Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.9.3.1 (cytochrome oxidase)
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Human Gene/Protein
CCDC56 11.8
COX7a-related protein 11.8
MMA-1 11.8
COX11 protein 11.8
ferrocytochrome c:oxygen oxidoreductase 11.8
C2orf64 11.8
MRPS14 11.8
COX7A2L protein 11.8
C1orf31 11.8
serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 11.8
C1orf163 11.8
mature T-cell proliferation 1 11.8
C20orf24 11.8
FASTKD5 11.2
cytochrome oxidase assembly factor 11.2
LSFC 11.0
cytochrome aa3 10.8
COX7B2 10.8
dehydrogenase/reductase member 3 10.8
HIGD2A 10.8
transmembrane 7 superfamily member 2 10.8
interferon regulatory factor 2 binding protein 1 10.8
EARS2 protein 10.8
G8 protein 10.8
AED 10.7
COX VIII-L 10.5
FAM36A 10.5
COX7A2L 10.4
COX18 10.4
SURF-1 10.3
Lon protease homolog 10.2
C2orf34 10.2
TIMM9 10.2
PET112 10.2
COI protein 10.2
mitochondrial ribosomal protein S11 10.2
cytochrome c oxidase subunit VIa polypeptide 1 10.2
COX16 10.1
SURF1 10.1
COX19 10.0
MTCO1 9.9
COX11 9.9
Hepatic leukemia factor 9.8
pyruvate carboxylase, mitochondrial 9.8
LACE1 9.8
cytochrome c oxidase assembly protein 9.8
COX7AL 9.8
troponin C2 9.8
SCAF1 9.8
COX10 9.7
GFM1 9.6
FASTKD2 9.6
COX4 9.6
COX17 9.5
Copper-transporting ATPase 9.5
FASTKD3 9.5
OXA1L 9.5
NADH-coenzyme Q reductase 9.5
COX IV 9.4
COX15 9.4
COX7A2 9.4
COX7RP 9.4
COX7A 9.3
COX5A 9.3
MRPL11 9.2
AFG3 9.2
COX6B2 9.2
COX6A 9.2
ZEC 9.2
HIG1 9.2
COXI 9.1
SCO1 9.1
COX8 9.1
NDUFB8 9.1
COXIII 9.1
MRPS22 9.0
Nucleoside diphosphokinase 9.0
spergen-1 9.0
CAMTA2 9.0
COX7B 9.0
more...
Disease
LSFC 11.0
Swayback 10.8
Gyrodactylosis 10.8
Disorders of mitochondrial metabolism 9.8
Wound myiasis 9.2
Complex III deficiency 9.0
Cytochrome c oxidase deficiency 8.8
Fecal peritonitis 8.4
Biventricular hypertrophy 8.4
COND 8.1
late onset disorder 8.1
ATP synthase deficiency 8.1
Leigh syndrome 7.8
MILS 7.7
Congenital fiber type disproportion 7.6
Complex I deficiency 7.5
CRD1 7.4
MERRF 7.4
NIID 7.3
Neonatal encephalopathy 7.3
EBS2 7.2
MNGIE 7.2
Alpers 7.1
mitochondrial disease 7.1
Mitochondrial DNA depletion 7.1
Cocaine use disorder 7.1
Chronic hyponatremia 7.1
mitochondrial myopathy 7.0
Copper deficiency 6.9
endophlebitis 6.9
PDH deficiency 6.9
RCA1 6.9
arbovirus disease 6.9
EBS1 6.8
MELAS 6.7
sulfhemoglobinemia 6.7
Zoonotic cutaneous leishmaniasis 6.7
MELAS 6.6
disorders of amino acid metabolism 6.6
Kearns-Sayre syndrome 6.4
mitochondrial encephalomyopathy 6.4
OPA1 6.3
encephalomyelopathy 6.2
disorders of copper metabolism 6.2
MDS/MPD 6.2
Menkes 6.2
Diabetic encephalopathy 6.1
Pearson's syndrome 6.1
Chronic progressive external ophthalmoplegia 6.0
Balo's concentric sclerosis 6.0
Gerhardt 6.0
lactic acidosis 6.0
Central core disease 5.8
perinephritis 5.8
Richner-Hanhart syndrome 5.7
Lepromatous leprosy 5.6
Bergeron 5.6
Cerebral hypoperfusion 5.6
ANM 5.6
rat-bite fever 5.6
hepatic echinococcosis 5.5
Brazilian spotted fever 5.5
FRDA 5.5
SPG7 5.5
hyperargininemia 5.5
swimmer's itch 5.4
ectoparasitism 5.4
Keshan disease 5.4
Echinococcus granulosus infection 5.4
Fuchs' endothelial dystrophy 5.3
leukodystrophy 5.3
hyperprolinemia 5.3
coenurosis 5.2
CMD 5.2
chondrodystrophy 5.2
CMD 5.2
SVD 5.2
PMD 5.2
Acute mountain sickness 5.1
cardiac overload 5.1
more...
Symptom
Angioscotoma 11.8
restriction of respiration 9.8
Drugged 7.9
Exercise intolerance 6.6
Reticulocytosis 6.2
dysosmia 5.3
hypotonia 5.1
hangover 4.9
Decreased activity 4.8
ophthalmoplegia 4.8
Excitability 4.5
Deafferentation 4.4
Extrapyramidal symptoms 4.2
giddiness 4.2
giddiness 4.2
labored breathing 4.1
hyperoxia 3.8
male subfertility 3.8
Anoxia 3.7
urethral discharge 3.6
autodigestion 3.5
prostration 3.3
hepatomegaly 3.0
ataxia 3.0
neurological disability 3.0
chorea 2.8
ketonuria 2.7
breath holding 2.7
cerebellar ataxia 2.6
Mills 2.5
exhaustion 2.4
lethargy 2.3
memory loss 2.3
clonus 2.3
weakness 2.2
torticollis 2.2
incoordination 2.0
paraparesis 2.0
DNA marker 2.0
dystonia 1.9
dysarthria 1.9
eds 1.8
Hudson 1.8
myoclonus 1.8
myalgia 1.7
functional recovery 1.7
cachexia 1.7
abnormal gait 1.7
seizures 1.6
collapse 1.5
hypertonia 1.5
cyanosis 1.5
pallor 1.5
tachypnea 1.5
fasciculation 1.5
Wind 1.5
anosmia 1.2
physical appearance 1.2
photophobia 1.2
despair 1.2
hypocapnia 1.1
starvation 1.0
hypothermia 0.9
paresis 0.9
hypercapnia 0.9
Depressive symptoms 0.9
twitching 0.8
apathy 0.8
spasticity 0.7
acute stress 0.6
fatigue 0.6
vomiting 0.6
masculinization 0.5
tremor 0.5
asthenia 0.4
thinning 0.4
polyuria 0.2
respiratory distress 0.1
anesthesia 0.1
constipation 0.1
more...
Drug
Haloperidol Decanoate 9.2
Duroquinone 8.2
Atabrine 7.9
Ferumoxides 7.2
Sodium Nitroprusside 7.2
Naftidrofuryl 6.6
URF 6.3
NADH 6.2
Sodium ascorbate 6.1
Epidoxorubicin 6.0
Folic Acid 5.8
Senna 5.6
3,4-Dihydroxyphenylalanine 5.5
Senna 5.5
Fusicoccin 5.4
7-Nitroindazole 5.4
Zinc sulfate 5.3
Zinc sulfate 5.3
Sodium thiosulfate 5.2
Singular 5.2
Heme 5.1
Cytidine 5.0
Protamine sulfate 4.9
Hyperforin 4.8
Reserpine 4.7
Methylene blue 4.7
ascorbate 4.5
Fenbendazole 4.5
Lead acetate 4.5
Flavin 4.4
Retinoic Acid 4.3
Tween 40 4.2
Digenea 4.1
FAD 4.1
Trifluoperazine 4.0
Papaverine 3.9
Thioridazine 3.9
Photofrin II 3.8
NBT 3.8
Cobalamin 3.8
Bezafibrate 3.7
ROS 3.6
AZT 3.6
Sumatran 3.5
Fipronil 3.5
Mirtazapine 3.5
Perindopril 3.5
Isotretinoin 3.4
AZT 3.4
Codeine 3.4
Galactose 3.4
Caspofungin 3.4
Fulvestrant 3.4
Codeine 3.3
SMP 3.2
Cantor 3.2
Riboflavin 3.2
Lugol 3.2
Doyle 3.2
CTT 3.1
LCM 3.0
LCM 3.0
ddI 3.0
MEA 3.0
Adenosine triphosphate 3.0
Vitamin K 2.9
Viagra 2.9
ISP 2.9
Emodin 2.9
citric acid 2.9
EHDP 2.9
Acacia 2.7
Doxycycline 2.7
Clofibrate 2.7
Emodin 2.6
Viagra 2.6
PPA 2.6
Helium 2.6
PCP 2.5
Parkin 2.5
more...
Enzyme
cytochrome oxidase 11.8
EC 2.1.1.16 10.2
farnesol dehydrogenase 9.8
ubiquinol-cytochrome c oxidoreductase 9.3
glucoside 3-dehydrogenase 8.4
hydroxylamine oxidase 8.2
succinate dehydrogenase 8.1
complex I 8.1
succinic dehydrogenase 7.8
citrate synthase 7.8
D-cysteine desulfhydrase 7.8
NADH dehydrogenase 7.8
diaphorase 7.7
beta-hydroxybutyrate dehydrogenase 7.6
hypodermin C 7.2
glyoxylate reductase 7.1
LTB4 omega-hydroxylase 7.1
glyoxylate reductase 7.1
CPR 7.1
thiosulfate dehydrogenase 7.1
beta-glycerophosphatase 7.1
i-AAA protease 7.0
glycolate dehydrogenase 7.0
2-oxoglutarate decarboxylase 6.9
hydroxylamine reductase 6.8
hydroxylamine reductase 6.8
nitrous oxide reductase 6.7
acyl-CoA reductase 6.7
2-hydroxyglutarate dehydrogenase 6.7
3-hydroxyacyl-CoA dehydrogenase 6.6
cytochrome c peroxidase 6.5
ATP synthase 6.5
3-hydroxy-3-methylglutaryl-CoA lyase 6.5
acetylornithine aminotransferase 6.5
malate dehydrogenase 6.5
glycine dehydrogenase 6.5
DHOdehase 6.4
aconitase 6.3
3-hydroxyacyl-CoA dehydrogenase 6.3
p-cresol methylhydroxylase 6.3
m-AAA protease 6.3
alpha-ketoglutarate dehydrogenase 6.3
3-oxoacid CoA-transferase 6.2
SAICAR synthetase 6.2
AFR 6.2
glycolate oxidase 6.1
glycerol-3-phosphate oxidase 6.1
fumarase 6.1
electron transfer flavoprotein dehydrogenase 6.1
methylamine dehydrogenase 6.1
DAP II 6.0
iodothyronine 5'-deiodinase 6.0
alpha-L-rhamnosidase 6.0
hydroxypyruvate reductase 6.0
N-acetylglutamate kinase 5.9
isocitrate dehydrogenase 5.9
isopropylmalate isomerase 5.9
NADPH-diaphorase 5.9
arginine kinase 5.9
carbamoylphosphate synthetase 5.9
glycerol-3-phosphate dehydrogenase 5.9
triose-phosphate isomerase 5.8
glycerol-3-phosphate dehydrogenase 5.8
nitrite reductase 5.8
nitrite reductase 5.8
nucleoside triphosphate phosphohydrolase 5.8
hydroxypyruvate reductase 5.8
nitrite reductase 5.8
phosphofructokinase 5.8
rhodanese 5.7
isocitrate dehydrogenase 5.7
PDH 5.7
glutamate dehydrogenase 5.7
glutamate dehydrogenase 5.7
pyruvate dehydrogenase 5.7
SirA 5.7
pyruvate dehydrogenase 5.7
glutamate dehydrogenase 5.7
exonuclease VII 5.6
glutamic dehydrogenase 5.6
more...
Compound
Diaminomaleonitrile 11.8
C33H54O4 11.8
Cue-lure 11.8
C33H54O4 11.8
Ubisemiquinone 10.8
4-hydroxy-4-(3-pyridyl)-butanoic acid 10.2
sebacamide 9.8
4'-Epiadriamycin 9.8
Durohydroquinone 9.5
C33H54O4 9.5
Cytochrome c1 9.3
TMPD 9.3
Rapanone 9.2
2-Bromohydroquinone 9.2
heme O 9.1
C5H6O4 8.8
o-Iodosobenzoate 8.8
2-methyl-3-hydroxybutyryl-CoA 8.8
Heliotrine 8.8
Pyrrolnitrin 8.8
Heliotrine 8.6
heptanamide 8.6
Cobinamide 8.6
C5H6O4 8.5
Menadiol 8.5
Diiodothyronine 8.2
10-formyldihydrofolate 8.2
Cytochrome c 8.1
3-succinoylpyridine 8.0
2,2',5,5'-TCB 7.9
propyl carbamate 7.8
Duroquinone 7.7
Salicylaldoxime 7.7
3-T1 7.6
Dehydrocostus lactone 7.6
Isovitexin 7.5
ubiquinol 7.5
3,5-T2 7.4
COX 7.1
R207910 7.1
Octyl gallate 7.1
Hoechst dye 33258 7.1
MoS4 7.0
Cuprizone 6.9
2-chlorobenzoic acid 6.9
Sodium azide 6.9
TPTA 6.8
DHCA 6.7
cyanide 6.6
COI 6.6
Malonate 6.6
mercaptopyruvate 6.4
Blue Tetrazolium 6.4
Rotenone 6.4
3-Hydroxykynurenine 6.4
2-ethylhexanoic acid 6.3
2-ethylhexanoic acid 6.3
Hydroxypyruvate 6.3
2,6-dimethylmorpholine 6.3
2-ethylhexanoic acid 6.3
reduced riboflavin 6.3
Hydroxocobalamin 6.3
Clorgyline 6.2
NADH 6.2
Amytal 6.1
Erucic acid 6.1
2-methoxybenzoic acid 6.1
S-sulfocysteine 6.1
alpha-isopropylmalate 6.1
Pimonidazole 6.0
Pimonidazole 6.0
Antimycin 6.0
ubiquinone 6.0
Cyt 6.0
Quisqualic acid 6.0
Dibucaine 5.9
Valinomycin 5.9
2-ethylhexanoic acid 5.9
Psychosine 5.9
Liquiritigenin 5.8
more...