Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.1.1.148 (
Thy1
)
1,210
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
THC
(delta-9-tetrahydrocannabinol), the major psychoactive component of marijuana, has been shown to suppress various immune functions in vivo and in vitro.
THC
suppresses murine T-lymphocyte proliferation; however, the effects on T-cell subsets remain unclear. We have stimulated cultured murine splenocytes with the mitogens concanavalin A (Con A) or phytohemagglutinin (PHA) while exposing them to varying concentrations of
THC
. After three days, the cells were analyzed by the fluorescent activated cell sorter for the following T-cell markers--
Thy1
, L3T4 and Ly2. The Ly2 cells represent the suppressor/effector T-cells while L3T4 cells represent the helper T-cell subpopulations. The results show that the dose response suppressive effect of
THC
on T-cell proliferation reflects a preferential inhibition of Ly2 vs L3T4 cells. The effects of
THC
on other functional parameters are in the process of investigation.
...
PMID:Differential suppression of T-cell subpopulations by thc (delta-9-tetrahydrocannabinol). 217 Feb 81
