Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.1.1.148 (
Thy1
)
1,210
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A cell population from the central nervous system, of mainly astrocytes, was prepared and their susceptibility to
natural killer cell
lysis was compared to YAC-1 cells and L929 cells. Two populations of natural killer cells were used: the splenocytes of mice immunized with Semliki Forest virus 3 days previously and day 5 inflammatory cells from West Nile virus-infected CBA/H mouse brain. Both cell populations showed high lytic activity on YAC-1 cells and the effector cells possessed conventional
natural killer cell
markers, i.e.,
Thy1
+/-, L3T4-, Lyt2-, GM1+. The results revealed that astrocytes are not susceptible to lysis by natural killer cells and hence argue against the hypothesis that the absolute concentration of MHC antigens on the cell surface determines the susceptibility to
natural killer cell
lysis.
...
PMID:Astrocytes are not susceptible to lysis by natural killer cells. 339 4
