Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.9.3.1 (cytochrome oxidase)
 8,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the primary visual area of macaques and other monkeys, layer 4A is a mosaic of separate tissue compartments related to the parvocellular (P) and magnocellular (M) layers of the lateral geniculate nucleus. This mosaic resembles a honeycomb, with thin walls that receive direct P inputs and cores consisting of columns of dendrites and cell bodies ascending from layer 4B, a layer that receives indirect M inputs. To determine whether apes and humans have a macaque-like layer 4A, we examined the primary visual area in humans, chimpanzees, an orangutan, Old World monkeys, and New World monkeys. Apes and humans lacked the dense band of cytochrome oxidase staining in layer 4A that marks the stratum of P-geniculate afferents in monkeys. Furthermore, humans displayed a unique arrangement of presumed M-related cells and dendrites in layer 4A, as revealed with antibodies against nonphosphorylated neurofilaments and microtubule-associated protein 2. Human 4A contained a large amount of M-like tissue distributed in a complex, mesh-like pattern rather than in simple vertical arrays as in other anthropoid primates. Our results suggest that (i) the direct P-geniculate projection to layer 4A was reduced early in the evolution of the ape-human group, (ii) the M component of layer 4A was subsequently modified (and possibly enhanced) in the human lineage, and (iii) the honeycomb model does not adequately characterize human layer 4A. This is the first demonstration of a difference in the cortical architecture of humans and apes, the animals most closely related to humans.
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PMID:Distinctive compartmental organization of human primary visual cortex. 1050 Feb 23

Pinnipeds (sea lions, seals, and walruses) are notable for many reasons, including their ape-sized brains, their adaptation to a coastal niche that combines mastery of the sea with strong ties to land, and the remarkable abilities of their trigeminal whisker system. However, little is known about the central nervous system of pinnipeds. Here we report on the somatosensory areas of the nervous system of the California sea lion (Zalophus californianus). Using stains for Nissl, cytochrome oxidase, and vesicular glutamate transporters, we investigated the primary somatosensory areas in the brainstem, thalamus, and cortex in one sea lion pup and the external anatomy of the brain in a second pup. We find that the sea lion's impressive array of whiskers is matched by a large trigeminal representation in the brainstem with well-defined parcellation that resembles the barrelettes found in rodents but scaled upward in size. The dorsal column nuclei are large and distinct. The ventral posterior nucleus of the thalamus has divisions, with a large area for the presumptive head representation. Primary somatosensory cortex is located in the neocortex just anterior to the main vertical fissure, and precisely locating it as we do here is useful for comparing the highly gyrified pinniped cortex with that of other carnivores. To our knowledge this work is the first comprehensive report on the central nervous system areas for any sensory system in a pinniped. The results may be useful both in the veterinary setting and for comparative studies related to brain evolution.
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PMID:Somatosensory brainstem, thalamus, and cortex of the California sea lion (Zalophus californianus). 2687 87

The northern elephant seal (Mirounga angustirostris) and California sea lion (Zalophus californianus) are members of a diverse clade of carnivorous mammals known as pinnipeds. Pinnipeds are notable for their large, ape-sized brains, yet little is known about their central nervous system. Both the northern elephant seal and California sea lion spend most of their lives at sea, but each also spends time on land to breed and give birth. These unique coastal niches may be reflected in specific evolutionary adaptations to their sensory systems. Here, we report on components of the visual pathway in these two species. We found evidence for two classes of myelinated fibers within the pinniped optic nerve, those with thick myelin sheaths (elephant seal: 9%, sea lion: 7%) and thin myelin sheaths (elephant seal: 91%, sea lion: 93%). In order to investigate the architecture of the lateral geniculate nucleus, superior colliculus, and primary visual cortex, we processed brain sections from seal and sea lion pups for Nissl substance, cytochrome oxidase, and vesicular glutamate transporters. As in other carnivores, the dorsal lateral geniculate nucleus consisted of three main layers, A, A1, and C, while each superior colliculus similarly consisted of seven distinct layers. The sea lion visual cortex is located at the posterior side of cortex between the upper and lower banks of the postlateral sulcus, while the elephant seal visual cortex extends far more anteriorly along the dorsal surface and medial wall. These results are relevant to comparative studies related to the evolution of large brains.
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PMID:Optic nerve, superior colliculus, visual thalamus, and primary visual cortex of the northern elephant seal (Mirounga angustirostris) and California sea lion (Zalophus californianus). 2818 22