Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.1.1.37 (
DNA methyltransferase
)
4,983
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cellular RNAs with diverse chemical modifications have been observed, and N
6
-methyladenosine (m
6
A) is one of the most abundant internal modifications found on mRNA and non-coding RNAs, playing a vital role in diverse biologic processes. In humans, m
6
A modification is catalyzed by the METTL3-METTL14 methyltransferase complex, which is regulated by
WTAP
and another factor. Three groups have recently and independently reported the structure of this complex with or without cofactors. Here, we focus on the detailed mechanism of the m
6
A methyltransferase complex and the properties of each subunit. METTL3 is predominantly catalytic, with a function reminiscent of N
6
-adenine
DNA methyltransferase
systems, whereas METTL14 appears to be a pseudomethyltransferase that stabilizes METTL3 and contributes to target RNA recognition. The structural and biochemical characterization of the METTL3-METTL14 complex is a major step toward understanding the function of m
6
A modification and developing m
6
A-related therapies.
...
PMID:Human m
6
A writers: Two subunits, 2 roles. 2812 Dec 34
