Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.9.3.1 (cytochrome oxidase)
 8,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study documents the effects of an intracarotid artery injection of a lethal threshold amount of KCN (2.5 mg.kg-1) on the energy metabolism and histology of the rat brain. This dose of KCN resulted in a rapid abolition of electroencephalographic activity, which remained essentially absent for up to 3 h. Cerebral metabolite measurements 0.25 h after KCN infusion indicated a 52% reduction in cytochrome oxidase activity, a 600% increase in lactate, a 32% reduction in ATP, a 73% increase in ADP, and an 85% decrease in glycogen. Measurements of the above energy metabolites over the ensuing 7 days showed a return to control of all metabolites by 6-24 h. Corresponding to the normalization of energy metabolism was a return of EEG and conscious activity. Histological examination of cyanide-exposed animals revealed a paucity of change with only one animal at 0.5 h showing several dark neurons, two animals at 1 h with minor pallor of corpus callosum and caudate-putamen, and one animal at 48 h with a small hippocampal infarction. It is concluded that it may be impossible to produce a serious enough disruption of cerebral metabolism with KCN injection, to produce neuronal damage by purely "histotoxic" mechanisms.
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PMID:Cerebral energy metabolism in cyanide encephalopathy. 292 Dec 90

Recent evidence points to the existence of lattices of acetylcholinesterase (AChE) and cytochrome oxidase (CYO) in deep layers of the superior colliculus. We sought to further describe their localization within the rat superior colliculus using new three dimensional (3D) digital imaging techniques. Texture maps of AChE staining within the stratum griseum intermediate (SGI) suggest a sheet of high enzyme activity punctuated by areas of pallor. This lattice of dense staining covered the caudal end of the colliculus and extended rostrally along the medial bank. Discrete regions of low staining were most apparent within the IVc subdivision of SGI. A similar examination of CYO activity failed to reveal any compartmentalization.
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PMID:3D spatial relationships of histochemical activity in the rat superior colliculus. 771 Aug 12