disease 7.0
Crohn's disease 7.0
childhood cancer 6.9
CDA 6.9
secondary AML 6.6
ulcerative colitis 6.5
pemphigus 6.4
BCH 6.3
Medulloblastoma 6.2
ACD 6.0
Gilbert 5.9
minimal residual disease 5.9
hypertrichosis 5.9
irritable bowel syndrome 5.7
drug hypersensitivity 5.5
T-cell acute lymphoblastic leukemia 5.5
pancreatitis 5.4
neutropenia 5.4
more...
Symptom
arthralgia 4.0
paresthesia 3.5
nausea and vomiting 2.6
splenomegaly 2.5
Ill 2.4
vomiting 1.9
tremor 1.6
angina 1.5
discomfort 1.4
nausea 1.3
discomfort 1.2
diarrhea 1.0
headache 0.0
seizures -0.5
pain -2.2
Drug
Mercaptopurine 12.5
Sulphasalazine 8.6
Neoral 6.8
Infliximab 6.7
Infliximab 6.7
Budesonide 6.5
TEL 6.2
Irinotecan 6.1
Prednisone 5.8
CTC 5.8
Etoposide 5.7
CTC 5.5
Tacrolimus 5.1
Monit 5.0
MRC 4.1
Glutathione 3.4
Mutagen 3.3
THF 2.8
ABC 2.7
caffeine 2.4
Dermatol 1.0
Enzyme
thiopurine methyltransferase 15.8
thioether S-methyltransferase 12.4
EC 3.6.1.19 12.4
inosine triphosphatase 11.1
catechol O-methyltransferase 10.4
dihydropyrimidine dehydrogenase 10.2
S-adenosylhomocysteine nucleosidase 10.2
dihydropyrimidine dehydrogenase 10.1
histamine N-methyltransferase 9.9
TMT 9.5
nicotinamide N-methyltransferase 9.3
AFR 9.2
IMP dehydrogenase 8.8
nucleotide pyrophosphatase 8.3
NAT 8.0
methylenetetrahydrofolate reductase 7.8
methylenetetrahydrofolate reductase 7.8
nucleoside hydrolase 7.7
conjugase 7.7
UDP-glucuronosyltransferase 7.4
methionine adenosyltransferase 7.4
folylpolyglutamate synthetase 7.4
MMP 6.9
asparagine synthetase 6.9
CYP3A4 6.6
N-acetyltransferase 6.6
thymidylate synthase 6.6
phenylethanolamine N-methyltransferase 6.6
asparaginase 6.4
SOR 6.3
xanthine oxidase 6.2
hypoxanthine-guanine phosphoribosyltransferase 6.1
adenosine kinase 6.0
cytidine deaminase 5.9
flavin-containing monooxygenase 5.7
purine nucleoside phosphorylase 5.3
paraoxonase 5.1
P-glycoprotein 4.9
dihydrofolate reductase 4.9
paraoxonase 4.8
more...
Compound
Dimethyl selenide 13.0
PTMA 12.0
6-Mercaptopurine 11.9
Azathioprine 11.8
6-Thioguanine 11.4
MMPR 11.2
Acar 10.9
ICRF-187 8.2
TCH 7.7
HEI 7.3
DEK 7.2
EAA 7.2
CDA 6.9
Conjugated linoleic acid 6.8
S-adenosylhomocysteine 6.7
SN-38 6.7
Mycophenolate mofetil 6.6
adenosylmethionine 6.5
Methotrexate 6.3
methanethiol 6.3
TPD 6.2
TEL 6.2
UDP 6.0
Nodular 6.0
IMP 5.8
MTX 5.7
DCP 5.5
TTS 5.4
cinnamyl 5.4
uridine 5.3
HPP 5.3
tellurium 5.3
Prednisone 5.1
ubiquinol 5.1
DCP 4.9
ITP 4.8
GAP 4.8
UGA 4.7
Ciprofloxacin 4.7
DDP 4.5
more...