Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.9.3.1 (
cytochrome oxidase
)
8,822
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The mitochondrial protein content of liver increased, and mitochondria enlarged after prolonged administration of valproic acid (VPA:
N-dipropylacetic acid
) to rats. The mitochondria showed low specific activities of membrane-bound enzymes, decreased content of
cytochrome aa3
, and decreased respiration in states 3 and 4. In vitro studies of amino acid incorporation suggested a decrease in protein synthesis in liver mitochondria from VPA-treated rats. Prolonged administration of VPA seems to impair mitochondrial structure and function.
...
PMID:Effects of valproate on biogenesis and function of liver mitochondria. 300 16
