Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.1.1.148 (
Thy1
)
1,210
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The phenomenon that heme oxygenase-1 (HO-1) protects cell from injury yet its enzymatic product, iron, may facilitate generation of free radical has been long puzzling. Here we establish a functional connection between
ferritin heavy chain
(
FHC
) and HO-1. In human lupus nephritis HO-1 and
FHC
are colocalized within the glomeruli. In rodent anti-
Thy1
(thymocyte antigen 1) induced glomerulonephritis, heme oxygenase blockade lowers the expression of
FHC
and accelerates mesangial cell death. Stimulation of heme oxygenase in cultured rat mesangial cell enhances its resistance to hydrogen peroxide, whereas
FHC
knockdown by RNA interference compromises this salutary effect. RNA interference of HO-1 makes the cell more susceptible to hydrogen peroxide, which can be rescued by forced expression of wild-type
FHC
but not mutants that lose the capacity of iron storage and ferroxidase activity. Phosphorylation of JunD was not sustained in these cells. Microarray analysis identifies four candidate transcriptional factors that may regulate the HO-1-induced transcription of
FHC
. Our results support the role of
FHC
in neutralizing the iron toxicity as well as mediating the protective effect of HO-1 in response to oxidative stress.
...
PMID:Ferritin heavy chain mediates the protective effect of heme oxygenase-1 against oxidative stress. 2642 48
