Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.8.1.4 (diaphorase)
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Human Gene/Protein
CGI-49 13.5
diaphorase 13.5
lipoamide dehydrogenase 13.3
Myosin light chain 3 12.5
solute carrier family 25 member 19 12.5
SH3 domain-binding glutamic acid-rich-like protein 3 12.5
complement Factor H-related protein 1 12.5
lipoamide 12.2
Diaphorase 12.1
DLDH 11.9
troponin I type 3 11.9
dihydrolipoamide acetyltransferase 11.7
70kD) 11.5
lipoic acid-containing protein 11.5
DRC2 11.2
dihydrolipoamide succinyltransferase 11.1
E3BP 11.0
pdhB 11.0
KGDHC 11.0
lat1 10.9
Glycine synthase 10.9
Nucleoside diphosphokinase 10.7
tubulin alpha-1 chain 10.7
neuronal tropomodulin 10.7
GIN1 10.7
NADH2 10.7
DIA1 10.6
neurofilament triplet L protein 10.5
NADH diaphorase 10.4
protein inhibitor of neuronal nitric oxide synthase 10.3
GluR4c 10.3
aflatoxin B1-aldehyde reductase 10.2
STARD6 10.2
DRS1 10.2
Lipoyltransferase 10.2
2-oxoglutarate dehydrogenase 10.2
pyruvate dehydrogenase complex 10.1
iron-sulfur protein 3 10.0
cvHSP 10.0
LIPT1 10.0
more...
Disease
Phosphoenolpyruvate carboxykinase deficiency 13.5
Lipoamide dehydrogenase deficiency 11.5
CHED 9.9
PDH deficiency 9.0
vitamin B deficiency 9.0
Lissauer 8.4
Bordetella infection 8.4
Persistent pulmonary hypertension 8.1
DTD 8.0
Reflux nephropathy 8.0
DIA 7.8
CGD 7.3
Ileum 7.3
ANM 7.3
erythrasma 7.2
stage I breast cancer 7.1
cardiosclerosis 6.9
Microangiopathy 6.9
CBS deficiency 6.8
Klebs 6.7
Chronic progressive external ophthalmoplegia 6.7
glutaric aciduria 6.6
favism 6.5
Friedreich's ataxia 6.5
hyperglycinemia 6.3
keratocyst 6.3
SGS 6.3
Retinal ischemia 6.3
lymphoblastoma 6.2
PDC 6.2
methemoglobinemia 6.2
alcoholic cardiomyopathy 6.1
PC deficiency 6.1
Spinal cord ischemia 6.1
Reye 6.1
Lip 6.1
SGS 5.9
Choroid 5.9
Choroid 5.9
PAPA 5.8
more...
Symptom
Decreased activity 4.4
ketonuria 4.4
orofacial pain 3.6
eds 3.4
urinary frequency 3.4
abnormal gait 3.4
nasal congestion 3.3
chronic constipation 3.2
tonic-clonic seizure 3.1
hypotonia 3.0
anosmia 2.9
incoordination 2.7
memory loss 2.7
twitching 2.5
ataxia 2.3
pallor 2.2
tachypnea 2.2
functional recovery 2.1
ophthalmoplegia 1.8
starvation 1.7
cyanosis 1.6
anorexia 1.3
acute stress 1.3
constipation 1.2
lethargy 1.0
seizures 1.0
hypothermia 1.0
hepatomegaly 1.0
hemoptysis 0.9
weakness 0.9
fatigue 0.8
spasticity 0.8
myalgia 0.8
arthralgia 0.7
dystonia 0.5
collapse 0.3
respiratory distress 0.2
thinning 0.0
agitation -0.1
sleepiness -0.1
more...
Drug
Cocarboxylase 10.7
FAD 8.5
NADH 8.4
Atabrine 7.6
Phenprocoumon 7.0
Flavin 6.7
Trypanothione 6.5
Fenbendazole 6.2
NBT 6.1
Vardenafil 6.1
Ethylenediamine 5.7
Kainic acid 5.7
Trifluoperazine 5.7
Cibacron Blue 5.6
Riboflavin 5.5
Photofrin II 5.5
Vitamin K 5.4
DFP 5.2
Sodium valproate 5.2
Captopril 4.9
pyridoxal phosphate 4.8
Aminoguanidine 4.8
L-tyrosine 4.6
Sodium nitroprusside 4.6
Clofibrate 4.4
GHRP 4.4
Apomorphine 4.2
Methylene blue 4.2
Nitric Oxide 4.2
AGG 3.9
Gastro 3.7
ascorbate 3.5
Glutathione 3.4
citric acid 3.4
Fraction 3.2
Amiloride 2.9
MgSO4 2.9
Heme 2.9
TAC 2.8
Ginseng 2.8
more...
Enzyme
4NQO reductase 13.5
malate-lactate transhydrogenase 13.5
diaphorase 13.5
asparagusate dehydrogenase 13.5
2-methylisocitrate dehydratase 12.5
NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase 12.5
NADPH-diaphorase 12.5
ferric leghemoglobin reductase 12.2
lipoate acetyltransferase 12.0
dihydrolipoyl transacylase 12.0
bis-gamma-glutamylcystine reductase 11.9
diaphorase 11.9
NQO1 11.8
dihydrolipoamide succinyltransferase 11.7
EC 1.1.1.108 11.5
p-benzoquinone reductase 11.2
2-oxoisovalerate dehydrogenase 11.2
12alpha-hydroxysteroid dehydrogenase 11.2
D-sorbitol dehydrogenase 10.6
4-N-trimethylaminobutyraldehyde dehydrogenase 10.3
bidirectional hydrogenase 10.2
2-oxoglutarate decarboxylase 10.2
mercuric reductase 10.1
NAD+ synthetase 10.0
diacetyl reductase 10.0
alpha-ketoglutarate dehydrogenase 9.9
4-hydroxyproline 2-epimerase 9.9
glycine reductase 9.9
coenzyme A disulfide reductase 9.8
branched-chain alpha-keto acid dehydrogenase 9.8
adrenodoxin reductase 9.7
PdxJ 9.5
4-hydroxybutyrate dehydrogenase 9.5
proteasome ATPase 9.5
BCKA 9.4
pyruvate dehydrogenase 9.4
pyruvate dehydrogenase 9.4
T-protein 9.3
pyruvate dehydrogenase 9.3
nicotinic acid hydroxylase 9.2
more...
Compound
Asparagusate 13.5
S-Methylisothiourea sulfate 13.5
Optochin hydrochloride 13.5
dihydrolipoamide 12.4
1-bromoheptane 12.1
5-Methoxyindole 11.5
CB 1954 11.4
spirost-5-en-3-ol 11.2
Trichloropropene oxide 10.9
2-Fluoroadenine 10.9
TNBT 10.6
EH2 10.3
Menadiol 10.2
Lipozyme 10.1
Dihydrolipoic acid 9.8
DEPA 9.6
S-(carboxymethyl)cysteine 9.3
S-(carboxymethyl)cysteine 9.3
Ferredoxin 9.3
p-Nitrobenzoic acid 9.2
nicotinamide 9.2
DEPA 9.2
NMOR 9.1
L-dopachrome 9.0
Fe(CN)3 8.9
Nitrofuran 8.9
1,3-Dinitrobenzene 8.7
2-nitroso-1-naphthol 8.6
Ferricyanide 8.5
FAD 8.5
Chorismate 8.4
2-methylcitric acid 8.4
NADH 8.4
2-hydroxybutanoic acid 8.3
2-oxoadipate 8.3
2,6-dichlorophenol 8.2
Chicago Sky Blue 6B 8.2
7-Ethoxyresorufin 8.2
Avertin 8.1
DCIP 8.1
more...