Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.9.3.1 (cytochrome oxidase)
 8,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunostimulants are widely used in aquaculture, but there are few reports on the genes that are expressed by their stimulation. Therefore, in this study, expressed genes in the kidney of Japanese flounder Paralichthys olivaceus injected with the immunostimulant peptidoglycan were analysed. The results of single-pass sequencing of ESTs from 198 clones (AU090255-AU090451, AU090935) from kidney cDNA are presented. Sequences of the cDNA clones were compared with sequences in the GenBank database. One hundred and six clones (53.5%) appeared to be completely unknown and are likely to represent newly described genes, whereas 92 clones (46.5%) were identified based on matches to sequences in the database. The results contain the genes such as alpha globin (AU090287), several ribosomal proteins (AU090-263, 274, 299, 351, 365, 375, 377, 382, 434, 445), heat shock protein 90 (AU090374) and cytochrome oxidase subunit (AU090385). Immune related cDNAs identified from the kidney were immunoglobulin heavy (AU090291) and light chain (AU090352), beta2-microglobulin (AU090280), macrophage inflammatory protein 1-alpha precursor (AU090535), thymosin beta-10 (AU090391), lysozyme (AU090322) and MHC class IIalpha (AU090435). It is possible that expression of macrophage inflammatory protein 1-alpha results in macrophage activation as a consequence of peptidoglycan treatment.
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PMID:The analysis of expressed genes in the kidney of Japanese flounder, Paralichthys olivaceus, injected with the immunostimulant peptidoglycan. 1141 22