Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.9.3.1 (cytochrome oxidase)
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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
cytochrome 866
cytochrome aa3 865
cytochrome c oxidase 816
Mol 759
cytochrome c 746
ATP 627
Sep 574
AED 423
NADH 422
cytochrome b 311
citrate synthase 274
ATPase 265
catalase 194
ADP 187
lactate dehydrogenase 184
superoxide dismutase 179
hemoglobin 161
Cytochrome c 149
peroxidase 137
ATP synthase 136
reductase 135
NADH dehydrogenase 127
cryptic 126
COX 122
NAD 119
tRNA 116
polypeptide 111
ubiquinone 109
COI 105
nitric oxide synthase 105
acid phosphatase 100
oxidoreductase 99
acetylcholinesterase 98
malate dehydrogenase 97
EPR 97
insulin 93
membrane-bound 90
axonal 78
NADPH 75
Pseudomonas 75
complex I) 74
membrane protein 73
myoglobin 71
Gen 67
ROS 66
creatine kinase 66
parvalbumin 66
alkaline phosphatase 66
endoplasmic reticulum 65
microsomal 64
glutamate dehydrogenase 63
GSH 61
esterase 58
nov 57
phosphofructokinase 56
CO2 54
hexokinase 54
caspase-3 53
PGC 53
glucose-6-phosphate dehydrogenase 52
fused 49
pyruvate dehydrogenase 49
COII 49
calbindin 49
isocitrate dehydrogenase 48
pyruvate kinase 47
COX1 47
cox1 47
ferrocytochrome c:oxygen oxidoreductase 44
SDS 43
acyl-CoA oxidase 42
glutathione peroxidase 41
dimeric 40
proton pump 40
GABA 39
peroxisome proliferator-activated receptor 39
glucose-6-phosphatase 38
aconitase 37
uncoupling protein 37
AMP 36
more...
Disease
Alzheimer's disease 154
ischemia 143
cold 103
Parkinson's disease 100
cancer 98
Leigh syndrome 92
depression 81
myopathy 72
lactic acidosis 72
mitochondrial disease 70
tumor 69
diabetes 64
GSH 61
stroke 58
cardiomyopathy 53
encephalopathy 46
obesity 43
SDS 43
mitochondrial myopathy 39
epilepsy 38
West 36
Huntington's disease 35
malaria 34
amyotrophic lateral sclerosis 29
hypertension 29
heart failure 29
neuroblastoma 28
sepsis 28
worms 28
hepatocellular carcinoma 27
mole 27
mole 27
dementia 26
sepsis 26
developmental delay 25
cerebral ischemia 24
neuropathy 23
Menkes 21
failure to thrive 20
SEM 20
anemia 20
pheochromocytoma 19
multiple sclerosis 19
IVA 18
hypertrophic cardiomyopathy 18
hypothyroidism 18
Brown 18
cognitive impairment 18
fits 18
PCC 17
schizophrenia 16
MELAS 16
NAME 16
iron deficiency 16
cholera 16
hyperglycemia 16
OPA1 15
type 2 diabetes 15
Kearns-Sayre syndrome 15
Echinococcus 15
HIV 14
optic atrophy 14
myocardial ischemia 14
MELAS 14
carcinoma 14
respiratory failure 14
strabismus 13
myocardial infarction 12
coma 12
cirrhosis 12
lice 12
mitochondrial encephalomyopathy 12
malnutrition 12
cataract 12
peripheral neuropathy 12
cardiovascular disease 11
confusion 11
hypoglycemia 11
deafness 11
Copper deficiency 11
more...
Symptom
seizures 67
hypotonia 57
weakness 47
ataxia 35
anesthesia 33
ophthalmoplegia 25
collapse 23
fatigue 22
exhaustion 20
hyperoxia 20
starvation 14
hepatomegaly 13
vomiting 13
functional recovery 12
pain 12
dystonia 9
hypothermia 9
lethargy 8
tremor 7
cerebellar ataxia 6
myalgia 6
respiratory distress 6
cachexia 5
dyspnea 5
memory loss 5
diarrhea 5
headache 5
dysarthria 4
myoclonus 4
thinning 4
hypercapnia 4
nausea 4
chorea 4
Decreased activity 4
constipation 3
cyanosis 3
paresis 3
spasticity 3
hangover 3
paraparesis 3
stigma 3
Exercise intolerance 3
anorexia 3
Anoxia 2
torticollis 2
sleepiness 2
dizziness 2
Excitability 2
tachypnea 2
acute stress 2
incoordination 2
splenomegaly 2
agitation 2
neurological disability 2
apathy 2
angina 2
Mills 2
Wind 2
pallor 2
cough 1
ketonuria 1
restriction of respiration 1
DNA marker 1
despair 1
polyuria 1
asthenia 1
Ill 1
regurgitation 1
dysosmia 1
insomnia 1
fasciculation 1
acidity 1
erythema 1
Drugged 1
vertigo 1
masculinization 1
male subfertility 1
Reticulocytosis 1
autodigestion 1
spasm 1
more...
Drug
NADH 434
ascorbate 149
lysine 67
ROS 66
Heme 30
FAD 26
citric acid 20
vitamin E 19
Gel 17
CSF 14
Cardiovasc 13
Ethanol 10
AZT 9
AZT 9
Methylene blue 9
Leaf 9
Nephron 8
lactose 8
caffeine 8
Reserpine 7
Dermatol 7
Glutathione 6
Asn 6
NH3 6
PCP 6
Singular 5
NBT 5
Kenyan 5
Adriamycin 5
ALA 4
ampicillin 4
ICI 4
ABC 4
Atabrine 4
Senna 4
Vitamin A 4
Senna 4
CTX 3
p75 3
Galactose 3
DHT 3
Indomethacin 3
Monit 3
Parkin 3
DNase I 3
Propofol 3
Acacia 3
Digenea 3
Nitric Oxide 3
Vitamin K 3
pyridoxal phosphate 3
Fragment 3
DHT 3
THF 3
Glucagon 3
niacin 3
Retinoic acid 3
Parkin 3
Trifluoperazine 2
EE2 2
Fructose 2
Vitamin E 2
MAP 2
Naftidrofuryl 2
Vitamin B12 2
Simvastatin 2
Doxycycline 2
CaCl2 2
Alanine 2
Portal 2
Papaverine 2
ETA 2
CaCl2 2
CaCl2 2
Cytidine 2
Frontal 2
Riboflavin 2
URF 2
Retinoic Acid 2
CDP 2
more...
Enzyme
cytochrome oxidase 8822
complex I 696
succinate dehydrogenase 640
ATPase 379
diaphorase 340
citrate synthase 281
superoxide dismutase 204
catalase 201
lactate dehydrogenase 199
CPR 195
ATP synthase 181
peroxidase 163
NADH dehydrogenase 128
malate dehydrogenase 114
succinic dehydrogenase 110
acetylcholinesterase 104
acid phosphatase 100
creatine kinase 74
monoamine oxidase 72
NO synthase 70
alkaline phosphatase 66
glutamate dehydrogenase 64
glutamate dehydrogenase 64
NADPH-diaphorase 63
pyruvate dehydrogenase 62
glutamate dehydrogenase 62
glucose-6-phosphate dehydrogenase 58
phosphofructokinase 58
hexokinase 54
isocitrate dehydrogenase 52
pyruvate dehydrogenase 51
isocitrate dehydrogenase 51
pyruvate dehydrogenase 49
NQO1 47
pyruvate kinase 47
caspase-3 43
glutathione peroxidase 42
ceruloplasmin 40
aconitase 39
phosphorylase 39
glucose-6-phosphatase 38
diaphorase 36
aspartate aminotransferase 35
nitrite reductase 30
nitrite reductase 29
nitrite reductase 29
ubiquinol-cytochrome c oxidoreductase 29
glycerol-3-phosphate dehydrogenase 29
glycerol-3-phosphate dehydrogenase 28
alpha-ketoglutarate dehydrogenase 27
AMP-activated protein kinase 26
protein kinase 25
beta-glucuronidase 23
5'-nucleotidase 22
glutathione reductase 21
fumarase 21
cholinesterase 21
alanine aminotransferase 20
glyceraldehyde-3-phosphate dehydrogenase 20
beta-hydroxybutyrate dehydrogenase 20
CPT 20
dihydrofolate reductase 18
xanthine oxidase 18
3-hydroxyacyl-CoA dehydrogenase 18
tyrosine hydroxylase 18
cytochrome c peroxidase 18
beta-galactosidase 17
glutathione S-transferase 17
glyceraldehyde-3-phosphate dehydrogenase 17
mitogen-activated protein kinase 17
choline acetyltransferase 16
glyceraldehyde-3-phosphate dehydrogenase 16
NOS 16
reverse transcriptase 15
3-hydroxyacyl-CoA dehydrogenase 15
alcohol dehydrogenase 15
NADPH oxidase 15
glyceraldehyde-3-phosphate dehydrogenase 15
nitrate reductase 14
NADPH oxidase 14
more...
Compound
oxygen 1422
DNA 1372
ATP 629
Dec 627
cyanide 460
NADH 433
copper 416
glucose 330
water 330
sodium 265
iron 254
nitric oxide 241
calcium 240
ADP 201
CO2 200
phosphate 191
ADP 188
ADP 188
hydrogen 178
glutamate 172
NAD 152
Cytochrome c 149
COX 122
NAD 119
nitrogen 115
Clin 110
ubiquinone 107
COI 107
potassium 98
nicotinamide 93
His 91
H2O2 90
ethanol 89
ubiquinol 85
leucine 80
lysine 80
NADPH 75
NADPH 75
cysteine 72
zinc 72
sulfate 71
GSH 70
GSH 70
methionine 69
arginine 69
Cereb 64
nitrate 62
acetate 60
galactose 57
salt 54
SDS 53
tyrosine 53
Cyt 53
H2S 52
Triton X-100 51
succinic acid 50
alanine 46
bromide 43
ammonium 42
glycerol 41
CoA 40
tryptophan 40
tryptophan 40
GABA 40
tryptophan 39
tryptophan 39
GABA 39
AMP 38
TMPD 37
H2S 37
NADP 36
urea 35
GDP 35
phosphocreatine 34
manganese 32
Heme 31
proline 31
serine 30
2-oxoglutarate 29
Mg2+ 27
more...