Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.148 (Thy1)
 1,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fresh calf cancellous bone xenograft (FX), antigen free cancellous bone carrier (BC) and reconstituted bone xenograft (RBX) were inplanted in the thigh muscle pouches of Balb/c mice. Histological examinations were done at 7, 14 and 28 days postoperation, and indirect immunofluorescence was used to determine the positive counts of Thy1, L3T4, Lyt2, and Tac T lymphocyte of the blood and spleen at the same time, with the normal mouse lymphocytes as control. There was no significant difference between the BC implanted group and the normal (control) group, while the FX group had a significant increase rates of Thy1, L3T4 and Lyt2, especially of Tac lymphocytes. The RBX implanted group had no increase of Tac but increase of Thy1 and Lyt2. Th-Ts ratio decreased, and it was probably caused by bovine bone morphogenetic protein (bBMP) in the RBX. Histologically, intense immune rejection was noted in FX implanted group but not in the other two groups. Heterotopic ossification was noted in the RBX implanted group. FX increased intense immunologic rejection in the host, bat RBX did not, that might be due to the decrease of Th/Ts caused by bBMP. Tac lymphocyte count may indicate the immunologic rejection of bone xenograft transplantation.
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PMID:[Effect of bone xenograft transplantation on total T lymphocyte and its subset counts in mouse blood and spleen]. 959 87

Hereditary spastic paraplegias (HSPs) are characterized by progressive spasticity and weakness in the lower extremities that result from length-dependent central to peripheral axonal degeneration. Mutations in the non-imprinted Prader-Willi/Angelman syndrome locus 1 (NIPA1) transmembrane protein cause an autosomal dominant form of HSP (SPG6). Here, we report that transgenic (Tg) rats expressing a human NIPA1/SPG6 mutation in neurons (Thy1.2-hNIPA1) show marked early onset behavioral and electrophysiologic abnormalities. Detailed morphologic analyses reveal unique histopathologic findings, including the accumulation of tubulovesicular organelles with endosomal features that start at axonal and dendritic terminals, followed by multifocal vacuolar degeneration in both the CNS and peripheral nerves. In addition, the NIPA1 mutation in the spinal cord from older Tg rats results in an increase in bone morphogenetic protein type II receptor expression, suggesting that its degradation is impaired. This Thy1.2-hNIPA1 Tg rat model may serve as a valuable tool for understanding endosomal trafficking in the pathogenesis of a subgroup of HSP with an abnormal interaction with bone morphogenetic protein type II receptor, as well as for developing potential therapeutic strategies for diseases with axonal degeneration and similar pathogenetic mechanisms.
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PMID:Pathogenesis of autosomal dominant hereditary spastic paraplegia (SPG6) revealed by a rat model. 2412 79

Heterotopic ossification (HO), the formation of extra-skeletal bone in soft tissues, is a pathologic process occurring after substantial burns or trauma, or in patients with type I bone morphogenetic protein (BMP) receptor hyperactivating mutations. Identifying the cells responsible for de novo bone formation during adulthood is of critical importance for therapeutic and regenerative purposes. Using a model of trauma-induced HO with hind limb Achilles' tenotomy and dorsal burn injury and a genetic nontrauma HO model (Nfatc1-Cre/caAcvr1(fl/wt) ), we demonstrate enrichment of previously defined bone-cartilage-stromal progenitor cells (BCSP: AlphaV+/CD105+/Tie2-/CD45-/Thy1-/6C3-) at the site of HO formation when compared with marrow isolated from the ipsilateral hind limb, or from tissue of the contralateral, uninjured hind limb. Upon transplantation into tenotomy sites soon after injury, BCSPs isolated from neonatal mice or developing HO incorporate into the developing lesion in cartilage and bone and express chondrogenic and osteogenic transcription factors. Additionally, BCSPs isolated from developing HO similarly incorporate into new HO lesions upon transplantation. Finally, adventitial cells, but not pericytes, appear to play a supportive role in HO formation. Our findings indicate that BCSPs contribute to de novo bone formation during adulthood and may hold substantial regenerative potential. Stem Cells 2016;34:1692-1701.
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PMID:Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification. 2772 69