Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.9.3.1 (
cytochrome oxidase
)
8,822
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The gene for subunit II of
cytochrome oxidase
is part of the mitochondrial genome. 17 beta-Estradiol, 1 nM, increased the levels of
cytochrome oxidase
II mRNA in the GH4C1
pituitary tumor
cell line; the increases ranged from 3- to 16-fold over controls in different experiments. Insulin, 300 nM, estradiol, 1 nM, and epidermal growth factor, 10 nM, together caused a larger increase in
cytochrome oxidase
II mRNA accumulation than did estradiol alone. The dose-response relationship for the induction of
cytochrome oxidase
II mRNA by estradiol was similar to that for PRL mRNA; maximal induction occurred at about 10(-9) M. This concentration is 10-fold greater than that required for maximal stimulation of cell proliferation and of 1C28, another estrogen-inducible mRNA, indicating that the increase in
cytochrome oxidase
II mRNA is not a result of increasing the growth rate of the cells. The increase in
cytochrome oxidase
II mRNA was not caused by an increase in the number of copies of the
cytochrome oxidase
II gene. Estradiol therefore must induce in the mitochondria an increase in transcription or a decrease in degradation of
cytochrome oxidase
II mRNA.
...
PMID:Estrogen induces accumulation of the mitochondrial ribonucleic acid for subunit II of cytochrome oxidase in pituitary tumor cells. 283 64
