Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.1.1.67 (thiopurine methyltransferase)
551 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein thiopurine S-methyltransferase 311 thiopurine methyltransferase 254 NUDT15 37 CYP2C9 33 CYP2D6 32 CYP2C19 30 UGT1A1 29 TGN 27 Sep 26 dihydropyrimidine dehydrogenase 23 Mol 22 cytochrome P450 19 VKORC1 18 SLCO1B1 17 DPYD 16 HLA 16 MTHFR 15 CYP3A5 15 COMT 15 NTP 14 MDR1 13 methyltransferase 13 CYP3A4 11 xanthine oxidase 11 ITPA 10 ALL 10 NAT2 10 ABCB1 9 microsomal 9 MMP 9 CYP2B6 9 tumor necrosis factor 8 calcineurin 8 IBD 7 methylenetetrahydrofolate reductase 7 P-glycoprotein 7 catechol O-methyltransferase 7 CYP2A6 7 xenobiotic 7 glucuronosyltransferase 6 more...

Disease inflammatory bowel disease 88 acute lymphoblastic leukemia 74 cancer 56 myelosuppression 51 Crohn's disease 48 leukemia 45 leukopenia 30 ulcerative colitis 27 childhood ALL 25 tumor 16 pancytopenia 15 neutropenia 13 hepatitis 12 pancreatitis 12 childhood cancer 9 rheumatoid arthritis 8 Leukemia 8 systemic lupus erythematosus 8 lymphoma 7 irritable bowel syndrome 7 acute myeloid leukemia 5 enzyme deficiency 5 autoimmune disease 5 pemphigus 5 minimal residual disease 5 XPD 5 Thiopurine methyltransferase deficiency 5 rash 4 depression 4 colitis 4 cirrhosis 4 breast cancer 4 thrombocytopenia 4 multiple sclerosis 3 hypertension 3 leukemogenesis 3 hematologic malignancies 3 hypoprothrombinemia 2 melanoma 2 CDA 2 more...

Symptom vomiting 2 diarrhea 2 arthralgia 2 splenomegaly 1 nausea 1 pain 1 paresthesia 1 Ill 1 discomfort 1 nausea and vomiting 1 headache 1 angina 1 tremor 1 discomfort 1 seizures 1

Drug Monit 20 Dermatol 9 Mercaptopurine 4 Infliximab 2 Infliximab 2 caffeine 2 TEL 1 Etoposide 1 ABC 1 CTC 1 Budesonide 1 Irinotecan 1 Tacrolimus 1 Neoral 1 CTC 1 Sulphasalazine 1 Glutathione 1 Prednisone 1 Mutagen 1 THF 1 MRC 1

Enzyme thiopurine methyltransferase 551 dihydropyrimidine dehydrogenase 23 dihydropyrimidine dehydrogenase 17 CYP3A4 11 xanthine oxidase 11 UDP-glucuronosyltransferase 10 TMT 10 MMP 9 catechol O-methyltransferase 9 glutathione S-transferase 9 calcineurin 8 methylenetetrahydrofolate reductase 8 methylenetetrahydrofolate reductase 8 P-glycoprotein 7 IMP dehydrogenase 7 ERK 6 thymidylate synthase 6 inosine triphosphatase 6 asparaginase 4 N-acetyltransferase 4 focal adhesion kinase 3 hypoxanthine-guanine phosphoribosyltransferase 3 cholinesterase 3 NAT 3 histamine N-methyltransferase 3 dihydrofolate reductase 3 aldehyde dehydrogenase 2 aldehyde dehydrogenase 2 aldehyde dehydrogenase 2 methionine adenosyltransferase 2 nucleotide pyrophosphatase 2 aldehyde dehydrogenase 2 aldehyde dehydrogenase 2 ACE 2 proteasome 1 asparagine synthetase 1 purine nucleoside phosphorylase 1 thioether S-methyltransferase 1 lysozyme 1 cytidine deaminase 1 more...

Compound Clin 78 Azathioprine 63 DNA 60 Dec 27 6-Mercaptopurine 26 methionine 20 adenosylmethionine 13 uridine 9 Methotrexate 7 UDP 7 PTMA 7 6-Thioguanine 6 His 5 TNF 5 S-adenosylhomocysteine 5 EDTA 4 ATP 4 tryptophan 3 DDP 3 IMP 3 COS 3 tryptophan 3 phosphate 3 leucine 3 selenium 3 tryptophan 3 sodium 3 threonine 3 tryptophan 3 water 3 EDTA 3 arginine 3 MTX 2 NADPH 2 NADPH 2 caffeine 2 SN-38 2 GSH 2 pyrene 2 ABL 2 more...

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