Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.67 (thiopurine methyltransferase)
 551 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
thiopurine S-methyltransferase 311
thiopurine methyltransferase 254
NUDT15 37
CYP2C9 33
CYP2D6 32
CYP2C19 30
UGT1A1 29
TGN 27
Sep 26
dihydropyrimidine dehydrogenase 23
Mol 22
cytochrome P450 19
VKORC1 18
SLCO1B1 17
HLA 16
DPYD 16
MTHFR 15
CYP3A5 15
COMT 15
NTP 14
more...
Disease
inflammatory bowel disease 88
acute lymphoblastic leukemia 74
cancer 56
myelosuppression 51
Crohn's disease 48
leukemia 45
leukopenia 30
ulcerative colitis 27
childhood ALL 25
tumor 16
pancytopenia 15
neutropenia 13
pancreatitis 12
hepatitis 12
childhood cancer 9
rheumatoid arthritis 8
systemic lupus erythematosus 8
Leukemia 8
irritable bowel syndrome 7
lymphoma 7
more...
Symptom
vomiting 2
diarrhea 2
arthralgia 2
splenomegaly 1
nausea 1
pain 1
paresthesia 1
Ill 1
discomfort 1
nausea and vomiting 1
headache 1
angina 1
tremor 1
discomfort 1
seizures 1
Drug
Monit 20
Dermatol 9
Mercaptopurine 4
Infliximab 2
Infliximab 2
caffeine 2
TEL 1
Etoposide 1
ABC 1
CTC 1
Budesonide 1
Irinotecan 1
Tacrolimus 1
Neoral 1
CTC 1
Sulphasalazine 1
Glutathione 1
Prednisone 1
Mutagen 1
THF 1
more...
Enzyme
thiopurine methyltransferase 551
dihydropyrimidine dehydrogenase 23
dihydropyrimidine dehydrogenase 17
xanthine oxidase 11
CYP3A4 11
UDP-glucuronosyltransferase 10
TMT 10
catechol O-methyltransferase 9
MMP 9
glutathione S-transferase 9
methylenetetrahydrofolate reductase 8
methylenetetrahydrofolate reductase 8
calcineurin 8
P-glycoprotein 7
IMP dehydrogenase 7
ERK 6
thymidylate synthase 6
inosine triphosphatase 6
asparaginase 4
N-acetyltransferase 4
more...
Compound
Clin 78
Azathioprine 63
DNA 60
Dec 27
6-Mercaptopurine 26
methionine 20
adenosylmethionine 13
uridine 9
UDP 7
Methotrexate 7
PTMA 7
6-Thioguanine 6
His 5
S-adenosylhomocysteine 5
TNF 5
ATP 4
EDTA 4
COS 3
tryptophan 3
IMP 3
more...