Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.9.3.1 (cytochrome oxidase)
 8,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study of the participation of metals in evolution of oxidation-reduction processes is subdivided into two periods. During the first of them, from 1897 to 1937, the significance of manganese, iron, titanium, molybdenum, vanadium and copper in most important processes of metabolism was discovered. The second period, from 1937 to 1977, was devoted to the study of the role of metals in individual representatives of oxidoreductases and their evolution during transition of organisms from anaerobiosis to aerobiosis. In this evolution of special importance were bimetallic enzymes, such as nitrogenase, some nitrate reductases and hydrogenases, carbon dioxide reductase, xanthine oxidase, cytochrome oxidase. Owing to their ability to accomplish conjugated oxidation-reduction reactions, these oxidoreductases were transitional to still more complicated polymetallic systems with whose participation the electron transfer chains in subcellular structures were formed.
 ...
PMID:[Participation of polyvalent metals in the evolution of oxidoreductases]. 91 1

Changes in selected enzyme parameters were followed in a one year-long toxicologic experiment on albino rat males given vanadium by mouth at either of two dosages: 0.005 mg/kg b.w., which is the equivalent of the regulated level for 1st category drinking water, or 0.01 mg/kg, i.e., twice the safety standard. The endpoints measured included: free sulfhydryl groups in blood serum, heart, and liver; cholinesterase and creatine kinase activities in blood serum; catalase activity in blood; and cytochrome oxidase activity in liver and heart. Chronic oral exposures to vanadium 0.01 mg/kg and, to a lesser extent, 0.005 mg/kg were observed to produce disturbances in redox processes and tissue respiration. The evidence from this study should be taken into consideration when regulating vanadium levels in drinking water from a hygiene standpoint.
 ...
PMID:[An experimental study of the effect of vanadium on enzyme indices in chronic oral exposure]. 852 48