Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.1.1.148 (Thy1)
 1,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have characterized a population of large, brain-theta antigen-positive, secretory cells that occur in high frequency among murine bone marrow (approximately 6%), spleen (approximately 0.5%), and fetal liver (approximately 5%) cell populations. They do not occur in significant numbers among lymph node, thymus, and peritoneal exudate cells. These cells are Ly1, Ly2, and Thy1.2 negative, adherent to nylon wool, Sephadex G-10, and plastic, but peroxidase and Sudan black negative. They are radiation, cyclophosphamide, and cortisone resistant. These cells secrete a product of 30,000 to 40,000 m.w. of unknown function. Production of antisera specific for this molecule has facilitated identification of the cell by using a reverse hemolytic plaque-forming cell assay. Possible functions of this cell and its product are discussed.
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PMID:Identification of a brain theta-positive, secretory cell from hematopoietic tissues. 719 31

To identify genes expressed predominantly in the kidney with chronic and progressive glomerulosclerosis but not in acute and transient form of glomerulonephritis, we induced progressive glomerulosclerosis in rats by applying unilateral nephrectomy prior to injection of monoclonal anti-Thy1.1 antibody (OX-7), which cause acute and transient glomerulonephritis with single injection. In rats with nephrectomy and OX-7 injection (Nx group), proteinuria increased with time and mesangial expansion accompanied with interstitial fibrosis was recognized, whereas transient proteinuria and mesangiolysis followed by mesangial hypercellularity were seen in rats with sham operation and OX-7 injection (Sham group). Four weeks after the induction of glomerulonephritis, mRNAs were isolated from kidney cortex of both groups and used for cDNA synthesis. By subtraction hybridization of cDNAs from Nx with excess amount of those from Sham, we isolated and sequenced several genes expressed specifically in the Nx group. These included genes, which contain identical sequences with serine protease inhibitors, cytokine receptors, osteopontin as well as genes with unknown function. These genes may play important roles in the process which promotes acute glomerular damage advance to chronic and progressive glomerulosclerosis.
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PMID:Identification of genes specifically expressed in chronic and progressive glomerulosclerosis. 940 63

Although deoxythymidylate cannot be provided directly by ribonucleotide reductase, the gene encoding thymidylate synthase ThyA is absent from the genomes of a large number of nonsymbiotic microbes. We show that ThyX (Thy1) proteins of previously unknown function form a large and distinct class of thymidylate synthases. ThyX has a wide but sporadic phylogenetic distribution, almost exclusively limited to microbial genomes lacking thyA. ThyX and ThyA use different reductive mechanisms, because ThyX activity is dependent on reduced flavin nucleotides. Our findings reveal complexity in the evolution of thymidine in present-day DNA. Because ThyX proteins are found in many pathogenic microbes, they present a previously uncharacterized target for antimicrobial compounds.
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PMID:An alternative flavin-dependent mechanism for thymidylate synthesis. 1202 66