Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.37 (DNA methyltransferase)
 4,983 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
DNA methyltransferase 4358
DNMT1 579
Mol 555
histone 550
methyltransferase 450
histone deacetylase 429
Sep 312
endonuclease 297
Dnmt1 259
DNMT3A 234
DNMT3B 212
DNA methylase 204
Dnmt3a 173
histone H3 155
p53 126
Dnmt3b 98
methylguanine-DNA methyltransferase 67
telomeric 67
Rett syndrome 61
cytokine 61
p21 58
p16 56
E-cadherin 55
histone methyltransferase 53
estrogen receptor 51
polypeptide 46
DNMT3L 44
GATC 42
CD4 41
HDAC1 41
Dnmt2 40
fused 39
DNA repair protein 38
DNMT2 37
DAC 36
insulin 36
Sp1 35
DNA repair enzyme 34
tumour suppressor 33
HDAC 33
MET1 33
ubiquitin 31
lymphoid 31
histone acetyltransferase 31
EZH2 31
caspase-3 31
Adenosine deaminase 31
proliferating cell nuclear antigen 31
IFN 30
Gen 29
ATP 29
erythroid 28
RASSF1A 28
catenin 27
tRNA 27
Bcl-2 27
interferon 26
histone H4 26
thymus 26
MBD2 26
mer 26
AML 26
proteasome 24
IDH1 24
Histone deacetylase 23
transcriptional repressor 23
OCT4 22
RNA polymerase II 22
ERK 22
mTOR 22
UTR 22
histone deacetylase 1 22
p15 22
CD34 21
ATPase 21
p16INK4a 21
IL-6 21
DNA-binding protein 21
TET2 21
brain-derived neurotrophic factor 20
CD8 20
Methylguanine-DNA methyltransferase 20
STAT3 19
MAPK 19
INK4a 19
TNF 19
insulin receptor substrate 18
unknown function 18
MEK 18
AKT 18
O6-methylguanine-DNA methyltransferase 18
proto-oncogene 18
PI3K 18
SDS 18
BRAF 17
isocitrate dehydrogenase 17
helicase 17
cage 17
TET1 17
G9a 17
collagen 17
ras 16
X-chromosome 16
lipopolysaccharide 16
PARP 16
TSA 16
IDH2 16
progesterone receptor 16
CDKN2A 16
MYC 16
epidermal growth factor receptor 16
DNase I 15
Pol 15
SAM 15
tyrosine kinase 15
SGI 15
PTEN 15
HDAC2 15
MLL 15
hemoglobin 15
MBD1 15
glutathione S-transferase 15
ATM 15
UHRF1 15
HP1 14
c-myc 14
X-linked 14
isocitrate dehydrogenase 1 14
all-trans 14
zinc finger 14
superoxide dismutase 14
Reelin 13
STAT 13
glucocorticoid receptor 13
GSTP1 13
LSD1 13
PHD domain 13
hMLH1 13
Pseudomonas 13
Oct4 13
tumor necrosis factor 13
SWI 13
FLT3 13
transcriptional regulator 13
SOX2 13
H2AX 13
CDH1 13
P-glycoprotein 12
p300 12
IFN-gamma 12
MAGE 12
phosphatase and tensin homolog 12
Cx32 12
NMR 12
APC 12
vascular endothelial growth factor 12
BRCA1 12
EGFR 12
matrix metalloproteinase 12
FOXP3 12
more...
Disease
cancer 1162
tumor 808
carcinogenesis 260
tumorigenesis 197
acute myeloid leukemia 182
breast cancer 174
leukemia 144
myelodysplastic syndrome 126
carcinoma 106
colorectal cancer 104
glioblastoma 84
hepatocellular carcinoma 81
glioma 74
lung cancer 72
prostate cancer 66
tumor progression 66
tumor growth 65
MCF 61
immunodeficiency 60
gastric cancer 54
colon cancer 52
melanoma 45
adenocarcinoma 42
ovarian cancer 37
lymphoma 35
Leukemia 33
hematologic malignancies 31
diabetes 31
atherosclerosis 28
leukemogenesis 28
multiple myeloma 28
Alzheimer's disease 26
pancreatic cancer 26
squamous cell carcinoma 25
systemic lupus erythematosus 25
glioblastoma multiforme 23
non-small cell lung cancer 23
metastases 23
brain tumor 21
lupus 21
lupus 20
B-cell lymphoma 20
Epstein 19
acute lymphoblastic leukemia 19
obesity 19
SDS 18
cervical cancer 18
epithelial ovarian cancer 17
cold 17
erythroleukemia 17
Haemophilus 17
bladder cancer 17
retinoblastoma 16
ATM 16
CHH 16
Burkitt's lymphoma 15
HIV 15
schizophrenia 15
sarcoma 15
neuroblastoma 15
liver cancer 14
APC 14
aggressiveness 14
myelosuppression 14
HP1 14
acute leukemia 14
DSS 13
virus infection 13
chronic myeloid leukemia 13
infectious diseases 13
endometrial cancer 13
hepatitis B 13
liver cancer 12
cytomegalovirus 12
sickle cell disease 12
hypertension 12
Glioblastoma 11
chronic myelomonocytic leukemia 11
suicide 11
GSH 11
cirrhosis 11
depression 11
myeloproliferative disorders 11
SCID 10
chronic hepatitis 10
lung carcinoma 10
NOD 10
primary tumor 10
embryonal carcinoma 10
acute promyelocytic leukemia 10
adenoma 10
chronic lymphocytic leukemia 9
stroke 9
infertility 9
solid tumor 9
oligodendroglioma 9
neoplastic transformation 9
myeloid leukemia 9
ischemia 9
MDS 9
skin cancer 9
osteosarcoma 9
Hodgkin's disease 9
renal cell carcinoma 9
Infection 9
Mycoplasma 9
Rett syndrome 8
malnutrition 8
minimal residual disease 8
rheumatoid arthritis 8
Melanoma 8
medulloblastoma 8
cognitive impairment 8
hyperhomocysteinemia 8
thalassemia 8
thrombocytopenia 7
AIDS 7
esophageal cancer 7
folate deficiency 7
Plaque 7
chronic pain 7
fibrosarcoma 7
hepatitis C 7
colitis 7
mastocytoma 7
Brown 7
CEM 7
Sotos syndrome 7
hyperglycemia 7
anemia 7
neutropenia 7
T-cell lymphoma 7
thyroid cancer 7
ATRX 7
Klebsiella 7
Shigella sonnei 7
Parkinson's disease 7
chronic lymphocytic leukemia 7
rhabdomyosarcoma 7
small cell lung cancer 6
WT1 6
ADD 6
Blocking 6
brain metastases 6
autism 6
addiction 6
autoimmune disease 6
herpes simplex 6
preeclampsia 6
tumor initiation 6
cardiovascular disease 6
chronic obstructive pulmonary disease 6
tuberculosis 6
T-cell lymphomas 6
cutaneous T-cell lymphoma 6
type 2 diabetes 6
osteoarthritis 6
laryngeal squamous cell carcinoma 6
epilepsy 6
coronary artery disease 6
more...
Symptom
pain 21
starvation 8
seizures 6
nausea 6
exhaustion 6
fatigue 5
diarrhea 4
cerebellar ataxia 3
ataxia 2
Neuropathic pain 2
functional recovery 2
pelvic pain 2
sleepiness 2
collapse 2
vomiting 2
hypotonia 2
headache 2
dysuria 1
hip pain 1
ACHE 1
thinning 1
cachexia 1
hoarseness 1
bone pain 1
stigma 1
dizziness 1
twitching 1
anorexia 1
masculinization 1
constipation 1
splenomegaly 1
hypersomnia 1
acute pain 1
tremor 1
hyperoxia 1
discomfort 1
weakness 1
numbness 1
Ill 1
cough 1
shortness of breath 1
respiratory distress 1
hepatomegaly 1
rigors 1
hepatosplenomegaly 1
hypothermia 1
Drug
lysine 149
Zebularine 28
Azacytidine 17
Gel 16
DNase I 15
IFN-gamma 11
MDS 9
Dacogen 8
Epigallocatechin 8
ROS 8
IL-2 8
ascorbate 6
Mutagen 6
Dermatol 6
-deoxyadenosine 5
Asn 5
THF 5
ABC 5
MAP 5
GEO 4
NADH 4
ampicillin 4
ETS 4
Bifidobacterium 4
caffeine 4
Retinoic acid 3
Glutathione 3
lactose 3
Leaf 3
AGG 3
DMI 3
CSF 3
ICI 3
Arsenic trioxide 3
Docetaxel 2
VCR 2
Lenalidomide 2
Monit 2
Ethanol 2
Biopolymers 2
Methylene blue 2
CaCl2 2
CaCl2 2
CaCl2 2
CFT 2
Alanine 2
CPT-11 2
Adriamycin 2
TAT 2
BLM 1
Genasense 1
Honey 1
Verteporfin 1
Erlotinib 1
Pronase 1
ID2 1
Vorinostat 1
APM 1
Alliance 1
Adenosine deaminase 1
balanced salt solution 1
Growth hormone 1
NH3 1
Indomethacin 1
Dasatinib 1
MOF 1
NBT 1
Sorafenib 1
SiO2 1
Gliadel 1
Asthma 1
CDP 1
beta-Galactosidase 1
FLP 1
Cilengitide 1
Vitamin A 1
Gefitinib 1
Mirtazapine 1
Capsicum 1
Temodal 1
uPA 1
TTC 1
PMEA 1
Sinefungin 1
Bexarotene 1
Clofibrate 1
EE2 1
AC2 1
Doxycycline 1
Imatinib 1
Taxotere 1
Gleevec 1
PTC 1
ACT 1
ADR 1
Growth hormone 1
Artesunate 1
Irinotecan 1
TAC 1
PCB 1
p75 1
ATV 1
ADM 1
Fulvestrant 1
Adenyl 1
Fraction 1
Paraffin 1
Fragment 1
Colistin 1
Oxaliplatin 1
Angiotensin II 1
HCH 1
Emodin 1
Emodin 1
nitroglycerin 1
TAK 1
Bortezomib 1
Meth 1
DMAP 1
IFN-beta 1
Dihydro 1
G418 1
Urokinase 1
Taxol 1
Enzyme
DNA methyltransferase 4983
restriction-modification system 349
deoxyribonuclease 306
endonuclease 297
ERK 78
luciferase 54
demethylase 53
RNA polymerase 53
mitogen-activated protein kinase 47
DNA ligase 39
DNA ligase 39
histone acetyltransferase 38
focal adhesion kinase 34
protein kinase 33
proteasome 25
glutathione S-transferase 24
ATPase 22
PARP 20
topoisomerase 20
MEK 20
topoisomerase 19
reverse transcriptase 18
DNA polymerase 18
isocitrate dehydrogenase 17
isocitrate dehydrogenase 17
caspase-3 16
DNase 16
TSA 16
histone demethylase 15
superoxide dismutase 15
RNase 13
APC 13
RNase 12
P-glycoprotein 12
transcriptase 12
cytidine deaminase 11
catalase 10
PHD 10
trypsin 9
micrococcal nuclease 8
peroxidase 8
phosphoglycerate kinase 8
ACS 8
alkaline phosphatase 8
calcineurin 8
phosphoinositide 3-kinase 8
chloramphenicol acetyltransferase 7
ornithine decarboxylase 7
phosphatidylinositol 3-kinase 7
cdc2 7
thymidylate synthase 7
invertase 6
thymidine kinase 6
methionine synthase 6
NO synthase 6
NQO1 6
methionine synthase 6
protein kinase C 6
ribonucleotide reductase 5
beta-galactosidase 5
AMP-activated protein kinase 5
caspase-9 5
farnesyltransferase 5
farnesyltransferase 5
aldehyde dehydrogenase 4
aldehyde dehydrogenase 4
MMP 4
aldehyde dehydrogenase 4
glyceraldehyde-3-phosphate dehydrogenase 4
PDK1 4
methionine adenosyltransferase 4
aldehyde dehydrogenase 4
aldehyde dehydrogenase 4
lysozyme 4
methylenetetrahydrofolate reductase 4
ribonuclease 4
S-adenosylmethionine decarboxylase 4
deaminase 4
dihydrofolate reductase 4
ribonuclease 4
AlkA 4
S1 nuclease 4
methylenetetrahydrofolate reductase 4
NOS 4
glycine N-methyltransferase 4
catechol O-methyltransferase 3
phosphoenolpyruvate carboxykinase 3
EC 2.1.1.72 3
MAP 3
phosphoenolpyruvate carboxykinase 3
glucose oxidase 3
RNase H 3
lactate dehydrogenase 3
GSK 3
renin 3
AMPK 3
phosphatidylethanolamine N-methyltransferase 3
histone-lysine N-methyltransferase 3
glutathione peroxidase 3
caspase-8 3
granzyme B 3
phosphoenolpyruvate carboxykinase 3
AMPK 3
deoxyribonuclease 3
acetylcholinesterase 2
dCMP deaminase 2
soluble epoxide hydrolase 2
hexokinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
glyceraldehyde-3-phosphate dehydrogenase 2
ribonucleotide reductase 2
glyceraldehyde-3-phosphate dehydrogenase 2
gamma-glutamyl transpeptidase 2
CD10 2
MDR 2
IKK 2
heme oxygenase 2
pyruvate kinase 2
aspartate aminotransferase 2
PRA 2
elastase 2
TAT 2
matrix metalloproteinase 2 2
lysyl oxidase 2
adenine phosphoribosyltransferase 2
HSD 2
hypoxanthine-guanine phosphoribosyltransferase 2
PAM 2
tyrosine hydroxylase 2
beta-glucuronidase 2
phenylethanolamine N-methyltransferase 2
CYP3A4 2
TMT 2
protein phosphatase 2A 2
caspase-7 2
firefly luciferase 2
GCA 2
chymotrypsin 2
methioninase 2
glyceraldehyde-3-phosphate dehydrogenase 2
type II restriction enzyme 2
MMP-3 2
glutaminase 2
HK2 2
urokinase-type plasminogen activator 2
UDP-glucuronosyltransferase 2
phosphatidylinositol-4,5-bisphosphate 3-kinase 2
dihydropyrimidine dehydrogenase 2
sucrase 2
deoxycytidine kinase 2
betaine-homocysteine methyltransferase 2
creatine kinase 2
polynucleotide kinase 2
cysteine synthase 2
caspase-7 2
dihydropyrimidine dehydrogenase 2
PDE 2
CDH 2
enolase 1
deoxycytidine deaminase 1
more...
Compound
DNA 3486
Dec 343
adenosylmethionine 202
methionine 174
lysine 169
5-Aza-2'-deoxycytidine 112
Clin 83
oxygen 76
Bisulfite 68
sodium 66
S-adenosylhomocysteine 64
MDA 58
cysteine 55
glucose 52
phosphate 48
5-Azacytidine 47
O6-Methylguanine 44
water 40
homocysteine 38
Cyt 38
arginine 36
zinc 36
DAC 36
hydrogen 34
retinoic acid 33
salt 33
ATP 29
calcium 27
sulfate 26
tyrosine 26
Temozolomide 26
alanine 25
BCNU 25
pyrimidine 25
pyrimidine 25
tryptophan 24
MTT 24
Histone 23
bis(2-chloroethyl) 23
bis(2-chloroethyl) 23
bis(2-chloroethyl) 23
serine 21
TNF 19
acetate 19
His 19
SDS 19
Adenine 18
TEM 18
DIM 18
MEK 17
bromide 17
leucine 17
DEAE 16
TET 16
TET 16
cAMP 15
ethanol 15
Asp 14
cadmium 14
GSH 14
GSH 14
nitric oxide 13
urea 13
iodine 13
iron 13
Mg2+ 13
tryptophan 12
pyrene 12
benzene 12
tryptophan 12
tryptophan 12
TNM 12
Phe 12
glutamine 11
Gly 11
SET 11
nitrogen 11
H2O2 10
galactose 10
Bisphenol A 10
nickel 10
glycerol 10
Bisphenol A 10
proline 10
copper 9
CPA 9
ammonium 9
selenium 9
PGA 9
DMSO 8
barium 8
vitamin D 8
phenol 8
glutamate 8
threonine 8
dUTP 8
ACS 8
NH2 8
methyl methanesulfonate 8
potassium 8
ACS 8
Epigallocatechin 8
Thyroid 7
ADP-ribose 7
TOF 7
Methionine 7
dCTP 7
hydroquinone 7
silver 7
nicotinamide 7
CBS 7
NAD 7
Optimal 7
formic acid 6
formic acid 6
formaldehyde 6
formaldehyde 6
formic acid 6
SAH 6
Curcumin 6
Homocysteine 6
anthracene 6
ADP 6
EDTA 6
Homocysteine 6
isocitrate 6
formic acid 6
ADP 6
ADP 6
DEHP 6
formic acid 6
EDTA 6
formic acid 6
formic acid 6
formic acid 6
formic acid 6
formic acid 6
boron 5
CAT 5
DBA 5
NMDA 5
acrylamide 5
asparagine 5
TCA 5
CAT 5
AAF 5
hydroxylamine 5
PMA 5
PGE 5
8-OHdG 5
Melatonin 5
Ile 5
CAT 5
ABL 5
Benzene 5
hydroxylamine 5
decarboxylated S-adenosylmethionine 5
PGE2 5
dCMP 5
H2S 5
more...