Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.67 (thiopurine methyltransferase)
 551 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
thiopurine S-methyltransferase 311
thiopurine methyltransferase 254
NUDT15 37
CYP2C9 33
CYP2D6 32
CYP2C19 30
UGT1A1 29
TGN 27
Sep 26
dihydropyrimidine dehydrogenase 23
Mol 22
cytochrome P450 19
VKORC1 18
SLCO1B1 17
DPYD 16
HLA 16
MTHFR 15
COMT 15
CYP3A5 15
NTP 14
MDR1 13
methyltransferase 13
xanthine oxidase 11
CYP3A4 11
ALL 10
NAT2 10
ITPA 10
MMP 9
microsomal 9
CYP2B6 9
ABCB1 9
tumor necrosis factor 8
calcineurin 8
methylenetetrahydrofolate reductase 7
catechol O-methyltransferase 7
CYP2A6 7
P-glycoprotein 7
xenobiotic 7
IBD 7
inosine triphosphatase 6
Pseudomonas 6
glucuronosyltransferase 6
GSTP1 6
GSTM1 6
1A1 6
CYP2E1 6
glutathione S-transferase 5
CYP2C8 5
thymidylate synthase 5
XPD 5
P450 5
GSTT1 5
TNF 5
inosine monophosphate dehydrogenase 5
SLC19A1 5
ABCC3 4
ABCG2 4
EGFR 4
PACSIN2 4
N-acetyltransferase 4
GST 4
CYP1A1 4
UGT 4
G6PD 4
glucocorticoid receptor 4
ABCC4 4
ATP 4
NMR 4
CYP1A2 4
ATP-binding cassette 3
BCL2 3
PTEN 3
CYP 3
SAM 3
C18 3
NAT 3
cytokine 3
CARD15 3
HER2 3
TYMS 3
proton pump 3
HLA-A 3
non-functional 3
SOD2 3
hypoxanthine-guanine phosphoribosyltransferase 3
NOD2 3
KRAS 3
cytochrome P450 2D6 3
cytochrome P-450 3
reduced folate carrier 3
histamine N-methyltransferase 3
vitamin K epoxide reductase 3
N-acetyltransferase 2 2
hGH 2
p53 2
IMP 2
CYP3A7 2
CYP4F2 2
NADPH 2
beta-tubulin 2
CBR3 2
hemoglobin 2
aldehyde dehydrogenase 2
sulfotransferase 2
SLC22A2 2
human leukocyte antigen 2
UGT1A 2
ACYP2 2
IL-28B 2
UDP-glucuronosyltransferase 1A1 2
MRP4 2
ENPP1 2
Hsa 2
CDA 2
ABL 2
SLC16A5 2
MTG 2
natural killer cell 2
multidrug resistance protein 2
ITPase 2
TLR4 2
epidermal growth factor receptor 2
dihydrofolate reductase 2
VDR 2
MTRR 2
ADRB2 2
cytochrome P4502D6 2
IFN 2
HLA-B 2
RFC1 2
breast cancer resistance protein 2
WFS1 2
EPHX1 2
UDP-glucuronosyltransferase 2
MTX 2
XRCC1 2
molybdenum cofactor sulfurase 1
DCP 1
ERCC1 1
NOD1 1
MAF 1
BEC1 1
Hsp25 1
hCNT1 1
CYP2 1
ORF 1
CYP2B 1
cytochrome 1
UGT1A9 1
ACG 1
UGT1A7 1
UDPGT 1
glucose-6-phosphate dehydrogenase 1
RFC 1
peroxisome proliferator-activated receptor alpha 1
BCR 1
caspase-3 1
MT-2 1
proteasome 1
Cytochrome P450 1
NT5E 1
OCT2 1
phosphoglycerate mutase 1 1
UGT2B7 1
NOTCH1 1
NNT 1
factor V Leiden 1
SLC15A2 1
Gen 1
endoplasmic reticulum 1
CYP2C18 1
GSTT2 1
PGAM1 1
KIF13A 1
VAMP 1
hGR 1
alpha-adducin 1
MOLT 1
calcineurin inhibitor 1
ubiquitin 1
glucosamine-6-phosphate deaminase 1 1
OATP1B1 1
L-asparaginase 1
HTR2A 1
peroxiredoxin 3 1
HLA-DRB1 1
FTH1 1
CYP2F1 1
stearoyl-CoA desaturase 1
oxidoreductase 1
CETP 1
catalase 1
annexin A3 1
BEC2 1
betaglycan 1
ubiquitin-conjugating enzyme 1
MT1A 1
ferritin heavy chain 1
FES 1
paraoxonase 1
metallothionein 1
GSTA1 1
ABCC11 1
OPRT 1
TRIM46 1
B19 1
PDGFA 1
asparagine synthetase 1
BCH 1
SMN 1
version 3 1
5,10-methylenetetrahydrofolate reductase 1
HAP1 1
PEG 1
pyrophosphatase 1
VIII 1
KIF6 1
ecto-5'-nucleotidase 1
UGT2B17 1
topoisomerase I 1
DNA polymerase 1
UGT2B15 1
BAX 1
MT1H 1
MPR 1
ADH2 1
GM-CSF 1
MGST1 1
malin 1
EDARADD 1
CXCL12 1
GAP 1
Stella 1
IGF2 1
ABC 1
Sp1 1
FTO 1
GSTM3 1
white cell 1
GlcNAc6ST-3 1
glutathione transferase 1
Nicotinamide N-methyltransferase 1
PRDX4 1
GSTA4 1
RASGRP4 1
SEMA3C 1
CPT 1
MTR 1
B*15 1
ACAA 1
KPNB1 1
organic cation transporter 1
FLT3 receptor tyrosine kinase 1
interferon-gamma 1
KIT 1
GluR-A 1
PSS 1
AOF1 1
Polymerase 1
MRC 1
ABCC5 1
IL1R2 1
Glutathione S-transferase 1
mTOR 1
DEK 1
transforming growth factor-beta 1
VIP 1
ALDH2 1
Men 1
INPP1 1
adenosine kinase 1
epoxide hydrolase 1
equilibrative nucleoside transporter 2 1
phenylethanolamine N-methyltransferase 1
NAT1 1
p13 1
DLG5 1
E2F3 1
UDP glucuronosyltransferase 1
butyrylcholinesterase 1
organic anion transporter 1
MGR 1
glucosamine-6-phosphate 1
folylpolyglutamate synthetase 1
granulocyte colony-stimulating factor 1
TPI1 1
beta-globin 1
alanine aminotransferase 1
IgE 1
ESR1 1
MT1L 1
IL28B 1
HLAB 1
CYP1 1
TOP2A 1
MAC 1
TGFBR2 1
IL-23 1
purine nucleoside phosphorylase 1
Methionine adenosyltransferase 1
COL1A1 1
MMR 1
IL-10 1
calpain inhibitor 1
NQO1 1
B15 1
hnRNP L 1
HAS3 1
P1-450 1
solute carrier 1
cytidine deaminase 1
BCRP 1
CYP2A7 1
SLC28A3 1
ASNS 1
ABCC2 1
cytochrome P450 3A5 1
HSPB1 1
FCGR2A 1
MT1X 1
more...
Disease
inflammatory bowel disease 88
acute lymphoblastic leukemia 74
cancer 56
myelosuppression 51
Crohn's disease 48
leukemia 45
leukopenia 30
ulcerative colitis 27
childhood ALL 25
tumor 16
pancytopenia 15
neutropenia 13
pancreatitis 12
hepatitis 12
childhood cancer 9
systemic lupus erythematosus 8
rheumatoid arthritis 8
Leukemia 8
irritable bowel syndrome 7
lymphoma 7
XPD 5
Thiopurine methyltransferase deficiency 5
acute myeloid leukemia 5
enzyme deficiency 5
pemphigus 5
autoimmune disease 5
minimal residual disease 5
colitis 4
thrombocytopenia 4
depression 4
rash 4
breast cancer 4
cirrhosis 4
leukemogenesis 3
hypertension 3
hematologic malignancies 3
multiple sclerosis 3
vasculitis 2
pemphigoid 2
Bordetella 2
portal hypertension 2
myasthenia gravis 2
acute leukemia 2
CDA 2
melanoma 2
ABL 2
stomatitis 2
PSS 2
T-cell acute lymphoblastic leukemia 2
confusion 2
idiopathic pulmonary fibrosis 2
Gilbert 2
sepsis 2
hypoprothrombinemia 2
lymphoproliferative disorders 2
ACD 2
esophageal varices 2
Ototoxicity 2
cytomegalovirus 2
lupus nephritis 2
Wegener's granulomatosis 2
Colitis 2
virus infection 2
Best 2
Hepatotoxicity 2
influenza 2
anemia 2
atopic dermatitis 2
agranulocytosis 2
West 1
lupus 1
adenocarcinoma 1
liver disease 1
psoriasis 1
Functional hearing loss 1
suicide 1
SLE 1
torsades de pointes 1
type 2 diabetes 1
skin cancer 1
Immune thrombocytopenia 1
prediabetes 1
GSH 1
Lupus 1
arthritis 1
BCH 1
psoriatic arthritis 1
myocardial infarction 1
herpes simplex 1
anaphylaxis 1
diabetes 1
Epstein 1
alcoholism 1
aplastic anemia 1
hypertrichosis 1
lung cancer 1
colorectal cancer 1
Hypersensitivity syndrome 1
tumorigenesis 1
autoimmune hemolytic anemia 1
idiopathic thrombocytopenic purpura 1
chronic hepatitis 1
EMA 1
MCF 1
cardiovascular disease 1
acute promyelocytic leukemia 1
stroke 1
drug withdrawal 1
MAC 1
opportunistic infection 1
genetic disorder 1
uremia 1
yellow fever 1
prostate cancer 1
secondary AML 1
pneumonia 1
pancreatic cancer 1
aggressiveness 1
thalassemia 1
drug-induced hepatitis 1
immune deficiency 1
drug hypersensitivity 1
SBS 1
Xanthine oxidase deficiency 1
thrombocytopenic purpura 1
CEM 1
head and neck cancer 1
glucose intolerance 1
PSS 1
PSS 1
sepsis 1
pertussis 1
hypoglycemia 1
hepatic veno-occlusive disease 1
AIN 1
parvovirus 1
Graves' disease 1
non-small cell lung cancer 1
renal insufficiency 1
DPD deficiency 1
medulloblastoma 1
ICD 1
osteoporosis 1
Inflammatory Bowel Disease 1
B-ALL 1
SBS 1
thyrotoxicosis 1
HSS 1
pompholyx 1
cholangitis 1
Steroids 1
osteosarcoma 1
retinoblastoma 1
dermatomyositis 1
lymphoblastic leukemia 1
dehydration 1
viral diarrhea 1
asthma 1
Medulloblastoma 1
ARF 1
cholera 1
cholestasis 1
Symptom
vomiting 2
diarrhea 2
arthralgia 2
splenomegaly 1
nausea 1
pain 1
paresthesia 1
Ill 1
discomfort 1
nausea and vomiting 1
headache 1
angina 1
tremor 1
discomfort 1
seizures 1
Drug
Monit 20
Dermatol 9
Mercaptopurine 4
Infliximab 2
Infliximab 2
caffeine 2
TEL 1
Etoposide 1
ABC 1
CTC 1
Budesonide 1
Irinotecan 1
Tacrolimus 1
Neoral 1
CTC 1
Sulphasalazine 1
Glutathione 1
Prednisone 1
Mutagen 1
THF 1
MRC 1
Enzyme
thiopurine methyltransferase 551
dihydropyrimidine dehydrogenase 23
dihydropyrimidine dehydrogenase 17
CYP3A4 11
xanthine oxidase 11
TMT 10
UDP-glucuronosyltransferase 10
glutathione S-transferase 9
catechol O-methyltransferase 9
MMP 9
methylenetetrahydrofolate reductase 8
calcineurin 8
methylenetetrahydrofolate reductase 8
P-glycoprotein 7
IMP dehydrogenase 7
ERK 6
thymidylate synthase 6
inosine triphosphatase 6
asparaginase 4
N-acetyltransferase 4
focal adhesion kinase 3
hypoxanthine-guanine phosphoribosyltransferase 3
NAT 3
histamine N-methyltransferase 3
cholinesterase 3
dihydrofolate reductase 3
aldehyde dehydrogenase 2
aldehyde dehydrogenase 2
aldehyde dehydrogenase 2
methionine adenosyltransferase 2
nucleotide pyrophosphatase 2
aldehyde dehydrogenase 2
aldehyde dehydrogenase 2
ACE 2
SOR 1
proteasome 1
asparagine synthetase 1
purine nucleoside phosphorylase 1
thioether S-methyltransferase 1
lysozyme 1
cytidine deaminase 1
CPT 1
conjugase 1
nucleoside hydrolase 1
acetylcholinesterase 1
paraoxonase 1
CPT 1
S-adenosylhomocysteine nucleosidase 1
phenylethanolamine N-methyltransferase 1
soluble epoxide hydrolase 1
glucose-6-phosphate dehydrogenase 1
CPT 1
superoxide dismutase 1
EC 3.6.1.19 1
adenosine kinase 1
alanine aminotransferase 1
MDR 1
paraoxonase 1
AFR 1
nicotinamide N-methyltransferase 1
DNA polymerase 1
catalase 1
flavin-containing monooxygenase 1
folylpolyglutamate synthetase 1
NQO1 1
Compound
Clin 78
Azathioprine 63
DNA 60
Dec 27
6-Mercaptopurine 26
methionine 20
adenosylmethionine 13
uridine 9
PTMA 7
Methotrexate 7
UDP 7
6-Thioguanine 6
TNF 5
S-adenosylhomocysteine 5
His 5
ATP 4
EDTA 4
tryptophan 3
phosphate 3
selenium 3
IMP 3
DDP 3
tryptophan 3
sodium 3
tryptophan 3
COS 3
EDTA 3
tryptophan 3
water 3
threonine 3
arginine 3
leucine 3
acetonitrile 2
cysteine 2
NADPH 2
SN-38 2
GSH 2
methanol 2
ABL 2
homocysteine 2
tyrosine 2
Cyclosporine 2
caffeine 2
NADPH 2
glucose 2
iron 2
creatinine 2
pyrene 2
benzoic acid 2
GSH 2
MTX 2
CDA 2
alanine 2
lysine 2
phenol 1
aldehyde 1
ubiquinol 1
oxygen 1
mercury 1
VP-16 1
acetate 1
Nodular 1
HCl 1
NIDA 1
FK506 1
ITP 1
PEG 1
BCR 1
TTS 1
benzamide 1
serine 1
ethyl acetate 1
nicotinamide 1
Heparin 1
GSSG 1
Verapamil 1
MDR 1
nitric oxide 1
Prednisone 1
MMPR 1
salicylic acid 1
ADP 1
DCP 1
DEK 1
2-oxoglutarate 1
EAA 1
sulfate 1
Yellow 1
Conjugated linoleic acid 1
5-FU 1
Gly 1
GAP 1
HPP 1
A 1 1
ADP 1
ICRF-187 1
PEG 1
cinnamyl 1
pyrimidine 1
CPT 1
Asp 1
urea 1
ASA 1
Propranolol 1
Mycophenolate mofetil 1
TEL 1
glutamate 1
Ciprofloxacin 1
2-mercaptoethanol 1
TPD 1
Dimethyl selenide 1
Guo 1
tellurium 1
Acar 1
chloroform 1
dUTP 1
TCH 1
methanethiol 1
CPT 1
pyrimidine 1
Verapamil 1
ADP 1
glutamic acid 1
Propranolol 1
DCP 1
TCA 1
proline 1
UGA 1
aldehyde 1
N-acetylcysteine 1
toluene 1
HEI 1
pyrazine 1