Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.8.1.4 (diaphorase)
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Human Gene/Protein
diaphorase 1890
lipoamide dehydrogenase 883
NADH 594
NADPH 559
nitric oxide synthase 552
NAD 289
pyruvate dehydrogenase 201
Sep 181
FAD 169
pyruvate dehydrogenase complex 168
reductase 157
NAD+ 111
neuronal nitric oxide synthase 110
NADP 108
flavoprotein 104
Mol 104
glutathione reductase 102
lipoamide 96
polypeptide 94
oxidoreductase 94
acetylcholinesterase 84
lactate dehydrogenase 73
superoxide dismutase 69
ferredoxin 68
cytochrome c 61
NADP+ 56
alpha-ketoglutarate dehydrogenase 55
ATP 55
tyrosine hydroxylase 54
substance P 52
alkaline phosphatase 51
catalase 50
2-oxoglutarate dehydrogenase 50
glucose-6-phosphate dehydrogenase 49
peroxidase 48
choline acetyltransferase 47
dihydrolipoamide acetyltransferase 47
acid phosphatase 46
olfactory 43
dimeric 41
neuropeptide Y 41
somatostatin 40
endoplasmic reticulum 38
SDS 37
DT-diaphorase 37
GSH 35
thioredoxin reductase 35
cytochrome 34
axonal 34
microsomal 33
calbindin 33
ATPase 33
Pseudomonas 33
parvalbumin 32
protein X 32
calcitonin 31
ADP 31
Diaphorase 29
Gen 27
thioredoxin 26
malate dehydrogenase 26
SOD 26
FMN 26
citrate synthase 25
NADH diaphorase 25
NADH2 24
CA1 24
inducible nitric oxide synthase 24
NADH dehydrogenase 23
xanthine oxidase 23
isocitrate dehydrogenase 23
calretinin 22
glutamate dehydrogenase 22
esterase 21
Pyruvate dehydrogenase 21
insulin 21
glycine decarboxylase 21
spermatozoa 20
vasoactive intestinal peptide 20
membrane-bound 20
more...
Disease
cancer 46
SDS 37
GSH 35
ischemia 34
NAME 34
tumor 31
diabetes 30
Alzheimer's disease 24
Mycobacterium 24
tuberculosis 22
Huntington's disease 19
varices 18
Friedreich's ataxia 16
lactic acidosis 16
Parkinson's disease 14
carcinogenesis 12
hepatocellular carcinoma 12
PCC 11
pheochromocytoma 11
encephalopathy 10
carcinoma 10
Chagas 10
melanoma 9
Mycoplasma 9
hypertension 9
mole 9
heart failure 9
atherosclerosis 9
mole 9
schizophrenia 9
uterus 8
stroke 7
Leigh syndrome 7
cholera 7
depression 7
myopathy 7
cold 7
methemoglobinemia 7
SEM 6
Lissauer 6
DIA 6
breast cancer 6
dehydration 6
chronic granulomatous disease 6
malaria 6
epilepsy 5
neuroblastoma 5
epididymis 5
GCE 5
Lip 5
PDC 5
vagina 5
type 2 diabetes 5
pulmonary tuberculosis 5
LAD 5
obesity 5
asthma 4
cardiosclerosis 4
erectile dysfunction 4
fits 4
herpes simplex 4
ulcerative colitis 4
cognitive impairment 4
maple syrup urine disease 4
dysplasia 4
PDH deficiency 4
Dissociation 4
sleep disorders 4
cardiovascular disease 3
Steroids 3
CGD 3
Bardet-Biedl syndrome 3
genetic disorder 3
mastitis 3
glutaric aciduria 3
urethra 3
hepatitis 3
SCH 3
worms 3
leishmaniasis 3
more...
Symptom
pain 19
seizures 14
fatigue 8
starvation 7
ataxia 7
anesthesia 7
weakness 6
functional recovery 5
hypotonia 4
collapse 3
anorexia 3
hypothermia 3
constipation 2
vomiting 2
analgesia 2
memory loss 2
headache 2
respiratory distress 2
agitation 1
chronic constipation 1
Decreased activity 1
cyanosis 1
lethargy 1
abnormal gait 1
acute stress 1
anosmia 1
sleepiness 1
nausea 1
dystonia 1
thinning 1
hemoptysis 1
tachypnea 1
pallor 1
ophthalmoplegia 1
eds 1
abdominal pain 1
incoordination 1
ketonuria 1
dyspnea 1
arthralgia 1
stigma 1
orofacial pain 1
hepatomegaly 1
myalgia 1
tonic-clonic seizure 1
spasticity 1
urinary frequency 1
acidity 1
twitching 1
nasal congestion 1
Drug
NADH 625
FAD 169
lysine 30
ascorbate 23
citric acid 9
NBT 8
Gel 8
ROS 6
pyridoxal phosphate 6
Captopril 6
L-tyrosine 5
Vitamin K 5
Ethanol 5
caffeine 5
Glutathione 5
Cardiovasc 4
Nitric Oxide 4
THF 4
Kainic acid 3
DFP 3
Riboflavin 3
Flavin 3
Methylene blue 2
IL-2 2
Heme 2
Bifidobacterium 2
Nephron 2
vitamin E 2
niacin 2
Trifluoperazine 2
Sodium nitroprusside 2
Cibacron Blue 2
Dermatol 2
Apomorphine 2
Fraction 2
PTC 1
Photofrin II 1
EE2 1
MAP 1
Glycerol 1
Cocarboxylase 1
Taxol 1
Albumin 1
Vardenafil 1
Atabrine 1
CTX 1
DNase I 1
p75 1
Trypanothione 1
Gastro 1
lactose 1
Fragment 1
Ginseng 1
Clofibrate 1
GHRP 1
Phenprocoumon 1
HCG 1
Adriamycin 1
Fenbendazole 1
Sodium valproate 1
TAT 1
Ouabain 1
Clonidine 1
Leaf 1
AGG 1
TAC 1
Portal 1
Amiloride 1
Ethylenediamine 1
TiO2 1
Asn 1
PCP 1
Aminoguanidine 1
Amiloride 1
Vitamin E 1
MgSO4 1
Mutagen 1
Simvastatin 1
Paraffin 1
Enzyme
diaphorase 2754
diaphorase 1905
NQO1 1897
NADPH-diaphorase 1893
pyruvate dehydrogenase 295
NO synthase 245
pyruvate dehydrogenase 202
pyruvate dehydrogenase 201
alpha-ketoglutarate dehydrogenase 109
glutathione reductase 106
lactate dehydrogenase 88
succinate dehydrogenase 83
acetylcholinesterase 82
superoxide dismutase 75
NOS 70
peroxidase 60
glucose-6-phosphate dehydrogenase 60
ATPase 55
lipoate acetyltransferase 53
catalase 52
CPR 52
alkaline phosphatase 52
tyrosine hydroxylase 49
choline acetyltransferase 47
acid phosphatase 46
complex I 45
adrenodoxin reductase 41
thioredoxin reductase 37
cytochrome oxidase 36
malate dehydrogenase 36
pyruvate decarboxylase 31
branched-chain alpha-keto acid dehydrogenase 29
succinic dehydrogenase 29
isocitrate dehydrogenase 26
nitrate reductase 26
citrate synthase 26
hydrogenase 25
hydrogenase 25
trypsin 25
glycerol-3-phosphate dehydrogenase 24
glycerol-3-phosphate dehydrogenase 24
isocitrate dehydrogenase 23
mercuric reductase 23
NADH dehydrogenase 23
glycine decarboxylase 22
alcohol dehydrogenase 22
xanthine oxidase 21
glutathione peroxidase 21
nitrate reductase 21
nitrate reductase 21
nitrate reductase 21
nitrate reductase 21
nitrate reductase 21
dihydrolipoamide succinyltransferase 20
glutamate dehydrogenase 20
NADPH oxidase 20
glutamate dehydrogenase 19
glutamate dehydrogenase 19
NADH-cytochrome b5 reductase 18
enolase 17
transhydrogenase 17
NADPH oxidase 17
glucose-6-phosphatase 15
glutathione S-transferase 15
phosphorylase 14
trypanothione reductase 14
nitrite reductase 13
nitrite reductase 13
fumarase 13
nitrite reductase 13
aconitase 13
guanylate cyclase 13
ACE 12
beta-hydroxybutyrate dehydrogenase 12
hexokinase 12
glucose dehydrogenase 11
glyceraldehyde-3-phosphate dehydrogenase 11
pyruvate kinase 11
aldolase 10
ATP synthase 10
more...
Compound
nicotinamide 821
phosphate 815
NADH 622
NADPH 565
NADPH 563
nitric oxide 509
NAD 399
NAD 289
NADP 236
Dec 207
FAD 170
oxygen 166
arginine 130
glucose 112
sodium 103
DNA 101
dihydrolipoamide 96
hydrogen 89
calcium 68
2-oxoglutarate 63
water 57
pyridine 56
Clin 55
ATP 55
sulfate 52
CoA 52
cysteine 51
salt 50
iron 48
glutamate 46
acetate 45
His 42
H2O2 41
SDS 38
GSH 38
GSH 38
lysine 38
ethanol 37
nitrogen 35
ADP 33
Lipozyme 32
ADP 31
ADP 31
acetyl-CoA 30
copper 30
ammonium 29
tyrosine 28
FMN 28
alanine 27
CO2 27
methionine 26
nitrate 26
potassium 24
cyanide 24
naphthoquinone 23
naphthoquinone 23
naphthoquinone 23
naphthoquinone 23
naphthoquinone 23
naphthoquinone 23
naphthoquinone 23
serine 21
galactose 20
zinc 20
cGMP 19
cadmium 19
Ferredoxin 19
GSSG 19
alcohol dehydrogenase 19
glycerol 19
tryptophan 18
tryptophan 18
tryptophan 18
tryptophan 18
GABA 17
Gly 17
leucine 17
GABA 16
AMP 16
urea 16
more...