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Query: EC:1.9.3.1 (
cytochrome oxidase
)
8,822
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The operon coding for a respiratory quinol oxidase was cloned from thermoacidophilic archaebacterium Sulfolobus acidocaldarius. It contains three genes, soxA,
soxB
and soxC. The first two genes code for proteins related to the cytochrome c oxidase subunits II and I, respectively. soxC encodes a protein homologous to cytochrome b, which is a subunit of the mitochondrial and bacterial cytochrome c reductases and the chloroplast cytochrome b6f complex. soxA is preceded by a promoter and the genes are cotranscribed into a 4 kb mRNA. Their protein products form a complex which has been partially purified and has quinol oxidase activity. The reduced minus oxidized absorption spectrum of the complex has two maxima at 586 and 606 nm. The latter is typical of cytochrome c oxidase. The complex contains four haems A. Two haems belong to the '
cytochrome oxidase
' part of the complex and two are probably bound to be apocytochrome b (SoxC) and responsible for the 586 nm absorption peak. The homology between the sox gene products and their mitochondrial counterparts suggests that energy conservation coupled to the quinol oxidation catalysed either by the Sulfolobus oxidase or two mitochondrial respiratory enzymes may have a similar mechanism.
...
PMID:An archaebacterial terminal oxidase combines core structures of two mitochondrial respiratory complexes. 137 50
Thermithiobacillus tepidarius
DSM 3134
T
was originally isolated (1983) from the waters of a sulfidic spring entering the Roman Baths (Temple of Sulis-Minerva) at Bath, United Kingdom and is an obligate chemolithoautotroph growing at the expense of reduced sulfur species. This strain has a genome size of 2,958,498 bp. Here we report the genome sequence, annotation and characteristics. The genome comprises 2,902 protein coding and 66 RNA coding genes. Genes responsible for the transaldolase variant of the Calvin-Benson-Bassham cycle were identified along with a biosynthetic horseshoe
in lieu
of Krebs' cycle
sensu stricto
. Terminal oxidases were identified,
viz.
cytochrome
c
oxidase (
cbb
3
,
EC 1.9.3.1
) and ubiquinol oxidase (
bd
, EC 1.10.3.10). Metalloresistance genes involved in pathways of arsenic and cadmium resistance were found. Evidence of horizontal gene transfer accounting for 5.9 % of the protein-coding genes was found, including transfer from
Thiobacillus
spp. and
Methylococcus capsulatus
Bath, isolated from the same spring. A
sox
gene cluster was found, similar in structure to those from other
Acidithiobacillia
- by comparison with
Thiobacillus thioparus
and
Paracoccus denitrificans
, an additional gene between
soxA
and
soxB
was found, annotated as a DUF302-family protein of unknown function. As the Kelly-Friedrich pathway of thiosulfate oxidation (encoded by
sox
) is not used in
Thermithiobacillus
spp., the role of the operon (if any) in this species remains unknown. We speculate that DUF302 and
sox
genes may have a role in periplasmic trithionate oxidation.
...
PMID:Permanent draft genome of
Thermithiobaclillus tepidarius
DSM 3134
T
, a moderately thermophilic, obligately chemolithoautotrophic member of the
Acidithiobacillia
. 2777 47
