Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.9.3.1 (cytochrome oxidase)
 8,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Changes of vegetative reactions and cytochrome oxidase (CChO) activity in various brain structures were studied in rats during neurotization. One week neurotization led to an increase of arterial blood pressure, respiration rate, cardiac stroke volume and heart rate. In three weeks of neurotization there was a decrease of stroke volume accompanied by an increase of heart rate and some decrease or respiration rate leading to a reduction of oxygen consumption. Neurotization during one and especially three weeks elicited an enhancement of CChO activity in various brain areas, more pronounced in the cerebral cortex. A four week "rest" after neurotization during three weeks normalized the CChO activity. CChO activation during neurotization is supposed to be one of the mechanisms of adaptation to hypoxia accompanying neurosis.
 ...
PMID:[Changes in energy metabolism in several brain regions and vegetative responses of white rats during neurotization]. 608 71

It is established that emotional-painful stress and myocardium necrosis evoked in animals after the emotional-painful stress is accompanied by a disturbance in the creative metabolism and partial inhibition of cytochrome oxidase in cerebral hemispheres. A conclusion is made that the found changes may be one of the pathogenetic factors in formation of the neurosis-like states under stress and diseases originated from the effect of the emotional-psychic overstrain.
 ...
PMID:[Activity of Krebs cycle dehydrogenase and tissue respiration enzymes in cerebral hemispheres of rats under stress]. 627 89